Protein Alignment ClC-a and clcn2c

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001306200.1
• Gene: clcn2c / 563453
• ZFINID: ZDB-GENE-050506-73
• Length: 810
• Species: Danio rerio
• Alignment Length: 1024
• Identity: 336/1024 - (32%)
• Similarity: 505/1024 - (49%)
• Gaps: 257/1024 - (25%)

  Fly    91 DSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKR 155
            ::..:|::|       |..|.|||......|...        .||.|..|.|            .
Zfish     2 ENKGTDEND-------LERGIYTKSADRLGKGHC--------HRKSELNQSN------------N 39

  Fly   156 VSSWI---WRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTS-QPFVQYI 216
            ...||   .|..|:.:|.||:||.:||.|:..:||:||..:.:.|:|..|:|..:.. ...|||:
Zfish    40 CGVWIVHFHRLFVSLIGADWIFLMILGFILGTISFLMDIFVDLFTDAHRWIYYSVADYHVVVQYL 104

  Fly   217 AWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGM 281
            .|||..:.|:.|:|||.::::||::|||||||||.||||.::|||||:|||:||:.||..|||.:
Zfish   105 VWVSYSMILMCFAAGFANIVSPQAVGSGIPEMKTALRGVVMQEYLTFRTLVSKVVSLTCVLGSEL 169

  Fly   282 PLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEV 346
            |:|||||||||.|:.|.||.|.:..|..||:||:||.|:|...||||:|.|||:|:||.||||||
Zfish   170 PVGKEGPFVHIGSLCASLLCKFMALFSNIYKNEARNKELLTVGCAVGIGCCFASPIGGALFSIEV 234

  Fly   347 TTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLV 411
            |..|:..|||||.|.:|..||.:||||.||.:..:|:.||:.|.:..:||||.|||.||..:|:|
Zfish   235 TAMYYLPRNYWRAFLSATFGAIIFRLLPVWHREEETLMALYATKYRLDFPFDLQELPVFVAMGIV 299

  Fly   412 CGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHE 476
            ||||||.:|:::.:..||::..|..|..|.:|.|.|....::|:|:::||.|.|||:||:|:...
Zfish   300 CGLGGAFFVFLYGKITLFVKEKKASNSLLMRNCFYYSALTSVLISTLTFPPGFGQFMAGKLTQRY 364

  Fly   477 QVTQLFSNFTWSRDDLT--VEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFI 539
            .:...|.:.|||...:.  .:....:..|...|.:||..|.::.:..|.:|.::.|:|:|.|.|:
Zfish   365 SLISFFDDRTWSNHSIVKDFDDNDHLAAWKHPYANVFVVLFVFVIMKFWMSALSITLPIPCGSFV 429

  Fly   540 PVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMT 604
            |:|.||||||||:||.||..||.|....|.:.||:||.||||||||.:..||||:|.|||:.|:|
Zfish   430 PIFVIGAGFGRLIGEGMATLFPEGFNTDGHIYPIVPGAYAVVGAAALTAGVTHTMSTAVIMMELT 494

  Fly   605 GQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKY 669
            |.:::.:|::|:|:::|.|:..|||||||::|.||:|||||.|.........|.|||||.|||::
Zfish   495 GHLSYSLPILISVILSNMVSQSLQPSIYDTVIRIKRLPYLPLLRWGQRENSKIHVEDFMNRDVRF 559

  Fly   670 IWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQK 734
            |....:|:.:.::| .:..|:::|:|.|.::|:||||::|.:|:.:
Zfish   560 ITLNSTYRDVFKIL-CSGNLKTVPMVKSTESMLLLGSIERAQLLAL------------------- 604

  Fly   735 EAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSI 799
                                                                            :
Zfish   605 ----------------------------------------------------------------L 605

  Fly   800 LKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPA 864
            :::|.......|:.|              ..|:...::|.|                ::.|.|..
Zfish   606 IERTQYLRGGAYSIP--------------ARSKVHFQTATE----------------DSSSASAQ 640

  Fly   865 ASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNG 929
            .|         |||| :...::.|...                              ::.|:||.
Zfish   641 VS---------PSTP-LKSALKRPTAD------------------------------EEQLNNNV 665

  Fly   930 DSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVD 994
            ..|..|....|                 ||:                              .|.|
Zfish   666 YDSGLSFKTFF-----------------CSR------------------------------PDTD 683

  Fly   995 ETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERT 1059
            ...|.....:                ||..::.::||.:::.:.::..  :..|||:|||||:||
Zfish   684 AMKNDPDAHD----------------DMILQEIEKWEEQQLDEQVNFN--SCQIDPAPFQLVDRT 730

  Fly  1060 SILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPP 1108
            ::.|.||:||::.:::|:||.:|||||||.|.||.|||     ...:||
Zfish   731 TLHKTHSMFSVLNLDYAFVTSVGRLVGVVSLNELCKAI-----TGCMPP 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	231/477 (48%)
		Voltage_CLC	227..615	CDD:279048	191/389 (49%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	32/95 (34%)
clcn2c	NP_001306200.1	ClC_1_like	58..535	CDD:239655	230/476 (48%)
		Voltage_CLC	116..515	CDD:279048	195/398 (49%)
		CBS_pair_EriC_assoc_euk_bac	<719..767	CDD:239964	28/47 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	502	1.000	Domainoid score	I334
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	781	1.000	Inparanoid score	I505
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24854
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840