Protein Alignment ClC-a and Clcnkb

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_775126.1
• Gene: Clcnkb / 79430
• RGDID: 628639
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 257/673 - (38%)
• Similarity: 393/673 - (58%)
• Gaps: 58/673 - (8%)

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.|:||||.||..||::|||:|:.|:..|.....|..||||::.....::|::|...||
  Rat    38 WL-KERLFRVGEDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREIGDGHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.||||||:||||.||.|::||..|...|||:||:.||  ||.:.|||.
  Rat   102 ALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCTLATGSTIFLGKL 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.::|..|.::.|...|..||:::..|:|||..||||...||||:.||||||||.:::|
  Rat   167 GPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.:||||||||.|||.:|.||||:....:|:.:::.|:|..:.|||..|:|.|..:|.:||:..
  Rat   232 SVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILS 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ..|.:..|..:.|::||...:|.|..::.||....|::::||::|.|.|:|:|..||..|.:..|
  Rat   297 CGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASITYPPGVGRFMASRLSMSEYLETL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |..:.::           :...|.....:|||.||.:.:..|.:.|:|:|||:|:
  Rat   362 FDNNSWA---LMTKNSSPPWSAEPDPQNLWLEWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|..||..|||.||.:::.||.|:..||::||||||.||:.|||||||:||||:|.|::.
  Rat   424 GYFLPIFVYGAAIGRLFGEVLSLAFPEGIVAGGKVSPIMPGAYALAGAAAFSGAVTHTLSTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFM-- 663
            ||::|||.|.:||::|||.|||:....|||.||..|::|||||||.:.....|.:.:.|..||
  Rat   489 FEVSGQIVHALPVLMAVLAANAICQSYQPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFMNC 553

  Fly   664 -----VRDVKYIWHGISYQKLKEVLK--LNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIG 721
                 .:|:          .|:||:|  ::..:...|||::.::.:|:|.|:|..|::.:...
  Rat   554 TLTTLAKDM----------PLEEVIKVVISTDVTQYPLVETTESQVLVGIVKRTHLVQSLHTD-- 606

  Fly   722 REKRMEVAQKW---QKEAQERALEEEKKKQEVELKM-RRPSRFEVLPAPDILSL---------RQ 773
                   :..|   |:...:..|......|.|.|:: ...|..|.....::|:|         |.
  Rat   607 -------SASWAPGQQPCLQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRA 664

  Fly   774 IANDEMLPPKKRAETMHGSLAPR 796
            :.:...:..||...|:....||:
  Rat   665 VGSVSWVELKKAISTLTNPPAPK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	219/487 (45%)
		Voltage_CLC	227..615	CDD:279048	179/400 (45%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcnkb	NP_775126.1	ClC_1_like	49..533	CDD:239655	218/486 (45%)
		Voltage_CLC	106..513	CDD:279048	185/409 (45%)
		CBS	547..604	CDD:278968	16/66 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810