DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcn6

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001099949.1	Gene:	Clcn6 / 295586	RGDID:	1305379	Length:	870	Species:	Rattus norvegicus

Alignment Length:	1077	Identity:	223/1077 - (20%)
Similarity:	389/1077 - (36%)	Gaps:	351/1077 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GEFAKDEARKLKILEKRRKQEDKQRNK-----------------ELLGKHSTRAKRVSSWIWRHT 164
            ||.......:|.||.:.:::||:...:                 |:|.....:..|      ||.
  Rat    19 GERESRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGR------RHE 77

  Fly   165 VARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL-- 227
            ..:    |:.:..:|:...|:...:|..:.:.|..:..:.:....:        .|...||.|
  Rat    78 AVK----WMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSVEE--------CSQKGCLALSL 130

  Fly   228 -----------FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGM 281
                       |.|..:.||.|.:.||||||:|..|.||::...:..:||:.||.|:..::..|:
  Rat   131 LELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVAGGL 195

  Fly   282 PLGKEGPFVHIASIVAQLLSKLVTSFQGI-----------YENESRNSEMLAAACAVGVGACFAA 335
            .:|||||.:|..::|...|.:    ||.|           :.::....:.::|..|.||.|.|.|
  Rat   196 FVGKEGPMIHSGAVVGAGLPQ----FQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256

  Fly   336 PVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLL--AVWFQNADTVRALFLTNFTTEFP-- 396
            |:||.|||:|..::::.....|:..|.::.........  .:.|.:....:...|.|| .||.
  Rat   257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAFQLPGLLNF-GEFKCS 320

  Fly   397 --------FDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFL-- 451
                    :...:|..|.::|::.||.||:          |...|||:.|:..:|....|..:
  Rat   321 DSDKKCHLWTAMDLGFFVVMGVIGGLLGAT----------FNCLNKRLAKYRMRNVHPKPKLVRV 375

  Fly   452 --ALLVSSI--------SFPLG-------TGQFLAGELS---THEQVTQLFSNFTWSRD---DLT 493
              :||||.:        |..||       |.|...|...   |.|.|......|....|   |:.
  Rat   376 LESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFCPNDTYNDMA 440

  Fly   494 V-----EQAAVVT--HWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRL 551
            .     :::|::.  |...:::.|  .|.::....|:::.......||||:|:|....||.||||
  Rat   441 TLFFNSQESAILQLFHQDGTFSPV--TLALFFALYFLMACWTFGTSVPSGLFVPSLLCGAAFGRL 503

  Fly   552 VGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMI 615
            |...:.       .|.| |..:..|.:|::|||||.|.|.. |:|:.||:.|.|.:||:.:|:|:
  Rat   504 VANVLK-------SYIG-LGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMV 560

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLP-------DLLPSSSGMYSIFVEDFMVRDVKYIWHG 673
            .::||..........|||..|.::.:|.|.       |.|.:|         |.|..::.|::..
  Rat   561 TLMVAKWTGDFFNKGIYDIHIGLRGVPLLEWETEVEMDRLRAS---------DIMEPNLTYVYPH 616

  Fly   674 ISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR-MEVAQ------K 731
            ...|.|..:|:...                      :....::.::.|.||. |:..|      |
  Rat   617 TRIQSLVSILRTTV----------------------HHAFPVVTENRGNEKEFMKGNQLISNNIK 659

  Fly   732 WQKEA-QERALEEEKKKQEVELKMRRPSRFEVLPAPDILSL--RQIANDEMLPPKKRAETMHGSL 793
            ::|.: ..||.|:.|:.|.:          :..|:.::.::  ..:|::|   |.::.:.:...|
  Rat   660 FKKSSILTRAGEQRKRGQSM----------KSYPSSELRNVCDEHVASEE---PAEKEDLLQQML 711

  Fly   794 APRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPET 858
            ..|                        .|||                         .::.||.
  Rat   712 ERR------------------------YTPY-------------------------PNLYPDQ-- 725

  Fly   859 GSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDK 923
               ||:......|..|..:..|:..:.||            :.|.|..:....::
  Rat   726 ---SPSEDWTMEERFRPLTFHGLVLRSQL------------VTLLVRGVCYSESQ---------- 765

  Fly   924 ALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGY 988
                   ||...|.:.: |....|..|.|
  Rat   766 -------SSASQPRLSY-AEMAEDYPRFP------------------------------------ 786

  Fly   989 SIEDVDET-TNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSP 1052
            .|.|:|.| .||                 ..::|::|                      :::|||
  Rat   787 DIHDLDLTLLNP-----------------RMIVDVTP----------------------YMNPSP 812

  Fly  1053 FQLVERTSILKVHSLFSMVGINH-AYVTKIGRLVGVV 1088
            |.:...|.:.:|.:||..:|:.| ..|..:|.:||::
  Rat   813 FTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGII 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	141/550 (26%)
		Voltage_CLC	227..615	CDD:279048	124/456 (27%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	16/90 (18%)
Clcn6	NP_001099949.1	ClC_6_like	49..589	CDD:239657	145/582 (25%)
		Voltage_CLC	140..571	CDD:279048	126/455 (28%)
		CBS	609..656	CDD:214522	9/68 (13%)
		CBS_pair_EriC_assoc_euk_bac	<801..854	CDD:239964	16/71 (23%)
		CBS	804..>854	CDD:223591	15/68 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810