DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcn4

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_006256890.1	Gene:	Clcn4 / 60586	RGDID:	708381	Length:	774	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	215/742 - (28%)
Similarity:	324/742 - (43%)	Gaps:	178/742 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI---- 193
            |.|..|..|::::..|     .:.|.|.:..::......||.:.|:|::...|:.::|..:
  Rat    51 REKSRDTDRHRKITSK-----SKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMT 110

  Fly   194 ----SICTNARIWLYRD--------------------------LTSQP---------FVQYIAWV 219
                .:|.:| .|...:                          |.||.         ::.||.|.
  Rat   111 DLKEGVCLSA-FWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWA 174

  Fly   220 SLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLG 284
            .|   ....:...|.:.||.:.||||||:||||.|..::.||...||:.|.:.|...:.||:.||
  Rat   175 LL---FAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLG 236

  Fly   285 KEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTT 349
            ||||.||:|.......|.|.:.:.   :||.:..|:|:||.|.||...|.||:||||||:|..:.
  Rat   237 KEGPLVHVACCCGNFFSSLFSKYS---KNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSY 298

  Fly   350 YFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGL 414
            ||.::..||.||||:..|...|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||
  Rat   299 YFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEYHT--PWYMAELFPFILLGVFGGL 358

  Fly   415 GGASY-----VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLG-----TGQFLA 469
            .|..:     .|..|      |...|:.|        ||....::|::|:..:.     |.|
  Rat   359 WGTVFTRCNIAWCRR------RKTTRLGK--------YPVLEVIVVTAITAIIAYPNPYTRQ--- 406

  Fly   470 GELSTHEQVTQLFS-----------------NFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
               ||.|.:::||:                 |.|...||:....|.|..     ||::: .|.:.
  Rat   407 ---STSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGV-----YTAMW-QLALA 462

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPI 573
            .:|..|::|....:.:|||:|||...:||..||:||   |.:|      :.|.:..|.|.  ..:
  Rat   463 LIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGA--DCV 525

  Fly   574 MPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSII 636
            .||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| |..:..||::.|
  Rat   526 TPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHI 590

  Fly   637 LIKKLPYL------------PDLLPSSSG--MYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLN 686
            .:...|:|            .|::....|  ..|:..:|.| |.||:.:        :||.
  Rat   591 HLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETL--------IKET---- 643

  Fly   687 KTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVE 751
             .....|:|.|.|:..|:|..||.|||..|                 |.|::|  :|......:.
  Rat   644 -DYNGFPVVVSRDSERLIGFAQRRELILAI-----------------KNARQR--QEGIVSNSIM 688

  Fly   752 LKMRRPSRFEVLPA--PDILSLRQIAN 776
            .....|..   |||  |..|.||:|.|
  Rat   689 YFTEEPPE---LPANSPHPLKLRRILN 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	172/567 (30%)
		Voltage_CLC	227..615	CDD:279048	146/424 (34%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcn4	XP_006256890.1	ClC_3_like	92..598	CDD:239656	168/545 (31%)
		Voltage_CLC	176..578	CDD:279048	150/440 (34%)
		CBS	612..757	CDD:223591	36/136 (26%)
		CBS_pair_EriC_assoc_euk_bac	621..759	CDD:239964	34/127 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810