DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-a and clcn7

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001071005.1	Gene:	clcn7 / 553351	ZFINID:	ZDB-GENE-061103-196	Length:	795	Species:	Danio rerio

Alignment Length:	743	Identity:	187/743 - (25%)
Similarity:	315/743 - (42%)	Gaps:	174/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 WVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQ-------YIAWVSLPVCLILFS 229
            ||...|:|::..|::.::|..:......:.:..:. ..:.|.:       .|.|..|....::..
Zfish   114 WVICGLIGLLTGLIACLIDIAVENLAGLKYFAVKQ-NIEKFTELGGLSLSLILWAVLNSAFVMVG 177

  Fly   230 AGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIAS 294
            |..|....|.:.|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..:
Zfish   178 AIIVAFFEPIAAGSGIPQIKCYLNGVKVPRVVRLKTLVVKVFGVICSVAGGLAVGKEGPMIHSGA 242

  Fly   295 IVAQLLSK-----LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            :||..:|:     |...|: ::|...|::|   .::|..|.||.|.|.|||||||||:|...:::
Zfish   243 VVAAGVSQGRSTSLKKDFK-MFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFW 306

  Fly   352 AVRNYWRGFFAA-VCGATVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLV 411
            .....||.|||: |...|:...|:::.|....:.:..|.||    :....::..|:.:|.::|.:
Zfish   307 NQLLTWRIFFASMVSSFTLNFFLSIYHQKPGELSSPGLINFGRFDSDSVQYNLYEIPLFIIMGAL 371

  Fly   412 CGLGGASY----VW--------VHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISF---- 460
            .|:.||.:    .|        :||..:..|.:.                .:|.:.:::||
Zfish   372 GGMLGALFNLLNYWLTIFRIRYIHRPCLQVMEAM----------------LVAAVTATVSFAMIY 420

  Fly   461 ------PLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMT----SYTSVFGN-- 513
                  |||...       |.|...|||.        ...|..|:.|.:..    |..|:|.|
Zfish   421 FSTECQPLGPDH-------TEEYPLQLFC--------ADGEYNAMATAFFNTPERSVRSLFHNPP 470

  Fly   514 -------LVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMA-VTFPHGVRYGGRL 570
                   |.::||..|::::....:.|.:|:|||...|||.:|||.|..:: :|....:...
Zfish   471 GTYNPMTLGVFTLAYFLLAVWTYGLTVSAGVFIPSLLIGAAWGRLFGILLSFITTSKSIWAD--- 532

  Fly   571 SPIMPGGYAVVGAAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDS 634
                ||.||::|||| ..|.|..|:|:.||:.|.||.:|:..|:|:.::.|..|.......:||.
Zfish   533 ----PGKYALIGAAAQLGGIVRMTLSLTVILVEATGNVTYGFPIMLVLMTAKIVGDYFVEGLYDI 593

  Fly   635 IILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTL-------RSL 692
            .|.::.:|:|....|.:|  :.:...:.|...|      ..:.::::|..:...|       ...
Zfish   594 HIKLQSVPFLHWEAPPTS--HWLTAREVMSSQV------TCFNRIEKVGTIVDVLSNTSTNHNGF 650

  Fly   693 PLV------DSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVE 751
            |:|      |.|..  |.|.|.|.:||.:: ||              |...|||.....:: :::
Zfish   651 PVVTHVTEIDEPSK--LCGLVLRSQLIVLL-KH--------------KVFVERAFSRFSQR-KLQ 697

  Fly   752 LKMRRPS--RFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQP 814
            ||..|.:  ||                    ||   .:::|.|...|:.::..|...|
Zfish   698 LKDFRDAYPRF--------------------PP---IQSIHVSQDERECMMDLTEFMN------- 732

  Fly   815 MGHSPSITPYTTITGNSEFRIRSAFEAI 842
                |  ||||.....|..|:...|.|:
Zfish   733 ----P--TPYTVPQETSLPRVFKLFRAL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	144/530 (27%)
		Voltage_CLC	227..615	CDD:279048	126/437 (29%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
clcn7	NP_001071005.1	ClC_6_like	82..604	CDD:239657	143/529 (27%)
		Voltage_CLC	172..584	CDD:279048	129/450 (29%)
		CBS_pair_EriC_assoc_euk_bac	625..780	CDD:239964	39/184 (21%)
		CBS	729..>780	CDD:223591	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810