DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAT1A and Sam-S

DIOPT Version :10

Sequence 1:NP_000420.1 Gene:MAT1A / 4143 HGNCID:6903 Length:395 Species:Homo sapiens
Sequence 2:NP_524923.1 Gene:Sam-S / 48552 FlyBaseID:FBgn0005278 Length:408 Species:Drosophila melanogaster


Alignment Length:384 Identity:275/384 - (71%)
Similarity:341/384 - (88%) Gaps:1/384 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    11 HSLSEG-VFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSM 74
            :.:.:| .|:|||||||||||||:|||||||:||||||||||||||||||.||||:||||||||.
  Fly    21 YDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSK 85

Human    75 AMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMF 139
            |:||||:|||:|::|||||||:||||:||.|:|||:|||||:||..||::|.||||||||||:||
  Fly    86 AVVDYQKVVRETVQHIGYDDSSKGFDWKTLNLLVAIEQQSPNIANGVHINREEEDVGAGDQGIMF 150

Human   140 GYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIV 204
            ||||||||||||||::||||||.::|:||||.:..|.|||||||||.:|:.:.|:.:|.|:||||
  Fly   151 GYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIV 215

Human   205 ISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVD 269
            :|:||:|.|:||.:|..:.|:|::.|:||||:|.:|:.|:.|.|.||||||.||||:||||||||
  Fly   216 VSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVD 280

Human   270 TYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFT 334
            |||||||||||||||||:||||||||||||||||||||||||:|.|||||||||:||||||::|.
  Fly   281 TYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFD 345

Human   335 YGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKL 393
            ||||.|:::||||::.:|||||||.||:||:|::||||:|:.||||||:.|.||..:.|
  Fly   346 YGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPL 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAT1ANP_000420.1 PTZ00104 12..393 CDD:240268 274/381 (72%)
Flexible loop. /evidence=ECO:0000250|UniProtKB:P0A817 113..125 7/11 (64%)
Sam-SNP_524923.1 S-AdoMet_synt 30..399 CDD:350837 270/368 (73%)

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