DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-a and clcn5a

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_001920783.2	Gene:	clcn5a / 562336	ZFINID:	ZDB-GENE-091113-15	Length:	811	Species:	Danio rerio

Alignment Length:	747	Identity:	212/747 - (28%)
Similarity:	339/747 - (45%)	Gaps:	160/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DSDSSDDDDPI--GYIDTLMYGRYTKDLGEFAKDEARKLKILEK-----------------RRKQ 136
            |..|:||..|:  .|...:.||     .||......:.:.:|::                 |.|.
Zfish    32 DFSSTDDVPPLDRDYGSGVSYG-----AGEGPNGIPKLMDLLDEPVPGVGTYEDFNTIDWVREKS 91

  Fly   137 EDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLS--------FIMDKGI 193
            :|:.|::|:..|     .:.|:|.....::.....|:.:.|:|::...|:        ::.|...
Zfish    92 KDRDRHREIAIK-----SKESTWALLKRISDAFSGWLLMLLVGLMSGALAGGIDISAHWMTDLKE 151

  Fly   194 SICTNA--------------------------RIW--LYRDLTSQPF---VQYIAWVSLPVCLIL 227
            .:|.|.                          :.|  |.....|.||   :.|:.:||..:....
Zfish   152 GVCLNGFWFNHEHCCWNSNETTFQERDKCPKWKSWAELIVGTNSGPFAYIMNYLMYVSWALLFSF 216

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            .:...|...||.:.||||||:||||.|..::.||...||:.|.|.|...:.||:.||||||.||:
Zfish   217 LAVSLVRAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVSSGLSLGKEGPLVHV 281

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            |...|.:|..|.|.::   .||::..|:|:||.||||...|.||:||||||:|..:.||.::..|
Zfish   282 ACCCANILCHLFTKYR---RNEAKRREVLSAAAAVGVSVAFGAPIGGVLFSLEEVSYYFPLKTLW 343

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASY--- 419
            |.||||:..|...|.:.. |.|:..|  ||...|.:  |:...||..|.|:|:..|:.||.:
Zfish   344 RSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHS--PWHLLELIPFILLGIFGGIWGAFFIRA 403

  Fly   420 -VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQFLAGELSTHEQVT 479
             :|..||     |...|:..        ||....|:|:::    :||....:     :||.|.::
Zfish   404 NIWWCRR-----RKTTRLGH--------YPVLEVLVVTAVTAVLAFPNSYTR-----MSTSELIS 450

  Fly   480 QLFS----------------NFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIA 528
            :||:                :.|.|..|...::.|    ....||::: .|.:..:|..:::::.
Zfish   451 ELFNDCGLLDSSQLCNYSNVSVTKSSSDALPDRPA----GPDVYTAMW-QLSLALIFKMLITVVT 510

  Fly   529 STIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP----IMPGGYAVVGAAAF 586
            ..:.:|||:|||...:||..|||:|   |.:|......|.:.|..||    |.||.||:|||.|.
Zfish   511 FGMKLPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWVIFRGWCSPGADCITPGLYAMVGATAC 575

  Fly   587 SGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKKLPYLP---- 645
            .|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..||::.|.:...|:|.
Zfish   576 LGGVTRMTVSLVVIMFELTGGLEYIVPLMAATMTSKWVADALGREGIYEAHIRLNGYPFLESKEE 640

  Fly   646 --------DLL--PSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPD 699
                    |::  ..|....|:..:|.| |.:|:.:....||.             ..|:|.|.:
Zfish   641 FSHKTLAMDVMRPRRSDPPLSVITQDGMNVEEVESLIAETSYS-------------GFPVVVSHE 692

  Fly   700 NMILLGSVQRYELIKMIEKHIGREKRMEVAQK 731
            :..|:|.|||.:|:..|:....|::.:..|.:
Zfish   693 SQRLVGFVQRRDLVISIDNARQRQEGVVSASR 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	172/558 (31%)
		Voltage_CLC	227..615	CDD:279048	146/419 (35%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
clcn5a	XP_001920783.2	ClC_3_like	129..635	CDD:239656	169/536 (32%)
		Voltage_CLC	213..615	CDD:279048	149/432 (34%)
		CBS	648..794	CDD:223591	21/90 (23%)
		CBS_pair_EriC_assoc_euk_bac	658..796	CDD:239964	19/80 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810