DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-a and Clcnka

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001139779.1	Gene:	Clcnka / 12733	MGIID:	1329026	Length:	687	Species:	Mus musculus

Alignment Length:	667	Identity:	256/667 - (38%)
Similarity:	394/667 - (59%)	Gaps:	46/667 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.|..|||.||..||::|||:|:.|:..|.....|..||||::.....::|::|...||
Mouse    38 WL-KERLFRAREDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.|||:||:||:|.||.|:.||..|...|||:||:.||  ||.:.|||.
Mouse   102 ALLSFSSGFSQSITPFSGGSGLPELKTMLSGVVLENYLDIKNFGAKVVGLSCTLATGSTIFLGKV 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.:::..|.::.....|..|::::..|||:||.||||...||||..||||||||.:::|
Mouse   167 GPFVHLSVMISAYLGRVRAKAVGDTESKAKEVEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.|||||||||.|||.:||||||:....:|:.:::.|.|..:.|||..|:|.|..:|.:||:..
Mouse   232 SVWNYWRGFFAATCGAFMFRLLAVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGILS 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ..|::..|.::.|:::|:..:|.|..::..|...:||:::|:::|.|.|:|:|..||..|.:..|
Mouse   297 CVYLFCQRNFLRFIKTNRYTSKLLATSKPSYAALVALVLASVTYPPGVGRFMASRLSMAEHLHSL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |....|:           :...|.....::||.|..:.:..|.:.|:|:|||:|:
Mouse   362 FDNNSWA---LMTRNASPPWPSEPDPQNLWFEWYHPRFTIFGTLAFFLIMKFWMLILATTIPMPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|.|||..|||:||.::|.||.|:..||.:.||||||||:.|||||||:||||:|.|::.
Mouse   424 GYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGGEVYPIMPGGYALAGAAAFSGAVTHTISTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVR 665
            ||:||||.|.:||::|||.||.::..||||.||..|:.|||||||.:.....|.|.:.||.||..
Mouse   489 FELTGQIVHALPVLMAVLAANVISQNLQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNS 553

  Fly   666 DVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEV 728
            ::..:   .....|:||:|:  :..:...|||::.::..|:|.|:|..|::.::..
Mouse   554 NLTTL---AKDMPLEEVVKVVTSTDVSQYPLVETRESQTLVGIVERTHLVQALQTQ--------- 606

  Fly   729 AQKWQKEAQERALEE----EKKKQEVELKMR-RPSRFEVLPAPDILSL---------RQIANDEM 779
            ...| ...|||.|::    ....|.|.|::. ..|.::.....::|:|         |.:.:...
Mouse   607 PASW-APGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHRLFELLTLQALFVTSRGRAVGSVSW 670

  Fly   780 LPPKKRAETMHGSLAPR 796
            :..||...|:....||:
Mouse   671 VELKKAISTLINPPAPK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	217/487 (45%)
		Voltage_CLC	227..615	CDD:279048	177/400 (44%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcnka	NP_001139779.1	ClC_1_like	49..533	CDD:239655	216/486 (44%)
		Voltage_CLC	106..514	CDD:279048	182/410 (44%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	25/133 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810