Protein Alignment ClC-a and clcn1b

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_021322563.1
• Gene: clcn1b / 567478
• ZFINID: ZDB-GENE-100921-11
• Length: 956
• Species: Danio rerio
• Alignment Length: 1145
• Identity: 411/1145 - (35%)
• Similarity: 594/1145 - (51%)
• Gaps: 263/1145 - (22%)

  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQR-------------------------N 142
            |..||:||.|.:.||..::.||.:|...::.::..|..:                         :
Zfish    13 YQQTLLYGEYREQLGNISRREATRLLTEKQWKRHADNSKATRRGHGRAHHASLDVGPLTPGLSPS 77

  Fly   143 KELLGKHS-TRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRD 206
            ..|:..|. .:.:...:.:.|:.|.:|||||:||.|||:.|||:|:.||...:....|..|:|.:
Zfish    78 SSLIKSHPYFKCQDCLARVQRYIVTKLGEDWIFLVLLGLTMALVSWSMDYASAKSIQAYKWMYGE 142

  Fly   207 LTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVI 271
            |.....:||:||||.|:.|::|::.|.||:|||:|||||||:|||||||.||||||.|..|||||
Zfish   143 LKGNVALQYLAWVSYPIILVVFASLFCHLVAPQAIGSGIPELKTILRGVVLKEYLTLKAFVAKVI 207

  Fly   272 GLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAP 336
            ||||.||||||:||||||||||||.|.:||::::.|.|:|||....:::|...||||||.||..|
Zfish   208 GLTAGLGSGMPIGKEGPFVHIASICAAVLSRVMSIFTGVYENPYGYTDILTVGCAVGVGCCFGTP 272

  Fly   337 VGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQE 401
            :||||||||||:|||||||||||:|||...|.:||:|:||.:::.|:.|||.|||..:||||.||
Zfish   273 LGGVLFSIEVTSTYFAVRNYWRGYFAATFSAFIFRVLSVWNKDSVTITALFRTNFRMDFPFDLQE 337

  Fly   402 LFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQ 466
            |..||:||:.||..||.:|:::|:.||.||....:.:||.|:|.:|||.:.|:::|.:||.|.||
Zfish   338 LPAFAIIGISCGFLGAFFVYLNRQVVLIMRRPTALTRFLTKHRLIYPGAVTLIIASFTFPPGFGQ 402

  Fly   467 FLAGELSTHEQVTQLFSNFTWSR-------DDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVV 524
            |:||||...|.:..||.|:||::       ..|....|     |:....|||..|:::.:..|.:
Zfish   403 FMAGELMPRECINSLFDNYTWTKIWGSPVPPGLGRSAA-----WLHPQVSVFVILLLFFVMKFWM 462

  Fly   525 SIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGS 589
            |.:::|:|||||.|:|||.:||.|||||||.||..||:|:.:.|.:..|:||||||:||||.:|:
Zfish   463 SAVSTTMPVPSGAFMPVFILGAAFGRLVGEIMATLFPNGILFDGIVYQILPGGYAVIGAAAMTGA 527

  Fly   590 VTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGM 654
            ||||||.|||.||:||||:|::|:|:||::||.||..||||:|||||.:|||||||:|.......
Zfish   528 VTHTVSTAVICFELTGQISHILPMMVAVILANMVAQGLQPSLYDSIIQVKKLPYLPELGIGHISK 592

  Fly   655 YSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKH 719
            |:|||||.||:.:|::....:|::||::|: :.:|:::||:||.|.||||||::|.||
Zfish   593 YNIFVEDIMVKKIKFLSPQSTYRELKDLLE-STSLKTIPLIDSKDTMILLGSIERCEL------- 649

  Fly   720 IGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKK 784
                   :.|..|...|:.|..    .:.|....:.....:|.....|    .::..:......:
Zfish   650 -------QAALDWWLSAERRVY----NRGEGMASLVSEGSWESFVFVD----EEVGEENRDKGNR 699

  Fly   785 RAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFR-IRSAFEAIFKKSTT 848
            .:|..:|                      |:|.|.:....|..|.:...: :|..|:.:|..|::
Zfish   700 VSEECNG----------------------PVGSSKTTDISTNHTTSGALKSMRRTFQRLFSSSSS 742

  Fly   849 LQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNK 913
              ..|..||...||||..      .::|:.|.|
Zfish   743 --SGQTKPEFTKLSPAGG------VKSPAAPPV-------------------------------- 767

  Fly   914 MPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKC 978
                                                                             
Zfish   768 ----------------------------------------------------------------- 767

  Fly   979 KIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQK 1043
                                                    |.:|:||:.|.||.:|:.|||.:.:
Zfish   768 ----------------------------------------VDNMTPEEIKAWEEKELDKPIGIDQ 792

  Fly  1044 ANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFV-- 1106
              :.:||||||||||||:.|.|:|||::|::|||||.||:|||||.||||:||||. ::.|.|
Zfish   793 --IRVDPSPFQLVERTSLHKTHTLFSLLGLSHAYVTSIGKLVGVVALKELQKAIEG-STRSGVRL 854

  Fly  1107 -PPT---RDEDADEKPAVEKPLLSTN---------------SSDKAVDMTVTSMDSALSNSENCS 1152
             ||.   ||.....|.....|.:.::               |.:::....:.:::....:|.|..
Zfish   855 RPPLASFRDARRKTKKPSHSPSIPSSPTQDIELWSEAVRRESKEESAGSCIQTVEKECESSRNIV 919

  Fly  1153 DIEMEHIKHTDKGTVSLTMPPQESKQSP----SADKSNTE 1188
            ....|.:..      |.|:|.......|    .|:|...|
Zfish   920 STSEEQLPS------SSTVPLSSLHSVPGGEGDAEKERDE 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	266/481 (55%)
		Voltage_CLC	227..615	CDD:279048	219/394 (56%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	45/95 (47%)
clcn1b	XP_021322563.1	ClC_1_like	107..584	CDD:239655	266/481 (55%)
		CBS_pair_EriC_assoc_euk_bac	<795..843	CDD:239964	34/47 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	502	1.000	Domainoid score	I334
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	781	1.000	Inparanoid score	I505
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	1	1.000	-	-		FOG0002718
OrthoInspector	1	1.000	-	-		otm24854
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4171
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010