Protein Alignment ClC-a and CLCNKB

DIOPT Version :9

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_000076.2
• Gene: CLCNKB / 1188
• HGNCID: 2027
• Length: 687
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 246/574 - (42%)
• Similarity: 370/574 - (64%)
• Gaps: 22/574 - (3%)

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.||||||.||..||::|||:|..||..:.....|..||||::.....::|::|...||
Human    38 WL-KQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.||||||:||:|.||.|::||..|...|||:||:.||  ||.:.|||.
Human   102 ALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKV 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.::|..|.::.|:..|..||:|:.:|||.||.||||...||||..||||||||.:::|
Human   167 GPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.:||||||||.|||.:||||||:....:|:.:|:.|:|..:.|||..|:|.|..:|.:||:.|
Human   232 SVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILG 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ::|::..|.:..|:|:|:..:|.|..::.:|.....|:::||::|...|:|||..||..:.:..|
Human   297 SAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |..:.::           :...|.....::||.|..:.:..|.:.|:|:|||:|:
Human   362 FDNHSWA---LMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|..||..|||.||.::..||.|:..||..:||||||||:.|||||||:||||:|.|::.
Human   424 GYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVR 665
            ||:||||.|.:||::|||.|||:|...|||.||..:::|||||||.:|..:.|.:.:.||.||..
Human   489 FEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNH 553

  Fly   666 DVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQRYELIKMIE 717
            .:..:   .....|:||:|:  :..:...|||:|.::.||:|.|:|.:|::.::
Human   554 SITTL---AKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALK 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	220/487 (45%)
		Voltage_CLC	227..615	CDD:279048	180/400 (45%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
CLCNKB	NP_000076.2	ClC_1_like	49..534	CDD:239655	220/487 (45%)
		Voltage_CLC	106..513	CDD:279048	186/409 (45%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	14/53 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810