DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and clh-2

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001364585.1	Gene:	clh-2 / 174738	WormBaseID:	WBGene00000529	Length:	878	Species:	Caenorhabditis elegans

Alignment Length:	1113	Identity:	364/1113 - (32%)
Similarity:	544/1113 - (48%)	Gaps:	269/1113 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 YPCPPP-----AENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDK 139
            :|.||.     |...:|.|::...|....:..:..|..|.|..|                :.:|.
Worm    13 FPAPPTSIAVIATTNKDIDNNVMSDVKRSLLDMSPGGKTDDADE----------------EPDDH 61

  Fly   140 QRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLY 204
            ..:.|...:..||..       ::.|..|.|||...||||||.|:||..||..|.:..:|.:..|
Worm    62 VESNETFAEFCTRQA-------QNVVHFLVEDWFLSALLGIITAVLSVGMDVAIEVLQHAHVTFY 119

  Fly   205 -RDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVA 268
             :.|....::.:..||:..|.|.:|:|.|..:::.|::||||||:|.|:.|.:::.|||.:||||
Worm   120 DKMLAISSYLAFSQWVAHIVILTMFAAIFCQIVSKQAVGSGIPEVKVIMHGFKMENYLTTRTLVA 184

  Fly   269 KVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTS--FQGIYENESRNSEMLAAACAVGVGA 331
            |::|||..:|.|:|:||||||||:.:|||.||||:.::  :...:.||.|..|||::.||||:..
Worm   185 KMVGLTLAMGGGLPIGKEGPFVHMGAIVATLLSKITSACQYSAFFSNEGREMEMLSSGCAVGIAC 249

  Fly   332 CFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNAD---TVRALFLTNFTT 393
            .|:||:|.||::||.|:.||||:||||||.||.|.|.||| .|.:|..|:   |:.|.:.|.|.|
Worm   250 TFSAPIGAVLYAIESTSKYFAVKNYWRGFLAATCSAIVFR-CANFFVTAEQSGTITAFYQTRFPT 313

  Fly   394 EFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFL-YPGFLALLVSS 457
            :. |..:||.:|.|:|.:.||.|:.::::||:..:| ||..|:.|.:.:|.|| :..|:|.:|..
Worm   314 DC-FLVEELPIFLLLGFISGLMGSFFIFIHRQISIF-RSKNRVYKLIFRNNFLAFTVFMAFVVGV 376

  Fly   458 ISFPLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHW---MTSYTSVFGNLVIYTL 519
            ::||.|.|::.||.|:..|.:...|:|.||..:|.......::|||   .....|:|.:||:|.:
Worm   377 LTFPNGLGRYFAGRLTFRETMADFFNNCTWVSNDSRRCPDTILTHWTGGSEGDVSIFTSLVLYYI 441

  Fly   520 FTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAA 584
            ..||:..|..:|.||:|:|:|.|.|||..|||:||.|.|.||.|:|..|. .||.||.|||||||
Worm   442 LYFVLVAICISINVPAGVFVPSFIIGAAGGRLMGETMVVLFPEGMRGPGG-PPIHPGLYAVVGAA 505

  Fly   585 AFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLP 649
            |::|:||||:||:|||.|:|||::.::||:||:|:.|||...||||||:|||.:||.||||||.|
Worm   506 AYTGAVTHTLSVSVIICELTGQLSPILPVLIAMLMGNAVCKFLQPSIYESIIRVKKYPYLPDLPP 570

  Fly   650 SSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIK 714
            |...::::.||..||.||.||...::|:::||:|:|...|||.|:|...:|.||||||.:..|..
Worm   571 SRVSVHTVKVEQLMVTDVIYITKDMTYREMKEILQLAPHLRSFPIVTDHENKILLGSVAKRYLTM 635

  Fly   715 MIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEM 779
            ::.:|:
Worm   636 LLRRHV----------------------------------------------------------- 641

  Fly   780 LPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFK 844
                               ::.:.:|.|:          ..:||       ||.     |..|.:
Worm   642 -------------------LVNQQDSRNI----------GRMTP-------SEI-----FNTIRR 665

  Fly   845 KSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPIST 909
            .|..|....|...:.|    :...|..||.|..:...|.:|:..::..   ::...:|.::|:..
Worm   666 TSMRLSRRSPSRRSNS----SQTRENSVPETARSDAPSDQVEFVSERT---ISGNTLLSISPLHC 723

  Fly   910 ESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPT 974
            .:| :|.:..||             .||       .||:                       |.|
Worm   724 PNN-IPLQAVFT-------------RPS-------SADL-----------------------SKT 744

  Fly   975 RTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPI 1039
            .|...|    :|..:| |:||
Worm   745 ETNADI----LLNRNI-DLDE-------------------------------------------- 760

  Fly  1040 DLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNS 1104
                  :.||.:|||||..:|:.|||:|||::|::|||||..|:|||||||||||.|:.:|....
Worm   761 ------IAIDAAPFQLVLGSSLYKVHTLFSLLGLSHAYVTDCGKLVGVVGLKELRDAMANIYVRG 819

  Fly  1105 FVPPTRDEDADEKPAVEKPLLSTNSSDKAVDMTVTSMDSALSNSE----NCSDIEMEHIKHTDKG 1165
            .|.|.       ||  ::.|    :|...:||:..:.|..|:..:    |...|.||..|..:
Worm   820 AVAPV-------KP--DRKL----TSGTFLDMSHMNKDKLLNTPQTPPANGLSINMESPKFGN-- 869

  Fly  1166 TVSLTMPP 1173
              |||:||
Worm   870 --SLTVPP 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	223/484 (46%)
		Voltage_CLC	227..615	CDD:279048	182/396 (46%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	32/95 (34%)
clh-2	NP_001364585.1	ClC_1_like	86..567	CDD:239655	223/484 (46%)
clh-2	NP_001364585.1	CBS_pair_SF	580..809	CDD:417695	94/434 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3158
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14197
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880