Protein Alignment ClC-a and clh-1

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001022373.1
• Gene: clh-1 / 174821
• WormBaseID: WBGene00000528
• Length: 906
• Species: Caenorhabditis elegans
• Alignment Length: 1132
• Identity: 344/1132 - (30%)
• Similarity: 506/1132 - (44%)
• Gaps: 297/1132 - (26%)

  Fly    21 ERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEE---------ELRHVQRHPKIKS 76
            :.::.|||......:...|..:.....|.|...|.:  |.||:         |....:...:::.
 Worm     3 DAVVVDEEHRRRGEDTQSSGQSSLPSDIVQFTARPH--MLMEDVECSPIEPTEKEWNEYRDRVQE 65

  Fly    77 HAFYPCPPPAENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQR 141
            :|     ...|...|.:|||.:|             ..||.|..:|       .....|...::.
 Worm    66 NA-----DQMELLGDDESSDTED-------------QNDLDEEYED-------YYTDSKSTRRET 105

  Fly   142 NKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRD 206
            .||.|.:.           :::.|....|||...|.||.|.|:.|..:|.||....:.|.::...
 Worm   106 TKEFLTRQ-----------FQNIVHFFVEDWFISAALGFITAIFSIFIDMGIEYLIHFRNFMLES 159

  Fly   207 LTSQPFVQYIA---WVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVA 268
            |  :.|..|.|   ||.....|:..:|...:....|::||||||:|.|:.|.|||.||:.|||:|
 Worm   160 L--EQFNNYAAFCGWVFYITGLVYLAALVCYGFGKQAVGSGIPEVKVIIHGFQLKNYLSGKTLIA 222

  Fly   269 KVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTS--FQGIYENESRNSEMLAAACAVGVGA 331
            |:||||.|:|||:|:|||||||||.:|||.||:|:..:  :...:.||.|..|||:..||||:..
 Worm   223 KMIGLTLTIGSGLPVGKEGPFVHIGAIVASLLNKVTAACQYNAFFSNEGRAMEMLSIGCAVGIAC 287

  Fly   332 CFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWF---QNADTVRALFLTNFTT 393
            .|:||:|.||:.||.|:.||||:||||.|||..|.|.:||....:|   ..|.|:.|.:.|.|..
 Worm   288 TFSAPMGAVLYGIESTSKYFAVKNYWRSFFATTCSAMLFRFAIAFFVPQHIAGTITAYYQTYFPN 352

  Fly   394 EFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI 458
            |. |..:||..|..:|::.||.||.:|:.|||...|.|.|:.......|:..|:....|.:.:.:
 Worm   353 EV-FVVEELPFFIGLGVMTGLLGALFVYYHRRIAFFKRKNRIFQALFGKSPILFTACCAAIFAVL 416

  Fly   459 SFPLGTGQFLAGELSTHEQVTQLFSNFT-WSRDDLTVEQAAVVTHWMTSYTSVFG------NLVI 516
            .:|.|.|.::||:.:..|.:....||.| |.:   |........|.:..::...|      :|:|
 Worm   417 VYPNGLGSYVAGKYTFRETLVDFLSNCTLWKQ---TNGSEGCPPHMLEHWSGPEGDMMPINSLLI 478

  Fly   517 YTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVV 581
            |.||.|::..|..|:.:|||:|:|.|.|||..||:.||.:::.:|:|:|..|: ..|.||.||||
 Worm   479 YFLFYFIIVPICITLYIPSGIFVPCFVIGACGGRIFGEIISMIWPYGLRGLGQ-PQIYPGLYAVV 542

  Fly   582 GAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPD 646
            |||:|:|||||::|:|:|:.|.|||:..::||:||::::||:.|.||||||||||.|...|||.|
 Worm   543 GAASFTGSVTHSLSIALIVCETTGQLCALLPVLIALMISNAICAFLQPSIYDSIIKINGYPYLAD 607

  Fly   647 LLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYE 711
            |.||...::.:.||..||:|:.||....:|::|:|:|..:.||||.|.|....:|.|||||.|..
 Worm   608 LPPSRMSVHQMKVERIMVKDIFYITRETTYRELREMLLESPTLRSYPFVTDSRSMTLLGSVARKY 672

  Fly   712 LIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIAN 776
            |:.:|::.:|.|..:                         ...||.||    .|.:|.|  .|.|
 Worm   673 LLYLIQRKLGPEPEL-------------------------FGHRRRSR----TASEIFS--TINN 706

  Fly   777 DEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEA 841
                   .|..:..||||...:.:...|               ::.....|:||
 Worm   707 -------LRKYSRRGSLAANGAHMSSGN---------------ALMTDRNISGN----------- 738

  Fly   842 IFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNP 906
                              :|.|.:..||.:..|:|..|      .|.||:|          |..|
 Worm   739 ------------------TLLPQSPLHEDQGDRSPLAP------LLYAQTN----------QHEP 769

  Fly   907 ISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNG 971
            |
 Worm   770 I---------------------------------------------------------------- 770

  Fly   972 SPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEML 1036
                                       ..|||:                          ..|.:.
 Worm   771 ---------------------------VHSLAK--------------------------RAEILS 782

  Fly  1037 KPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDIN 1101
            |.:|:::  |.|||:|||||..||:.|||:|||::.:||||||:.|||.|||.:||||:|:.:|.
 Worm   783 KKLDMEE--VAIDPAPFQLVRGTSLYKVHTLFSLLALNHAYVTEKGRLCGVVAVKELREALSNIY 845

  Fly  1102 SNSFVPPTR-----------DEDADEK 1117
            |...|.|.:           ::|.|.:
 Worm   846 SRGAVVPKQRIRTSTFRLNPEQDLDRE 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	206/489 (42%)
		Voltage_CLC	227..615	CDD:279048	168/399 (42%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	39/95 (41%)
clh-1	NP_001022373.1	ClC_1_like	124..607	CDD:239655	206/489 (42%)
		Voltage_CLC	182..585	CDD:279048	172/407 (42%)
		CBS_pair_EriC_assoc_euk_bac	<768..840	CDD:239964	41/190 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14197
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920