DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and clcn4

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001070786.1	Gene:	clcn4 / 768175	ZFINID:	ZDB-GENE-061013-353	Length:	768	Species:	Danio rerio

Alignment Length:	746	Identity:	207/746 - (27%)
Similarity:	313/746 - (41%)	Gaps:	187/746 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI---- 193
            |.|.:|..|::::..|     .:.|.|.:..::......|:.:.|:|::...|:.::|..:
Zfish    46 REKSKDTDRHRKITSK-----SKESIWEFIKSLLDAWSGWLVMLLIGLLSGTLAGVIDLAVDWMT 105

  Fly   194 ----SICTNARIW-------------LYRDLTSQP----------------------FVQYIAWV 219
                .:|.:| .|             .:.|....|                      :..|:.|.
Zfish   106 DLKEGVCLSA-FWYSHEQCCWTSNETTFADRDKCPQWQKWAELVTGYTEGAGVYVLNYFLYVLWA 169

  Fly   220 SLPVCLILFS---AGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGM 281
                  :.||   ...|.:.||.:.||||||:||||.|..::.||...||:.|.:.|...:.||:
Zfish   170 ------LFFSFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLAVSSGL 228

  Fly   282 PLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEV 346
            .||||||.||:|.....|...|.:.:.   :||.:..|:|:||.|.||...|.||:||||||:|.
Zfish   229 SLGKEGPLVHVACCCGNLFCSLFSKYS---KNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEE 290

  Fly   347 TTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLV 411
            .:.||.::..||.||||:..|...|.:..:..|.   ..||...:.|  |:...||..|.|:|:.
Zfish   291 VSYYFPLKTLWRSFFAALVAAFTLRSINPFGNNR---LVLFYVEYHT--PWYMAELVPFILLGVF 350

  Fly   412 CGLGGASYV-----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQF 467
            .||.|..::     |..|      |...|:.|        ||....|.|:.|    :||....:
Zfish   351 GGLWGTLFIRCNIAWCRR------RKTTRLGK--------YPVLEVLAVTGITAVLAFPNPYTR- 400

  Fly   468 LAGELSTHEQVTQLFS-----------------NFTWSRDDLTVEQAAVVTH---WMTSYTSVFG 512
                .||.|.:::||:                 |.|...||:....|....:   |..:....|
Zfish   401 ----RSTSELISELFNDCGALESSQLCDYINSPNMTRPVDDIPDRPAGPGVYSALWQLTLALAF- 460

  Fly   513 NLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGG 568
             .:|.|:|||.:.|       |||:|||...:||..||:||   |.||      :.|.:..|.|.
Zfish   461 -KIIITIFTFGMKI-------PSGLFIPSMAVGAIAGRIVGIAVEQMAYHHHDWIIFKNWCRPGA 517

  Fly   569 RLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSI 631
              ..:.||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| |..:..|
Zfish   518 --DCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGI 580

  Fly   632 YDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDV----------KYIWHGISYQKLKEVLKLN 686
            |::.|.:...|||..         ..|....:..||          ..:....|..:..|.|..:
Zfish   581 YEAHIQLNGYPYLDQ---------DEFTHRTLATDVMRPRRSEPPLSVLTQDSSTLEEAEALITH 636

  Fly   687 KTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQK----WQKEAQERALEEEKKK 747
            ......|:|.|.::..|:|.|||.:||..|:.  .|:|:..|...    :.::|.:
Zfish   637 TDYNGFPVVVSRESERLIGFVQRRDLILAIKN--ARQKQDGVVSNSVVYFTEDAPQ--------- 690

  Fly   748 QEVELKMRRPSRFEVLPAPDI--LSLRQIAN 776
                           |||.:.  |.||:|.|
Zfish   691 ---------------LPASNTQPLKLRRILN 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	171/560 (31%)
		Voltage_CLC	227..615	CDD:279048	148/429 (34%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
clcn4	NP_001070786.1	ClC_3_like	87..593	CDD:239656	167/550 (30%)
		Voltage_CLC	171..573	CDD:279048	151/439 (34%)
		CBS	606..751	CDD:223591	28/127 (22%)
		CBS_pair_EriC_assoc_euk_bac	615..753	CDD:239964	26/118 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810