DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and clcn5

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001039210.1	Gene:	clcn5 / 734069	XenbaseID:	XB-GENE-5957241	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	817	Identity:	226/817 - (27%)
Similarity:	356/817 - (43%)	Gaps:	226/817 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SDSSDDD--------------DPIGYIDTLMYGRYTKDLGEFAKDEARKLKILE----------- 131
            |.:||:|              |.:..||..|.|.:....|......::.:..|:
Frog    16 SSTSDEDMVEINEATLDFTMTDDVPPIDRDMAGGFVSYNGNGLHGPSKVMDFLDVPGVGTYEDFN 80

  Fly   132 ----KRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD-- 190
                .|.|..|:.|::|:|.|     .:.|:|....:::.....|:.:.|:|:....|:.::|
Frog    81 TIDWVREKSRDRDRHREILSK-----SKESTWALLRSISDAFSGWMLMLLIGLTAGSLAGLIDIS 140

  Fly   191 --------KGISI------------------------CTNARIW----LYRDLTSQPFV----QY 215
                    :||.:                        |...|.|    |.|...:.|::    .|
Frog   141 SHWMTDLKEGICLPWFWFNHEQCCWQSNNVTFEDRNNCPEWRSWSQLVLGRSEGAFPYILNYFMY 205

  Fly   216 IAWVSLPVCLILFSAGFVHLI---APQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL 277
            :.|.      :|||...|.|:   ||.:.||||||:||||.|..::.||...||:.|.:.|...:
Frog   206 VLWA------LLFSLLAVLLVRNFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKTMTLVLAV 264

  Fly   278 GSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLF 342
            .||:.||||||.:|:|.....:|..|.|.::   :||::..|:|:||.|.||...|.||:|||||
Frog   265 SSGLSLGKEGPLIHVACCCGNILCHLFTKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLF 326

  Fly   343 SIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFAL 407
            |:|..:.||.::..||.||||:..|...|.:.. |.|:..|  ||...|  ..|:...||..|.|
Frog   327 SLEEVSYYFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEF--HAPWHLLELIPFIL 386

  Fly   408 IGLVCGLGGASYV-----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI----SFPLG 463
            :|:..||.||.::     |..||            |..:..|  ||....|:|::|    :||..
Frog   387 LGIFGGLWGAFFIRGNIAWCQRR------------KTTKLGR--YPVAEVLVVTAITAVLAFPND 437

  Fly   464 TGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSV-FGNLV-------IYT-- 518
            ..:     :|:.|.:::||       :|..:..::.:..::..|.:. .|||.       :||
Frog   438 YTR-----MSSSEMISELF-------NDCGLLDSSKLCDYVNDYNNTKGGNLPDRAAGNGVYTAM 490

  Fly   519 -------LFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFM-AVTFPH--GVRYGGRLSP- 572
                   :|..|::|....:.||||:|||...:||..|||:|..| .::|.|  .:.:.|..:.
Frog   491 WQLSLALIFKAVITIFTFGMKVPSGLFIPSMAVGAIMGRLLGVAMEQLSFYHHDWLIFRGWCNQG 555

  Fly   573 ---IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIY 632
               |.||.||:|||||..|..|. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:.|||
Frog   556 ADCITPGLYAMVGAAACLGGATRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGRESIY 620

  Fly   633 DSIILIKKLPYLP------------DLL--PSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEV 682
            |:.|.:...|:|.            |::  ..:..:.::..:|.| |.|::.|
Frog   621 DAHIHLNGYPFLEAKEEFSHKTLAMDVMRPRRNDPILTVITQDSMTVEDIEAI------------ 673

  Fly   683 LKLNKTLRS-LPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKK 746
              :|:|..| .|:|.|.::..|:|.|.|.:||                         .::|..:|
Frog   674 --INETTYSGFPIVISRESQRLVGFVLRRDLI-------------------------ISVESARK 711

  Fly   747 KQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPK 783
            |||                 .|:|..||...|..||:
Frog   712 KQE-----------------GIVSTSQIYFTEHTPPQ 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	176/566 (31%)
		Voltage_CLC	227..615	CDD:279048	148/424 (35%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
clcn5	NP_001039210.1	ClC_3_like	127..632	CDD:239656	173/544 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	643..793	CDD:341367	30/145 (21%)
		CBS repeat	649..744	CDD:341367	29/139 (21%)
		CBS repeat	750..792	CDD:341367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910