DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and Clcn4

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001344031.1 Gene:Clcn4 / 12727 MGIID:104571 Length:747 Species:Mus musculus


Alignment Length:742 Identity:212/742 - (28%)
Similarity:323/742 - (43%) Gaps:178/742 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI---- 193
            |.|..|..|::::..|     .:.|.|.:..::......||.:.|:|::...|:.::|..:    
Mouse    24 REKSRDTDRHRKITSK-----SKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMT 83

  Fly   194 ----SICTNARIWLYRD--------------------------LTSQP---------FVQYIAWV 219
                .:|.:| .|...:                          |.||.         ::.||.|.
Mouse    84 DLKEGVCLSA-FWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWA 147

  Fly   220 SLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLG 284
            .|   ....:...|.:.||.:.||||||:||||.|..::.||...||:.|.:.|...:.||:.||
Mouse   148 LL---FAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLG 209

  Fly   285 KEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTT 349
            ||||.||:|.......|.|.:.:.   :||.:..|:|:||.|.||...|.||:||||||:|..:.
Mouse   210 KEGPLVHVACCCGNFFSSLFSKYS---KNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSY 271

  Fly   350 YFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGL 414
            ||.::..||.||||:..|...|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||
Mouse   272 YFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEYHT--PWYMAELFPFILLGVFGGL 331

  Fly   415 GGASY-----VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLG-----TGQFLA 469
            .|..:     .|..|      |...|:.:        ||....:.|::::..:.     |.|   
Mouse   332 WGTLFTRCNIAWCRR------RKTTRLGR--------YPVLEVIAVTAVTAIVAYPNPYTRQ--- 379

  Fly   470 GELSTHEQVTQLFS-----------------NFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
               ||.|.:::||:                 |.|...||:....|.|..     ||::: .|.:.
Mouse   380 ---STSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGV-----YTAMW-QLALA 435

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPI 573
            .:|..|::|....:.:|||:|||...:||..||:||   |.:|      :.|.:..|.|.  ..:
Mouse   436 LIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGA--DCV 498

  Fly   574 MPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSII 636
            .||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| |..:..||::.|
Mouse   499 TPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHI 563

  Fly   637 LIKKLPYL------------PDLLPSSSG--MYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLN 686
            .:...|:|            .|::....|  ..|:..:|.| |.||:.:        :||.    
Mouse   564 HLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETL--------IKET---- 616

  Fly   687 KTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVE 751
             .....|::.|.|:..|:|..||.|||..|                 |.|::|  :|......:.
Mouse   617 -DYNGFPVLVSRDSERLIGFAQRRELILAI-----------------KNARQR--QEGIVSNSIM 661

  Fly   752 LKMRRPSRFEVLPA--PDILSLRQIAN 776
            .....|..   |||  |..|.||:|.|
Mouse   662 YFTEEPPE---LPANSPHPLKLRRILN 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 170/567 (30%)
Voltage_CLC 227..615 CDD:279048 144/424 (34%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964
Clcn4NP_001344031.1 Required for localization in the endoplasmic reticulum. /evidence=ECO:0000250|UniProtKB:P51793 1..50 7/30 (23%)
ClC_3_like 65..571 CDD:239656 166/545 (30%)
Selectivity filter part_1. /evidence=ECO:0000250 167..171 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 209..213 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 454..458 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 582..732 CDD:341367 35/139 (25%)
CBS repeat 588..683 CDD:341367 32/129 (25%)
Required for localization in the endoplasmic reticulum. /evidence=ECO:0000250|UniProtKB:P51793 654..683 8/31 (26%)
CBS repeat 689..731 CDD:341367
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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