DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and clh-5

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_495940.1 Gene:clh-5 / 174449 WormBaseID:WBGene00000532 Length:797 Species:Caenorhabditis elegans


Alignment Length:738 Identity:202/738 - (27%)
Similarity:332/738 - (44%) Gaps:165/738 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 ARDSDSSDDDDPIGYIDTLMYGRYTKDL------------GEF-----AKDEARKLKILEKRRKQ 136
            |....||.|.:|.|.||.:.: :...||            |:|     .:|.||           
 Worm    33 AGGGSSSSDFNPFGAIDDVRF-KTDDDLPDVMAPPFFSKYGDFHTIDWQRDLAR----------- 85

  Fly   137 EDKQRNKELLGKHSTRAKRV--------SSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKG- 192
             |:.|:| ::.|     |:|        |.|       ..|..|:.:..:|:.....:.|:|.| 
 Worm    86 -DRLRHK-MISK-----KKVDFPLGLLQSGW-------DAGAGWICVLFVGLAAGATAGIIDIGA 136

  Fly   193 -------ISICTNARIWL-------------YRD-----LTSQP--------------FVQYIAW 218
                   ..:|.: |.||             |:|     .|..|              |:::|.:
 Worm   137 RWMSDLKTGVCAD-RFWLDHEHCCWSSNDTFYKDDDCKAWTKWPWMLNYYNSSSFLFLFLEWIFY 200

  Fly   219 VSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPL 283
            :...|.:...:..||.:.||.:.||||||:|.||.|..::.||...|.:.|.:||..:..||:.|
 Worm   201 IGWAVAMSTLAVLFVKIFAPYACGSGIPEIKCILSGFVIRGYLGKWTFIIKSVGLILSSASGLSL 265

  Fly   284 GKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTT 348
            |||||.||:|..:..:.|.|...: |:  ||::..|:|:|:.|.||...|.||:||||||:|..:
 Worm   266 GKEGPMVHLACCIGNIFSYLFPKY-GL--NEAKKREILSASAAAGVSVAFGAPIGGVLFSLEEAS 327

  Fly   349 TYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCG 413
            .||.::..||.||.|:....:.|.:..:..|.   .:||..::..::.|  .||..||::||..|
 Worm   328 YYFPLKTMWRSFFCALVAGIILRFVNPFGSNQ---TSLFHVDYMMKWTF--IELVPFAILGLFGG 387

  Fly   414 LGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISF--PLGTGQFLAGELSTHE 476
            :.|:.:::.:.|:..| |.|.:|   |..|.......:.|:.::||:  |.       ...|...
 Worm   388 IIGSLFIFANIRWSRF-RKNSKM---LGGNPIYEVMLITLVTAAISYFNPF-------TRKSAQS 441

  Fly   477 QVTQLFSNF--TWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFI 539
            .:.|||...  ....|.|..:..|:        :..||.|:...:|.||::|....|.||.|:|:
 Worm   442 MIQQLFDRCEDQIDEDSLCDQNKAL--------SIAFGQLLWALIFKFVITIFTFGIKVPCGLFV 498

  Fly   540 PVFKIGAGFGRLVG-----EFMAV--TFPHGVRYGGRLSP--IMPGGYAVVGAAAFSGSVTH-TV 594
            |...:||..||::|     .|.||  |..|...:..::..  :|||.||:|||||..|.||. ||
 Worm   499 PSIGMGAIAGRILGITVDQIFRAVQATPGHSDYFTCQIGKDCVMPGLYAMVGAAAVLGGVTRMTV 563

  Fly   595 SVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKKLPYLPDLLPSSSGMY--- 655
            |:.||:||:||.:..:||.|:|.:.:..:. .:.:..||::.|.:...|:|     .|.|.|   
 Worm   564 SLVVIMFELTGSLEFIVPTMVATMFSKWIGDGISKMGIYEAHIELNGYPFL-----DSKGEYPYS 623

  Fly   656 ---------SI---FVEDFMVRDVKYIWH--------GISYQKLKEVLKLNKTLRSLPLVDSPDN 700
                     ||   ..::..:.|::.:.:        |::...|:.:|: .......|:|.|.::
 Worm   624 TVASQVMRPSIHRQVADEMSMSDLRELKNELSVITESGMTLGDLESLLR-QTDFNGFPVVVSQNS 687

  Fly   701 MILLGSVQRYELIKMIEKHIGRE 723
            |.|:|.:.|.::  ::..|..|:
 Worm   688 MHLVGFITRRDI--LLALHTARK 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 160/529 (30%)
Voltage_CLC 227..615 CDD:279048 137/401 (34%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964
clh-5NP_495940.1 ClC_3_like 122..614 CDD:239656 158/519 (30%)
Voltage_CLC 206..594 CDD:279048 139/414 (34%)
CBS 650..788 CDD:223591 12/62 (19%)
CBS_pair_EriC_assoc_euk_bac 653..790 CDD:239964 12/59 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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