DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-a and Clcn5

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_011245744.1	Gene:	Clcn5 / 12728	MGIID:	99486	Length:	851	Species:	Mus musculus

Alignment Length:	763	Identity:	223/763 - (29%)
Similarity:	337/763 - (44%)	Gaps:	193/763 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SDSSDDD--------------DPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK---------- 132
            |.|||:|              |.:..:|..:.|..:.:.|...... |.:..||:
Mouse    58 SSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSN-RVMDFLEEPIPGVGTYDD 121

  Fly   133 -------RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
                   |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|
Mouse   122 FNTIDWVREKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLID 181

  Fly   191 KGIS----------ICTNARIWL---------------YRDL-------------TSQ------- 210
              ||          |||.. .|.               :||.             |.|
Mouse   182 --ISAHWMTDLKEGICTGG-FWFNHEHCCWNSEHVTFEHRDKCPEWNSWAQLIINTDQGAFAYIV 243

  Fly   211 PFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTA 275
            .:..|:.|..|   ....:...|...||.:.||||||:||||.|..::.||...|||.|.|.|..
Mouse   244 NYFMYVLWALL---FAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVL 305

  Fly   276 TLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGV 340
            .:.||:.||||||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:|||
Mouse   306 AVSSGLSLGKEGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGV 367

  Fly   341 LFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVF 405
            |||:|..:.||.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|
Mouse   368 LFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPF 427

  Fly   406 ALIGLVCGLGGASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFP 461
            .::|:..||.||          ||:|:|     ||....|.|    ||....|:|::|    :||
Mouse   428 IVLGIFGGLWGA----------LFIRTNIAWCRKRKTTQLGK----YPVVEVLIVTAITAILAFP 478

  Fly   462 LGTGQFLAGELSTHEQVTQLF---------------SNFTWSRDDLTVEQAAVV----THWMTSY 507
               .::.  .:||.|.:::||               ::|..|:.....::.|.|    ..|..:.
Mouse   479 ---NEYT--RMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGIYSAMWQLAL 538

  Fly   508 TSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFM-AVTFPH---GVRYGG 568
            |.:.  .::.|:|||.:.|       |||:|||...:||..|||:|..| .:.:.|   |: :..
Mouse   539 TLIL--KIVITIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGI-FNS 593

  Fly   569 RLSP----IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALL 627
            ..|.    |.||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.
Mouse   594 WCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALG 658

  Fly   628 QPSIYDSIILIKKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQ 677
            :..|||:.|.:...|:|.            |::.  .:..:.::..:|.| |.||
Mouse   659 REGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV---------- 713

  Fly   678 KLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725
               |.:....|....|:|.|.::..|:|.|.|.:||..||.  .|:|:
Mouse   714 ---ETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	180/569 (32%)
		Voltage_CLC	227..615	CDD:279048	150/424 (35%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
Clcn5	XP_011245744.1	ClC_3_like	177..675	CDD:239656	175/540 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	686..836	CDD:341367	21/86 (24%)
		CBS repeat	692..787	CDD:341367	20/80 (25%)
		CBS repeat	793..835	CDD:341367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810