Protein Alignment ClC-a and clcn1a

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_009292335.1
• Gene: clcn1a / 795133
• ZFINID: ZDB-GENE-060503-333
• Length: 1011
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 431/1179 - (36%)
• Similarity: 602/1179 - (51%)
• Gaps: 307/1179 - (26%)

  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQED----------------------------- 138
            |..|::||.|.:..|...:.||.:| ::|::||:..
Zfish    13 YQQTVLYGEYREHPGGSQRREATRL-LMERQRKKHGHHHHHGHYHHAHQGRSHSRSRSRHHSRPH 76

  Fly   139 --------KQRNKELLGKHSTRAKRVS--------SWIWRHTVARLGEDWVFLALLGIIMALLSF 187
                    ..|.:|..|..|:..||.|        :.:.:..|::|||||:||.||||.|||:|:
Zfish    77 LDLEIGSIHDRPEEEQGHTSSFKKRRSYSKCRDCVARVQKFLVSKLGEDWIFLVLLGITMALVSW 141

  Fly   188 IMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTIL 252
            .||...:....|..|.|.:|.....:||:.|||.|:.||||::.|.||:|||:||||||||||||
Zfish   142 SMDYASAKSLQAYKWFYGELRGNIPLQYLVWVSYPMVLILFASLFCHLVAPQAIGSGIPEMKTIL 206

  Fly   253 RGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRN 317
            |||.||||||.|..||||:||||.||||||:||||||||||||.|.:|||.::.|.|:|::....
Zfish   207 RGVVLKEYLTLKAFVAKVVGLTAGLGSGMPVGKEGPFVHIASICAAVLSKFMSFFSGVYQSPYGY 271

  Fly   318 SEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADT 382
            :::|...||||||.||..|:||||||||||:|||||||||||:|||...|.:||:|:|:.::|.|
Zfish   272 TDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGYFAATFSAFIFRVLSVFNKDAVT 336

  Fly   383 VRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLY 447
            :.|||.|||..:||||.|||..||:||:.||..||.:|:::|:.|||||....:.:||.|:|.::
Zfish   337 ITALFRTNFRMDFPFDLQELPAFAIIGISCGFLGAFFVYLNRQVVLFMRRPNILTRFLTKHRLVF 401

  Fly   448 PGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR---DDLT--VEQAAVVTHWMTSY 507
            |..:.|:|::::||.|.|||:||||...|.:..||.||||::   ..|.  :.::||   |....
Zfish   402 PAVVTLVVTTLTFPPGFGQFMAGELMPRECINSLFDNFTWTKIWGSPLPPGLGRSAV---WFHPD 463

  Fly   508 TSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSP 572
            .|:|..|:::.:..|.:|.:::|:|:|||.|:|||.:||.|||||||.||..||||:.:.|.|..
Zfish   464 VSIFVILILFLIMKFWMSAVSTTMPIPSGAFMPVFVLGAAFGRLVGEIMATLFPHGILFDGILYR 528

  Fly   573 IMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIIL 637
            |:||||||:||||.:|:||||||.|||.||:||||:|::|:|:||::||.||..||||:|||||.
Zfish   529 IIPGGYAVIGAAALTGAVTHTVSTAVICFELTGQISHILPMMVAVILANMVAQGLQPSLYDSIIQ 593

  Fly   638 IKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDN 700
            .|||||||:|.......|:|||||.|||.||::....:|   :|||.|  :.:|::.|||||.|:
Zfish   594 FKKLPYLPELGFGHISQYNIFVEDIMVRKVKFLCSQSTY---REVLHLLDSTSLKTFPLVDSKDS 655

  Fly   701 MILLGSVQRYELIKMIEKHIGREKRMEVAQK------------WQKEA--QERALEEEKKKQEVE 751
            ||||||::|.||:.:.:..:..|:|:.:..:            |:..|  .|   :||.:::.|:
Zfish   656 MILLGSIERSELLALCDWWLSAERRILIQGQSPQGQVPCAKISWESFAFVDE---DEEDEEENVD 717

  Fly   752 LKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMG 816
            .|              .:.:::..|..:.|||
Zfish   718 EK--------------TIPVQEERNGPVPPPK--------------------------------- 735

  Fly   817 HSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGV 881
                                                                       ||.|
Zfish   736 -----------------------------------------------------------PSEP-- 739

  Fly   882 SKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVA 946
                                                        |.|..|..:.||
Zfish   740 --------------------------------------------STNHTSPDKGPS--------- 751

  Fly   947 DVNRSPQTAKRCSKIRF--ANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKP 1009
                  |:.:|..:..|  ::|....|.|                                 |:|
Zfish   752 ------QSFRRLLRNLFSSSSERHTEGQP---------------------------------QEP 777

  Fly  1010 KSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGIN 1074
                .|......|:||..|.||..||.||:::.:  :.|||||||||||||:.|.|:|||::|::
Zfish   778 ----YPPPLTDTMTPEQIKAWEESEMDKPLEINQ--IRIDPSPFQLVERTSLHKTHTLFSLLGLS 836

  Fly  1075 HAYVTKIGRLVGVVGLKELRKAIEDINSNSFV---PPT---RD--EDADEKPAVEKP---LLSTN 1128
            |||||..|:|||||.||||:||||. ::.|.|   ||.   ||  .....||....|   .:||.
Zfish   837 HAYVTNTGKLVGVVALKELQKAIEG-STRSGVRLRPPLASFRDTLRKKASKPQASSPPSSPVSTT 900

  Fly  1129 SSDKAVDMTVTSMDSALSNS--------ENCSDIE--MEHIKH-TDKGTVSLTMPPQESKQSPSA 1182
            :....:...|.|...:.|:|        ||..::|  :|.:|. ...|..|.|.....|..|...
Zfish   901 APSSPLSPPVISHSHSHSHSSSPPAPVEENKKEMEVWIEGVKRDVIVGKSSSTTTGSSSSSSRGN 965

  Fly  1183 DKSNTENGN 1191
            ..|::|.|:
Zfish   966 GSSDSEAGS 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	268/479 (56%)
		CBS_pair_SF	659..>718	CDD:449531	29/60 (48%)
		CBS repeat	664..715	CDD:341358	25/52 (48%)
		CBS_pair_SF	<1032..1096	CDD:449531	38/63 (60%)
		CBS repeat	1053..1095	CDD:341358	29/41 (71%)
clcn1a	XP_009292335.1	ClC_1_like	125..602	CDD:239655	268/479 (56%)
		CBS_pair_voltage-gated_CLC_euk_bac	615..858	CDD:341367	103/454 (23%)
		CBS repeat	620..778	CDD:341367	54/367 (15%)
		CBS repeat	815..857	CDD:341367	29/41 (71%)