DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcn7

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_036060.1	Gene:	Clcn7 / 26373	MGIID:	1347048	Length:	803	Species:	Mus musculus

Alignment Length:	786	Identity:	197/786 - (25%)
Similarity:	334/786 - (42%)	Gaps:	162/786 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 FAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE--DWVFLALLGII 181
            |.|:.....|:|..:.:..|...::..|.....|  |::     ||..|..|  .||..||:||:
Mouse    77 FPKEIPHNEKLLSLKYESLDYDNSENQLFLEEER--RIN-----HTAFRTVEIKRWVICALIGIL 134

  Fly   182 MALLSFIMDKGISICTNARIWLYRD----LTSQPFVQY--IAWVSLPVCLILFSAGFVHLIAPQS 240
            ..|::..:|..:......:..:.:|    .|.:..:.:  :.|.:|....:|..:..|..|.|.:
Mouse   135 TGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVA 199

  Fly   241 IGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSK--- 302
            .|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..|::|..:|:
Mouse   200 AGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRS 264

  Fly   303 --LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFA 362
              |...|: |:|...|::|   .::|..|.||.|.|.|||||||||:|...:::.....||.|||
Mouse   265 TSLKRDFK-IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 328

  Fly   363 AVCGA-TVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ::... |:..:|:::..|...:.:..|.||    :.:..:...|:.||..:|:|.|:.||
Mouse   329 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGA----- 388

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFL----ALLV-----------------------SSISF 460
                 :|...|..:..|  :.|:::...|    |:||                       ||:|:
Mouse   389 -----VFNALNYWLTMF--RIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSY 446

  Fly   461 PL----GTGQF---LAGELSTHEQ-VTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
            ||    ..|::   .|...:|.|: |..||.:...|.:.:|                    |.::
Mouse   447 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMT--------------------LGLF 491

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVG 582
            ||..|.::.....:.|.:|:|||...|||.:|||.|  :::::..|......     ||.||::|
Mouse   492 TLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG--ISLSYLTGAAIWAD-----PGKYALMG 549

  Fly   583 AAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPD 646
            ||| ..|.|..|:|:.||:.|.|..:|:..|:|:.::.|..|..:....:||..|.::.:|:|..
Mouse   550 AAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHW 614

  Fly   647 LLPSSSGMYSIFVEDFMVRDVKYIWH----GISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSV 707
            ..|.:|  :|:...:.|...|..:..    ||....|.:....:.....:..|.......|.|.:
Mouse   615 EAPVTS--HSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLI 677

  Fly   708 QRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPA-PDILSL 771
            .|.:||.:: ||                   :...|......|:.::|.....:..|. |.|.|:
Mouse   678 LRSQLIVLL-KH-------------------KVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSI 722

  Fly   772 RQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIR 836
             .::.||      |..||                 :|..:..|       :|||.....|..|:.
Mouse   723 -HVSQDE------RECTM-----------------DLSEFMNP-------SPYTVPQEASLPRVF 756

  Fly   837 SAFEAI 842
            ..|.|:
Mouse   757 KLFRAL 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	148/529 (28%)
		Voltage_CLC	227..615	CDD:279048	128/436 (29%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcn7	NP_036060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		ClC_6_like	93..618	CDD:239657	156/571 (27%)
		Selectivity filter part_1. /evidence=ECO:0000250	201..205		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	243..247		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	510..514		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	624..788	CDD:341367	34/190 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810