DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and ClC-b

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	192/721 - (26%)
Similarity:	309/721 - (42%)	Gaps:	148/721 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD---KGISICTN 198
            :|:|| |.|..:.|.| |.:..||            :|:. :|||.||::..:|   :.:||  .
  Fly   128 QDEQR-KRLTERFSLR-KDIIRWI------------IFIQ-IGIITALIACTIDIIIEELSI--R 175

  Fly   199 ARIWLY--------------RDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMK 249
            ...:||              |||    .:.|:.|:...:..:.|.|..|..|.|.:.|||||::|
  Fly   176 KYTFLYNSVKENVPLSDASDRDL----LIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVK 236

  Fly   250 TILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLS--KLVTSFQGI-- 310
            :.|.||::...:..|||..|.||:..::..|:..|||||.:|..::||..:|  |..|..:..
  Fly   237 SYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRI 301

  Fly   311 ---YENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRL 372
               :.::....:.:....|.||.|.|.||:||:|||:|...:::.....||...|::.......:
  Fly   302 FKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNI 366

  Fly   373 LAVWFQ--NADTVRALF-LTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNK 434
            :...:.  |..|...|| |..|.|...||..||.:|.::|:..||.||::          ...|.
  Fly   367 VLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAW----------NSLNT 421

  Fly   435 RMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLA-------------GELSTHEQVTQLFSNFT 486
            ::|||  :.||: |..:..::.::...: .|..||             |...|:..| |||
  Fly   422 KINKF--RKRFI-PWKIGKVLEAVVVAM-MGVTLACLMIYFINDCRPLGNDPTNNPV-QLF---- 477

  Fly   487 WSRDDLTVEQAAVVTHWM----TSYTSVFGN---------LVIYTLFTFVVSIIASTIPVPSGMF 538
             ..|:   |..||...|.    .:..|:|.:         |.::|:..:|:|.....:.|..|:|
  Fly   478 -CEDN---EYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVF 538

  Fly   539 IPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFE 602
            ||...:||.:|||:.......||       :...:.||.||::||||..|.|.. |:|::||:.|
  Fly   539 IPTALVGAAWGRLLAMLTYYVFP-------QAEFLHPGKYALIGAAANLGGVLRMTISLSVILME 596

  Fly   603 MTG-QITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLP-DLLPSSSGM-----YSIFVE 660
            .|| :.:...|::||::.|..|.......|||:.|.:..:|.|. :.||...|:     .|..|.
  Fly   597 TTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVI 661

  Fly   661 DFMVRD-VKYIWHGISYQKLKEVLKLNKTLRSLPLVDS-----PDNMILLGSVQRYELIKMIEKH 719
            ...:|| ..||     |:.||:.     .....|:||.     .....:.|.:.|.:||.::.|.
  Fly   662 CIKIRDSANYI-----YEMLKKC-----DHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKS 716

  Fly   720 IGREKRMEVAQKWQKEAQERALE---------------EEKKKQEVELKM-RRPSRFEVLPAPDI 768
            :..|.:    :.|..|...:...               :||....|:|.| ..||...|.|...:
  Fly   717 LYVENK----RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSV 777

  Fly   769 LSLRQI 774
            ..:.||
  Fly   778 PRIFQI 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	148/530 (28%)
		Voltage_CLC	227..615	CDD:279048	122/425 (29%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	24/119 (20%)
		ClC_6_like	115..639	CDD:239657	157/561 (28%)
		Voltage_CLC	213..620	CDD:279048	126/436 (29%)
		CBS	653..811	CDD:223591	31/145 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460700
Domainoid	1	1.000	102	1.000	Domainoid score	I344
eggNOG	1	0.900	-	-		E1_COG0038
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740