DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and Clcn7

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_113756.1 Gene:Clcn7 / 29233 RGDID:61836 Length:803 Species:Rattus norvegicus


Alignment Length:786 Identity:197/786 - (25%)
Similarity:334/786 - (42%) Gaps:162/786 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 FAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE--DWVFLALLGII 181
            |.|:.....|:|..:.:..|...::..|.....|  |::     ||..|..|  .||..||:||:
  Rat    77 FPKEIPHNEKLLSLKYESLDYDNSENQLFLEEER--RIN-----HTAFRTVEIKRWVICALIGIL 134

  Fly   182 MALLSFIMDKGISICTNARIWLYRD----LTSQPFVQY--IAWVSLPVCLILFSAGFVHLIAPQS 240
            ..|::..:|..:......:..:.:|    .|.:..:.:  :.|.:|....:|..:..|..|.|.:
  Rat   135 TGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVA 199

  Fly   241 IGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSK--- 302
            .|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..|::|..:|:   
  Rat   200 AGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRS 264

  Fly   303 --LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFA 362
              |...|: |:|...|::|   .::|..|.||.|.|.|||||||||:|...:::.....||.|||
  Rat   265 TSLKRDFK-IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 328

  Fly   363 AVCGA-TVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ::... |:..:|:::..|...:.:..|.||    :.:..:...|:.||..:|:|.|:.||     
  Rat   329 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGA----- 388

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFL----ALLV-----------------------SSISF 460
                 :|...|..:..|  :.|:::...|    |:||                       ||:|:
  Rat   389 -----VFNALNYWLTMF--RIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSY 446

  Fly   461 PL----GTGQF---LAGELSTHEQ-VTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
            ||    ..|::   .|...:|.|: |..||.:...|.:.:|                    |.::
  Rat   447 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMT--------------------LGLF 491

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVG 582
            ||..|.::.....:.|.:|:|||...|||.:|||.|  :::::..|......     ||.||::|
  Rat   492 TLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG--ISMSYLTGAAIWAD-----PGKYALMG 549

  Fly   583 AAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPD 646
            ||| ..|.|..|:|:.||:.|.|..:|:..|:|:.::.|..|..:....:||..|.::.:|:|..
  Rat   550 AAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHW 614

  Fly   647 LLPSSSGMYSIFVEDFMVRDVKYIWH----GISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSV 707
            ..|.:|  :|:...:.|...|..:..    ||....|.:....:.....:..|.......|.|.:
  Rat   615 EAPVTS--HSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLI 677

  Fly   708 QRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPA-PDILSL 771
            .|.:||.:: ||                   :...|......|:.::|.....:..|. |.|.|:
  Rat   678 LRSQLIVLL-KH-------------------KVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSI 722

  Fly   772 RQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIR 836
             .::.||      |..||                 :|..:..|       :|||.....|..|:.
  Rat   723 -HVSQDE------RECTM-----------------DLSEFMNP-------SPYTVPQEASLPRVF 756

  Fly   837 SAFEAI 842
            ..|.|:
  Rat   757 KLFRAL 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 148/529 (28%)
Voltage_CLC 227..615 CDD:279048 128/436 (29%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964
Clcn7NP_113756.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
ClC_6_like 93..618 CDD:239657 156/571 (27%)
Voltage_CLC 183..593 CDD:279048 131/449 (29%)
Selectivity filter part_1. /evidence=ECO:0000250 201..205 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 243..247 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 510..514 2/3 (67%)
CBS_pair_EriC_assoc_euk_bac 634..788 CDD:239964 32/180 (18%)
CBS 736..>793 CDD:223591 8/34 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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