DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcnkb

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_062675.2	Gene:	Clcnkb / 56365	MGIID:	1930643	Length:	687	Species:	Mus musculus

Alignment Length:	673	Identity:	255/673 - (37%)
Similarity:	394/673 - (58%)	Gaps:	58/673 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.|:||||.||..||::|||:|:.|:..|.....|..||||::.....::|::|...||
Mouse    38 WL-KERLFRVGEDWYFLVALGVLMALISYAMNFTIGRVVRAHKWLYREIGDGHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.||||||:||||.||.|::||..|...|||:||:.||  ||.:.|||.
Mouse   102 ALLSFSSGFSQSITPSSGGSGIPEVKTILTGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKL 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.::|..|.::.|...|..|::::..|:|||..||||...||||:.||||||||.:::|
Mouse   167 GPFVHLSVMIAAYLGRVRTKTVGEPESKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.:||||||||.|||.:|.||||:....:|:.:::.|:|..:.|||..|:|.|..:|.:||:..
Mouse   232 SVWDYWRGFFAATCGAFMFHLLAVFNNEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILS 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ..|.:..|.::.|:::|...:|.|..::.||....|::::||::|.|.|.|:|..||..|.:..|
Mouse   297 CGYNYSQRTFLFFLKANGFTSKLLATSKPLYSALAAVVLASITYPPGVGHFMASRLSMSEHLETL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |..:.::           :...|.....:|||.||.:.:..|.:.|:|:|||:|:
Mouse   362 FDNNSWA---LMTKNSSPPWAAEPDPQKLWLEWCHPQLTVFGTLVFFLVMKFWMLILATTIPIPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|..||..|||.||.::|.||.|:..|||::|||||.||:.|||||||:||||:|.|::.
Mouse   424 GYFLPIFIYGAVIGRLFGEVLSVAFPEGIVAGGRVNPIMPGAYALAGAAAFSGAVTHTLSTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFM-- 663
            ||:|||:.|.:||::|||.|||::...|||.||..|::|||||||.:.....|.:|:.|..||
Mouse   489 FEVTGQLVHALPVLMAVLAANAISQSFQPSFYDGTIIVKKLPYLPWIRGRQIGSHSVTVGHFMNC 553

  Fly   664 -----VRDVKYIWHGISYQKLKEVLK--LNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIG 721
                 .:|:          .|::|::  ::..:...|||::.::..|:|.|:|..|::.::..
Mouse   554 ALTTLAKDM----------PLEQVIQVVISTDVTQYPLVETTESQTLVGVVKRTHLVQALQTE-- 606

  Fly   722 REKRMEVAQKW---QKEAQERALEEEKKKQEVELKMR-RPSRFEVLPAPDILSL---------RQ 773
                   ...|   |:...:..|......|.|.|::. ..|..|.....::|:|         |.
Mouse   607 -------PASWAPGQQPCLQDILANGCPTQPVTLQLSLETSLHETHNLFELLNLQTLFVTSRGRA 664

  Fly   774 IANDEMLPPKKRAETMHGSLAPR 796
            :.:...:..||...|:....||:
Mouse   665 VGSVSWVELKKAISTLTNPPAPK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	218/487 (45%)
		Voltage_CLC	227..615	CDD:279048	178/400 (45%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcnkb	NP_062675.2	ClC_1_like	49..533	CDD:239655	217/486 (45%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	26/148 (18%)
		CBS repeat	552..627	CDD:341367	14/93 (15%)
		CBS repeat	633..675	CDD:341367	6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.800