Protein Alignment ClC-a and clh-1

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001382719.1
• Gene: clh-1 / 174821
• WormBaseID: WBGene00000528
• Length: 973
• Species: Caenorhabditis elegans
• Alignment Length: 1140
• Identity: 348/1140 - (30%)
• Similarity: 510/1140 - (44%)
• Gaps: 298/1140 - (26%)

  Fly    14 DRSNQKVE-RIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEE---------ELRHV 68
            |.|..|:| .::.|||......:...|..:.....|.|...|.:  |.||:         |....
 Worm    62 DGSILKMEDAVVVDEEHRRRGEDTQSSGQSSLPSDIVQFTARPH--MLMEDVECSPIEPTEKEWN 124

  Fly    69 QRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKR 133
            :...:::.:|     ...|...|.:|||.:|             ..||.|..:|       ....
 Worm   125 EYRDRVQENA-----DQMELLGDDESSDTED-------------QNDLDEEYED-------YYTD 164

  Fly   134 RKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTN 198
            .|...::..||.|.:.           :::.|....|||...|.||.|.|:.|..:|.||....:
 Worm   165 SKSTRRETTKEFLTRQ-----------FQNIVHFFVEDWFISAALGFITAIFSIFIDMGIEYLIH 218

  Fly   199 ARIWLYRDLTSQPFVQYIA---WVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEY 260
            .|.::...|  :.|..|.|   ||.....|:..:|...:....|::||||||:|.|:.|.|||.|
 Worm   219 FRNFMLESL--EQFNNYAAFCGWVFYITGLVYLAALVCYGFGKQAVGSGIPEVKVIIHGFQLKNY 281

  Fly   261 LTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTS--FQGIYENESRNSEMLAA 323
            |:.|||:||:||||.|:|||:|:|||||||||.:|||.||:|:..:  :...:.||.|..|||:.
 Worm   282 LSGKTLIAKMIGLTLTIGSGLPVGKEGPFVHIGAIVASLLNKVTAACQYNAFFSNEGRAMEMLSI 346

  Fly   324 ACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWF---QNADTVRA 385
            .||||:...|:||:|.||:.||.|:.||||:||||.|||..|.|.:||....:|   ..|.|:.|
 Worm   347 GCAVGIACTFSAPMGAVLYGIESTSKYFAVKNYWRSFFATTCSAMLFRFAIAFFVPQHIAGTITA 411

  Fly   386 LFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGF 450
            .:.|.|..|. |..:||..|..:|::.||.||.:|:.|||...|.|.|:.......|:..|:...
 Worm   412 YYQTYFPNEV-FVVEELPFFIGLGVMTGLLGALFVYYHRRIAFFKRKNRIFQALFGKSPILFTAC 475

  Fly   451 LALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFT-WSRDDLTVEQAAVVTHWMTSYTSVFG-- 512
            .|.:.:.:.:|.|.|.::||:.:..|.:....||.| |.:   |........|.:..::...|
 Worm   476 CAAIFAVLVYPNGLGSYVAGKYTFRETLVDFLSNCTLWKQ---TNGSEGCPPHMLEHWSGPEGDM 537

  Fly   513 ----NLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPI 573
                :|:||.||.|::..|..|:.:|||:|:|.|.|||..||:.||.:::.:|:|:|..|: ..|
 Worm   538 MPINSLLIYFLFYFIIVPICITLYIPSGIFVPCFVIGACGGRIFGEIISMIWPYGLRGLGQ-PQI 601

  Fly   574 MPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILI 638
            .||.|||||||:|:|||||::|:|:|:.|.|||:..::||:||::::||:.|.||||||||||.|
 Worm   602 YPGLYAVVGAASFTGSVTHSLSIALIVCETTGQLCALLPVLIALMISNAICAFLQPSIYDSIIKI 666

  Fly   639 KKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMIL 703
            ...|||.||.||...::.:.||..||:|:.||....:|::|:|:|..:.||||.|.|....:|.|
 Worm   667 NGYPYLADLPPSRMSVHQMKVERIMVKDIFYITRETTYRELREMLLESPTLRSYPFVTDSRSMTL 731

  Fly   704 LGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDI 768
            ||||.|..|:.:|::.:|.|..:                         ...||.||    .|.:|
 Worm   732 LGSVARKYLLYLIQRKLGPEPEL-------------------------FGHRRRSR----TASEI 767

  Fly   769 LSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEF 833
            .|  .|.|       .|..:..||||...:.:...|               ::.....|:||
 Worm   768 FS--TINN-------LRKYSRRGSLAANGAHMSSGN---------------ALMTDRNISGN--- 805

  Fly   834 RIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTD 898
                                      :|.|.:..||.:..|:|..|      .|.||:|
 Worm   806 --------------------------TLLPQSPLHEDQGDRSPLAP------LLYAQTN------ 832

  Fly   899 QIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRF 963
                |..||
 Worm   833 ----QHEPI-------------------------------------------------------- 837

  Fly   964 ANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQK 1028
                                               ..|||:
 Worm   838 -----------------------------------VHSLAK------------------------ 843

  Fly  1029 QWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKEL 1093
              ..|.:.|.:|:::  |.|||:|||||..||:.|||:|||::.:||||||:.|||.|||.:|||
 Worm   844 --RAEILSKKLDMEE--VAIDPAPFQLVRGTSLYKVHTLFSLLALNHAYVTEKGRLCGVVAVKEL 904

  Fly  1094 RKAIEDINSNSFVPPTR-----------DEDADEK 1117
            |:|:.:|.|...|.|.:           ::|.|.:
 Worm   905 REALSNIYSRGAVVPKQRIRTSTFRLNPEQDLDRE 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	206/489 (42%)
		CBS_pair_SF	659..>718	CDD:449531	26/58 (45%)
		CBS repeat	664..715	CDD:341358	22/50 (44%)
		CBS_pair_SF	<1032..1096	CDD:449531	36/63 (57%)
		CBS repeat	1053..1095	CDD:341358	27/41 (66%)
clh-1	NP_001382719.1	ClC_1_like	191..674	CDD:239655	206/489 (42%)
		CBS_pair_voltage-gated_CLC_euk_bac	687..907	CDD:341367	99/436 (23%)
		CBS repeat	692..858	CDD:341367	63/382 (16%)
		CBS repeat	864..906	CDD:341367	27/41 (66%)