DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and Clcn1

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_038519.1	Gene:	Clcn1 / 12723	MGIID:	88417	Length:	994	Species:	Mus musculus

Alignment Length:	1106	Identity:	413/1106 - (37%)
Similarity:	584/1106 - (52%)	Gaps:	239/1106 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QRH----------PKIKSHAFYPCPP---PAENA-------RDSDSSDDDDPIGYIDTLMYGRYT 113
            |||          |:.:...|..|..   |:||.       :|.....:..|     |.:||...
Mouse     7 QRHGGEQSWWGSAPQYQYMPFEHCTSYGLPSENGGLQHRPRKDMGPRHNAHP-----TQIYGHQK 66

  Fly   114 KDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALL 178
            :.....|:|....       :|.........|...|.::.:.....:.|....:|||||:||.||
Mouse    67 EQYSYKAQDGGMP-------KKMGSSSTMDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLL 124

  Fly   179 GIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGS 243
            |::|||:|:.||...:....|..|.|..:.....:||:|||:.|:.||||||.|..||:||::||
Mouse   125 GLLMALVSWCMDYVSAKSLQAYKWTYAQMKPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGS 189

  Fly   244 GIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQ 308
            ||||||||||||.||||||.|..||||:.|||.||||:|:||||||||||||.|.:|||.::.|.
Mouse   190 GIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFS 254

  Fly   309 GIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLL 373
            |:||.....:::|...||||||.||..|:||||||||||:|||||||||||||||...|.|||:|
Mouse   255 GVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVL 319

  Fly   374 AVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNK 438
            |||.::|.|:.|||.|||..:||||.:||..||:||:.||..||.:|::||:.:|.:|.:|.:::
Mouse   320 AVWNKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKCLSQ 384

  Fly   439 FLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR---DDLTVEQAAVV 500
            ||.|:|.||||.:..:::|::||.|.|||:||||...|.::.||.|.||.:   |..::.|:||
Mouse   385 FLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPQSLGQSAV- 448

  Fly   501 THWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVR 565
              |:....:|...::::.:..|.:||:|:|:|:|.|.|:|||.:||.|||||||.||:.||.|:.
Mouse   449 --WLHPQVNVIIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGIL 511

  Fly   566 YGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPS 630
            :...:..|:||||||:||||.:|:|:||||.|||.||:||||.|::|:|:||::||.||..||||
Mouse   512 FDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPS 576

  Fly   631 IYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLV 695
            :|||||.:|||||||||..:....::|||||.||||||::....:|.:|:.:|:.. |:::||||
Mouse   577 LYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELRNLLQAT-TVKTLPLV 640

  Fly   696 DSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRF 760
            ||.|:|||||||:|.||..::::|:..|:|::.||...::..|
Mouse   641 DSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLSE---------------------- 683

  Fly   761 EVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYT 825
                               ||...:|: :.|...|                    |..|
Mouse   684 -------------------LPYNGKAQ-LAGDWHP--------------------GGRP------ 702

  Fly   826 TITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQ 890
                               :|....|...|.:.        :.::|:|.||:.|..|..   |..
Mouse   703 -------------------ESFAFVDEDEDEDL--------SRKMELPLTPAPPPPSPP---PPP 737

  Fly   891 SNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNG--DSSKQSPSIKFKANKVADVNRSP- 952
            |.:            ||:..:.:.|            ||  .|.||.|    :|:..||...|.
Mouse   738 SQF------------PIAPSNPEEP------------NGPLPSHKQPP----EASDSADQRSSTF 774

  Fly   953 QTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRE 1017
            |....|                                          .|.::..|.|.:.....
Mouse   775 QRLLHC------------------------------------------LLGKAHSKKKKITQDST 797

  Fly  1018 RVID-MSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKI 1081
            .::| ||||:.:.||.|::.:|:.....  .||.|||||||:|::.|.|:|||::|::.||||.:
Mouse   798 DLVDNMSPEEIEAWEREQLSQPVCFDCC--CIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSM 860

  Fly  1082 GRLVGVVGLKELRKAIED---------------INSNSF------VPPTRD-----EDADEKPAV 1120
            |:|.||:.|:||:||||.               .|:.|.      .||..:     ||.|..|..
Mouse   861 GKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSIRKTPGGPPPPAEGWNVPEDGDGAPGR 925

  Fly  1121 E 1121
            |
Mouse   926 E 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	264/477 (55%)
		Voltage_CLC	227..615	CDD:279048	218/390 (56%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	39/96 (41%)
Clcn1	NP_038519.1	ClC_1_like	117..592	CDD:239655	264/477 (55%)
		Voltage_CLC	170..571	CDD:279048	226/403 (56%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair	610..>665	CDD:301603	26/55 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..770		21/98 (21%)
		CBS_pair_EriC_assoc_euk_bac	<827..875	CDD:239964	27/47 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..954		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	495	1.000	Domainoid score	I361
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	767	1.000	Inparanoid score	I539
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D194160at33208
OrthoFinder	1	1.000	-	-		FOG0002718
OrthoInspector	1	1.000	-	-		otm44235
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4171
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910