DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and Clcn5

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:XP_038955439.1 Gene:Clcn5 / 25749 RGDID:2362 Length:816 Species:Rattus norvegicus


Alignment Length:760 Identity:220/760 - (28%)
Similarity:336/760 - (44%) Gaps:187/760 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 SDSSDDD--------------DPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK---------- 132
            |.|||:|              |.:..:|..:.|..:.:.|...... |.:..||:          
  Rat    23 SSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSN-RIMDFLEEPIPGVGTYDD 86

  Fly   133 -------RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
                   |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|
  Rat    87 FNTIDWVREKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLID 146

  Fly   191 ----------KGI----------SICTNARIWLYRDLTSQP----------------------FV 213
                      :||          ..|.|:....:.|....|                      :.
  Rat   147 ISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEDRDKCPEWNSWSQLIISTDQGAFAYIVNYF 211

  Fly   214 QYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLG 278
            .|:.|..|   ....:...|...||.:.||||||:||||.|..::.||...|||.|.|.|...:.
  Rat   212 MYVLWALL---FAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVS 273

  Fly   279 SGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFS 343
            ||:.||||||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:||||||
  Rat   274 SGLSLGKEGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFS 335

  Fly   344 IEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALI 408
            :|..:.||.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|.::
  Rat   336 LEEVSYYFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPFIVL 395

  Fly   409 GLVCGLGGASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFPLGT 464
            |:..||.||          ||:|:|     ||....|.|    ||....|:|::|    :||   
  Rat   396 GIFGGLWGA----------LFIRTNIAWCRKRKTTQLGK----YPVVEVLIVTAITAILAFP--- 443

  Fly   465 GQFLAGELSTHEQVTQLF---------------SNFTWSR-DDLTVEQAAVVTH---WMTSYTSV 510
            .::.  .:||.|.:::||               ::|..|: .:|....|.|..:   |..:.|.:
  Rat   444 NEYT--RMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGVYSAMWQLALTLI 506

  Fly   511 FGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFM-AVTFPH---GVRYGGRLS 571
            .  .::.|:|||.:.|       |||:|||...:||..|||:|..| .:.:.|   |: :....|
  Rat   507 L--KIVITIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGI-FNSWCS 561

  Fly   572 P----IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPS 630
            .    |.||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..
  Rat   562 QGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREG 626

  Fly   631 IYDSIILIKKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQKLK 680
            |||:.|.:...|:|.            |::.  .:..:.::..:|.| |.||             
  Rat   627 IYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV------------- 678

  Fly   681 EVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725
            |.:....|....|:|.|.::..|:|.|.|.:||..||.  .|:|:
  Rat   679 ETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 177/566 (31%)
Voltage_CLC 227..615 CDD:279048 151/424 (36%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964
Clcn5XP_038955439.1 ClC_3_like 142..640 CDD:239656 172/537 (32%)
CBS_pair_voltage-gated_CLC_euk_bac 651..801 CDD:341367 21/86 (24%)
CBS repeat 657..752 CDD:341367 20/80 (25%)
CBS repeat 758..800 CDD:341367
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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