Protein Alignment ClC-a and clcn4

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001070786.1
• Gene: clcn4 / 768175
• ZFINID: ZDB-GENE-061013-353
• Length: 768
• Species: Danio rerio
• Alignment Length: 746
• Identity: 207/746 - (27%)
• Similarity: 313/746 - (41%)
• Gaps: 187/746 - (25%)

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI---- 193
            |.|.:|..|::::..|     .:.|.|.:..::......|:.:.|:|::...|:.::|..:
Zfish    46 REKSKDTDRHRKITSK-----SKESIWEFIKSLLDAWSGWLVMLLIGLLSGTLAGVIDLAVDWMT 105

  Fly   194 ----SICTNARIW-------------LYRDLTSQP----------------------FVQYIAWV 219
                .:|.:| .|             .:.|....|                      :..|:.|.
Zfish   106 DLKEGVCLSA-FWYSHEQCCWTSNETTFADRDKCPQWQKWAELVTGYTEGAGVYVLNYFLYVLWA 169

  Fly   220 SLPVCLILFS---AGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGM 281
                  :.||   ...|.:.||.:.||||||:||||.|..::.||...||:.|.:.|...:.||:
Zfish   170 ------LFFSFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLAVSSGL 228

  Fly   282 PLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEV 346
            .||||||.||:|.....|...|.:.:.   :||.:..|:|:||.|.||...|.||:||||||:|.
Zfish   229 SLGKEGPLVHVACCCGNLFCSLFSKYS---KNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEE 290

  Fly   347 TTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLV 411
            .:.||.::..||.||||:..|...|.:..:..|.   ..||...:.|  |:...||..|.|:|:.
Zfish   291 VSYYFPLKTLWRSFFAALVAAFTLRSINPFGNNR---LVLFYVEYHT--PWYMAELVPFILLGVF 350

  Fly   412 CGLGGASYV-----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQF 467
            .||.|..::     |..|      |...|:.|        ||....|.|:.|    :||....:
Zfish   351 GGLWGTLFIRCNIAWCRR------RKTTRLGK--------YPVLEVLAVTGITAVLAFPNPYTR- 400

  Fly   468 LAGELSTHEQVTQLFS-----------------NFTWSRDDLTVEQAAVVTH---WMTSYTSVFG 512
                .||.|.:::||:                 |.|...||:....|....:   |..:....|
Zfish   401 ----RSTSELISELFNDCGALESSQLCDYINSPNMTRPVDDIPDRPAGPGVYSALWQLTLALAF- 460

  Fly   513 NLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGG 568
             .:|.|:|||.:.|       |||:|||...:||..||:||   |.||      :.|.:..|.|.
Zfish   461 -KIIITIFTFGMKI-------PSGLFIPSMAVGAIAGRIVGIAVEQMAYHHHDWIIFKNWCRPGA 517

  Fly   569 RLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSI 631
              ..:.||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| |..:..|
Zfish   518 --DCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGI 580

  Fly   632 YDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDV----------KYIWHGISYQKLKEVLKLN 686
            |::.|.:...|||..         ..|....:..||          ..:....|..:..|.|..:
Zfish   581 YEAHIQLNGYPYLDQ---------DEFTHRTLATDVMRPRRSEPPLSVLTQDSSTLEEAEALITH 636

  Fly   687 KTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQK----WQKEAQERALEEEKKK 747
            ......|:|.|.::..|:|.|||.:||..|:.  .|:|:..|...    :.::|.:
Zfish   637 TDYNGFPVVVSRESERLIGFVQRRDLILAIKN--ARQKQDGVVSNSVVYFTEDAPQ--------- 690

  Fly   748 QEVELKMRRPSRFEVLPAPDI--LSLRQIAN 776
                           |||.:.  |.||:|.|
Zfish   691 ---------------LPASNTQPLKLRRILN 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	171/560 (31%)
		CBS_pair_SF	659..>718	CDD:449531	16/68 (24%)
		CBS repeat	664..715	CDD:341358	15/60 (25%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clcn4	NP_001070786.1	ClC_3_like	87..593	CDD:239656	167/550 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	603..753	CDD:341367	28/130 (22%)
		CBS repeat	609..704	CDD:341367	24/120 (20%)
		CBS repeat	710..752	CDD:341367