DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcn3

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_038950796.1	Gene:	Clcn3 / 84360	RGDID:	621219	Length:	866	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	241/887 - (27%)
Similarity:	361/887 - (40%)	Gaps:	246/887 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK-----------------RRKQED 138
            |..:|:||:.:.. ||.....||...|.........|.:|::                 |.|.:|
  Rat    37 DFQTSEDDNLLDG-DTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKD 100

  Fly   139 KQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI--------SI 195
            ::|::.:..|     |:.|:|....::......|:.:.|.|:....|:.::|...        .|
  Rat   101 RERHRRINSK-----KKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGI 160

  Fly   196 CTNARIWL---------------YRDLTSQ--------------------PFVQYIAWVSLPVCL 225
            |.:| :|.               .||...|                    .::.||.|.   :..
  Rat   161 CLSA-LWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWA---LSF 221

  Fly   226 ILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFV 290
            ...:...|.:.||.:.||||||:||||.|..::.||...||:.|.|.|...:.||:.||||||.|
  Rat   222 AFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLV 286

  Fly   291 HIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRN 355
            |:|.....:.|.|...:.   .||::..|:|:||.|.||...|.||:||||||:|..:.||.::.
  Rat   287 HVACCCGNIFSYLFPKYS---TNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKT 348

  Fly   356 YWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYV 420
            .||.||||:..|.|.|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||.||.::
  Rat   349 LWRSFFAALVAAFVLRSINP-FGNSRLV--LFYVEYHT--PWYLFELFPFILLGVFGGLWGAFFI 408

  Fly   421 -----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSS----ISFPLGTGQFLAGELSTHE 476
                 |..||         :..||.:     ||....::|::    |:||....:     |:|.|
  Rat   409 RANIAWCRRR---------KSTKFGK-----YPVLEVIIVAAITAVIAFPNPYTR-----LNTSE 454

  Fly   477 QVTQLFS-----------------NFTWSRDDLTVEQAAVVTH---WMTSYTSVFGNLVIYTLFT 521
            .:.:||:                 |.:...||:....|.|..:   |......:|  .:|.|:||
  Rat   455 LIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIF--KIIMTVFT 517

  Fly   522 FVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPIMPGG 577
            |       .|.||||:|||...|||..||:||   |.:|      ..|......|.  ..|.||.
  Rat   518 F-------GIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGA--DCITPGL 573

  Fly   578 YAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKK 640
            ||:|||||..|.||. |||:.||:||:||.:.::||:|.||:.:..|. |..:..||::.|.:..
  Rat   574 YAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNG 638

  Fly   641 LPYL------------PDLL--PSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKTLR 690
            .|:|            .|::  ..|....::..:|.| |.|::.:.:..||             .
  Rat   639 YPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSY-------------N 690

  Fly   691 SLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQE------ 749
            ..|::.|.::..|:|...|.:|                         ..|:|..:||||
  Rat   691 GFPVIMSKESQRLVGFALRRDL-------------------------TIAIESARKKQEGVVGSS 730

  Fly   750 -VELKMRRPSRFEVLPA--PDILSLRQIANDEMLP-------PKKRAETMHGSLAPRK------- 797
             |......||    |||  |..|.||.|.  :|.|       |.:....:...|..|:
  Rat   731 RVCFAQHTPS----LPAESPRPLKLRSIL--DMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNG 789

  Fly   798 ---SILKKTNSF----NLKTYAQPMG---------HSPSITP 823
               .|:.|.|..    .||.:.:|:.         :.||..|
  Rat   790 IVLGIITKKNILEHLEQLKQHVEPLAPPWHYNKKRYPPSYGP 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	177/569 (31%)
		Voltage_CLC	227..615	CDD:279048	152/426 (36%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcn3	XP_038950796.1	ClC_3_like	136..642	CDD:239656	174/547 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	653..803	CDD:341367	39/193 (20%)
		CBS repeat	659..754	CDD:341367	29/136 (21%)
		CBS repeat	760..802	CDD:341367	6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810