Protein Alignment ClC-a and clh-3

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001300535.1
• Gene: clh-3 / 174187
• WormBaseID: WBGene00000530
• Length: 1091
• Species: Caenorhabditis elegans
• Alignment Length: 1212
• Identity: 434/1212 - (35%)
• Similarity: 610/1212 - (50%)
• Gaps: 265/1212 - (21%)

  Fly    73 KIKSHAFYPCPPPAENARDSDSSDDDD------PIGYIDTLMYGRYTKDLGEFAK------DEAR 125
            ||:..:..|. ||.::.:|:...::::      |.|....|..|.:   ||.:..      ||..
 Worm     9 KIEWQSLLPL-PPEKSEKDATIENNEELEKIRMPAGKEYDLQPGSH---LGVYKTVRGLPIDEDS 69

  Fly   126 K-----LKILEKRRKQEDKQRNKELLGKHSTRAKRVSSW-------IWRHTVARLGEDWVFLALL 178
            |     .|||.|..|  :|..:...:....|..|:.|||       .:..||.|   ||:|||||
 Worm    70 KSMGIGTKILSKIEK--NKTSDGLTIPLTPTTQKQSSSWCSFESIKTFFRTVIR---DWIFLALL 129

  Fly   179 GIIMALLSFIMDKGISICTNARIWLYRDLTSQPF--VQYIAWVSLPVCLILFSAGFVHLIAPQSI 241
            |.|||.|||.||..|....|.::.|: ||..:..  :.|:.||...|.|||.||...|.||||:|
 Worm   130 GFIMASLSFGMDYAILNLQNGQMRLF-DLVKEYHFTLAYLVWVGYVVGLILLSAVCAHYIAPQAI 193

  Fly   242 GSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLV-T 305
            ||||||||||||||.|||||:.:||::|:||||.:||||:|:||||||||:||:||..|::|| .
 Worm   194 GSGIPEMKTILRGVILKEYLSVRTLLSKMIGLTLSLGSGLPMGKEGPFVHVASVVASQLTRLVHG 258

  Fly   306 SFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVF 370
            |..||:|||||:.|||||.|||||...|:||:||||||||||:.||||||||||||||.|.||:|
 Worm   259 SSGGIFENESRSGEMLAAGCAVGVACTFSAPIGGVLFSIEVTSVYFAVRNYWRGFFAATCSATLF 323

  Fly   371 RLLAVWFQNAD-TVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNK 434
            |:|.::..:|. ||.|.:.|||..:..|.||||.:||||||||||.|:.:|::|||.|||:|.|.
 Worm   324 RILRMFSVSAAVTVEAHYQTNFPPQNVFLPQELPIFALIGLVCGLAGSIFVYLHRRTVLFLRRNW 388

  Fly   435 RMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTH---EQVTQLFSNFTWS-------- 488
            ......||...:||.|:|..:||:|||||.|:|:.||:...   ..:.:.|.:..|:
 Worm   389 LAKMIFQKYWLIYPIFIATFISSLSFPLGLGKFMGGEIFQERFSHTMKEFFVDCAWTAPPNDSYA 453

  Fly   489 ----RDDLTVEQAAVVTHWM-TSYT-SVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAG 547
                ..:.|...:..:.||. .:|. |.|..|..:.:..|.::|:|||:|||||:|:|||.:||.
 Worm   454 CPMPTSNATSSDSFDIRHWKGDNYDYSPFVTLSSFQVVYFFLAILASTLPVPSGIFMPVFVLGAA 518

  Fly   548 FGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVP 612
            |||||||.:....|:|...|.....:.||.|||||||||.|:||||||||||:||:|||:.|::|
 Worm   519 FGRLVGEGVFSLDPYGHISGDIQFFVRPGVYAVVGAAAFCGAVTHTVSVAVIVFELTGQLCHLLP 583

  Fly   613 VMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQ 677
            ||||||:|||||:.||||||||||.||.||||||:..::|..:.:.:|.||:..:.||....:..
 Worm   584 VMIAVLIANAVASYLQPSIYDSIIRIKNLPYLPDIPHTTSLYHQMLIEQFMISPLVYIAKDSTVG 648

  Fly   678 KLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRM-----EVAQKWQKEAQ 737
            .:|..|:....:|:.|||::.:::.|:|||.|.:|.:.::..||.:.|.     .:.|:.:.|..
 Worm   649 DIKRALETKTRIRAFPLVENMESLALVGSVSRSQLQRYVDSQIGTKARFAEATRRIKQRLEDEES 713

  Fly   738 ERALEEEKKKQEVELKM-------RRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAP 795
            ||...||.|..:.|..:       ||.|||.::|...
 Worm   714 ERKRREESKSDDTEDSLETTGAGERRASRFLIVPVAK---------------------------- 750

  Fly   796 RKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGS 860
                                 :.|.:....|:||.||...|        |..|:::.|      :
 Worm   751 ---------------------NGPQVAKNETLTGLSEENAR--------KILTVEEKQ------A 780

  Fly   861 LSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKAL 925
            |..|||         .:||    |.::..::            :||:..||:
 Worm   781 LFDAAS---------LATP----KREMSGKT------------INPVHIESH------------- 807

  Fly   926 SNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSI 990
            ...||..:....:.|........|..             ||..:.|...:.            ||
 Worm   808 HTIGDIFRSITHLSFGRQNFPKKNNH-------------NEFDLFGEENQK------------SI 847

  Fly   991 EDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQL 1055
            .|     :|:.:                      |::.:|  |:|:....|..:.:.||.:||||
 Worm   848 ND-----DPDFI----------------------ENRTEW--EDMMLNQKLDLSQLDIDSTPFQL 883

  Fly  1056 VERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNS--------FVPPTRDE 1112
            .|.||:.|.|||||::|:|.|||||.|:|:|||.|||||.|||.:.|..        |..|..::
 Worm   884 SEYTSLFKAHSLFSLLGLNRAYVTKKGQLIGVVALKELRLAIEYLQSGKVPTPGMSIFNEPPTEQ 948

  Fly  1113 DADEKPAVEKPLLSTNSSDKAVDMTVTSMDSALSN---------------SENCSDI-EMEHIKH 1161
            ...||.|..:...:|..:..|..:|....|.|.::               ....|:: .:|:::.
 Worm   949 SIYEKSARLESGRATGDAQNAAFVTDNGEDDAQNDYIQPPLEVVRRGALTPNRMSELTRLENVRT 1013

  Fly  1162 TDKGTVSLTMPPQESKQSPSA------------DKSNTENGN 1191
            |.:.       |.....|||.            |.:|:|||:
 Worm  1014 TPES-------PHFEVSSPSTSSSCVSIDFSPLDAANSENGS 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	273/495 (55%)
		CBS_pair_SF	659..>718	CDD:449531	17/58 (29%)
		CBS repeat	664..715	CDD:341358	14/50 (28%)
		CBS_pair_SF	<1032..1096	CDD:449531	35/63 (56%)
		CBS repeat	1053..1095	CDD:341358	28/41 (68%)
clh-3	NP_001300535.1	ClC_1_like	122..617	CDD:239655	273/495 (55%)
		CBS_pair_SF	629..>684	CDD:449531	16/54 (30%)
		CBS repeat	635..684	CDD:341358	13/48 (27%)
		CBS_pair_SF	<870..924	CDD:449531	32/53 (60%)
		CBS repeat	881..923	CDD:341358	28/41 (68%)