DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and ClC-c

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	218/757 - (28%)
Similarity:	331/757 - (43%)	Gaps:	178/757 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 HVQR--HPKIKSHAFYPCPPPAENA----RDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEAR 125
            |.||  |..:.:|:.:  ..|.:.|    ..||..||...||..:......:.:|:   |:|..|
  Fly   123 HNQRTMHQHVPTHSAF--GDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDI---ARDRMR 182

  Fly   126 KLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
            ...|::||:.                     |.|.........|..|:.:.|:||....::.::|
  Fly   183 HRYIVKKRQD---------------------SLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVD 226

  Fly   191 KGIS--------ICTNARIWLYRDLTSQP----------------------------------FV 213
            .|.|        ||..| .|..|:....|                                  ::
  Fly   227 IGASWMSDLKHGICPPA-FWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYI 290

  Fly   214 QYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLG 278
            .|:.|..|...|   ||..|.:.||.:.||||||:||||.|..::.||...||:.|.:||..::.
  Fly   291 WYVLWALLFASL---SASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVS 352

  Fly   279 SGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFS 343
            :|:.||||||.|||||.:..:.|.:   |.....||::..|:|:||.|.||...|.||:||||||
  Fly   353 AGLTLGKEGPMVHIASCIGNIFSHV---FPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFS 414

  Fly   344 IEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALI 408
            :|..:.||.::..||.||.|:..|.|.|.|.. |.|..:|  ||...:...:.|  .||..|..:
  Fly   415 LEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP-FGNEHSV--LFFVEYNKPWIF--FELIPFVFL 474

  Fly   409 GLVCGLGGASYVWVHRRYVLFMRSNK---RMNKFLQKNRFLYPG----FLALLVSSISFPLGTGQ 466
            |::.|:.|          ..|:::|.   |..||.:..:  ||.    |:.|:.:.|.:|   ..
  Fly   475 GIMGGVIG----------TFFIKANLWWCRYRKFSKLGQ--YPVMEVLFVTLVTAIICYP---NP 524

  Fly   467 FLAGELSTHEQVTQLFSNFT----------WSRDDLTVEQAAV-VTH---------WMTSYTSVF 511
            |.  .::.:|.:..|.|..:          :.|.::|...:.: ||.         |:...|.:.
  Fly   525 FT--RMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFIL 587

  Fly   512 GNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP- 572
              .:..|:|||       .:.||:|:|||...:||..||:||   |..|.::|:...:.|..:.
  Fly   588 --KLALTIFTF-------GMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADS 643

  Fly   573 --IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYD 633
              |.||.||||||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|. ||.:..|||
  Fly   644 NLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYD 708

  Fly   634 SIILIKKLPYLPD-------------LLPSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLK 684
            :.|.:...|:|..             :.|..:...::..:|.| |.||:.:        |||.
  Fly   709 AHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENL--------LKET-- 763

  Fly   685 LNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRM 726
               .....|:|.|.:|..|:|.|.|.:|    ...||..||:
  Fly   764 ---EHNGYPVVVSRENQYLVGFVLRRDL----NLAIGNAKRL 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	173/551 (31%)
		Voltage_CLC	227..615	CDD:279048	145/421 (34%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	170/541 (31%)
		Voltage_CLC	298..699	CDD:279048	150/437 (34%)
		CBS	738..876	CDD:223591	21/78 (27%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	21/75 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460701
Domainoid	1	1.000	102	1.000	Domainoid score	I344
eggNOG	1	0.900	-	-		E1_COG0038
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740