Protein Alignment ClC-a and Clcnka

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_445779.2
• Gene: Clcnka / 79425
• RGDID: 68435
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 246/619 - (39%)
• Similarity: 374/619 - (60%)
• Gaps: 60/619 - (9%)

  Fly   154 KRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAW 218
            :|...|: :..:.|:||||.||..||::|||:|:.|:..|.....|..||||::.....::|::|
  Rat    33 RRGLEWL-KERLFRVGEDWHFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSW 96

  Fly   219 VSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGM 281
            ...||.|:.||:||...|:|.|.|||:||:||:|.||.|::||..|...|||:||:.||  ||.:
  Rat    97 TVYPVALLSFSSGFSQSISPFSGGSGLPELKTMLSGVVLEDYLDIKNFGAKVVGLSCTLATGSTI 161

  Fly   282 PLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEV 346
            .|||.|||||::.:::..|.::.....|..||:::..|||:||.||||...||||..||||||||
  Rat   162 FLGKVGPFVHLSVMISAYLGRVRAKTIGETENKAKEIEMLSAAAAVGVATVFAAPFSGVLFSIEV 226

  Fly   347 TTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLV 411
            .:::|:|.|||||||||.|||.:||||.|:....:|:.:::.|.|..:.|||..|:|.|..:|.:
  Rat   227 MSSHFSVWNYWRGFFAATCGAFMFRLLGVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFI 291

  Fly   412 CGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHE 476
            ||:...:|::..|.::.|:::|:..::.|..::..|...:||:::||::|.|.|:|:|..||..|
  Rat   292 CGVLSCAYLFCQRTFLCFIKTNRYTSRLLATSKPSYAALVALVLASITYPPGVGRFMASRLSMAE 356

  Fly   477 QVTQLFSNFTWSRDDLTVEQAAVVT------------------HWMTSYTSVFGNLVIYTLFTFV 523
            .:..||.|.:|          |::|                  .|.....::||.|..:.:..|.
  Rat   357 HLHSLFDNNSW----------ALMTRNSSPPWPAEPDPQNLWLEWCHPRFTIFGTLAFFLVMKFW 411

  Fly   524 VSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSG 588
            :.|:|:|||:|:|.|:|:|.|||..|||:||.::|.||.|:..|..::||||||||:.|||||||
  Rat   412 MLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGREVNPIMPGGYALAGAAAFSG 476

  Fly   589 SVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSG 653
            :||||:|.|::.||:||||.|.:||::|||.|||::...|||.||..|:.|||||||.:.....|
  Rat   477 AVTHTISTALLAFELTGQIVHALPVLMAVLAANAISQNCQPSFYDGTIMAKKLPYLPWIRGRQIG 541

  Fly   654 MYSIFVEDFM-------VRDVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQR 709
            .|.:.||.||       .:|.          .|:||:|:  :..:...|||::.::..|:|.|:|
  Rat   542 SYPVTVEHFMNCNLTTLAKDT----------PLEEVVKVVTSTEVSQYPLVETRESQTLVGIVER 596

  Fly   710 YELIKMIEKHIGREKRMEVAQKWQKEAQERALEE 743
            ..|::.::..         ...| ...|||.|::
  Rat   597 THLVQALQTQ---------PASW-APGQERFLQD 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	216/494 (44%)
		Voltage_CLC	227..615	CDD:279048	176/407 (43%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcnka	NP_445779.2	ClC_1_like	49..533	CDD:239655	215/493 (44%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	22/95 (23%)
		CBS repeat	552..627	CDD:341367	18/89 (20%)
		CBS repeat	633..675	CDD:341367

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950