DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and CLCN7

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001278.1 Gene:CLCN7 / 1186 HGNCID:2025 Length:805 Species:Homo sapiens


Alignment Length:792 Identity:200/792 - (25%)
Similarity:336/792 - (42%) Gaps:174/792 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 FAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE--DWVFLALLGII 181
            |.|:.....|:|..:.:..|...::..|.....|  |::     ||..|..|  .||..||:||:
Human    79 FPKEIPHNEKLLSLKYESLDYDNSENQLFLEEER--RIN-----HTAFRTVEIKRWVICALIGIL 136

  Fly   182 MALLSFIMDKGISICTNARIWLYRDLTS--QPFVQ-------YIAWVSLPVCLILFSAGFVHLIA 237
            ..|::..:|   .:..|.....||.:..  ..|.:       .:.|.:|....:|..:..|..|.
Human   137 TGLVACFID---IVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIE 198

  Fly   238 PQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSK 302
            |.:.|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..|::|..:|:
Human   199 PVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQ 263

  Fly   303 -----LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRG 359
                 |...|: |:|...|::|   .::|..|.||.|.|.|||||||||:|...:::.....||.
Human   264 GRSTSLKRDFK-IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRI 327

  Fly   360 FFAAVCGA-TVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLVCGLGGASY 419
            |||::... |:..:|:::..|...:.:..|.||    :.:..:...|:.||..:|:|.|:.||  
Human   328 FFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA-- 390

  Fly   420 VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFL----ALLVS-----------------------S 457
                    :|...|..:..|  :.|:::...|    |:||:                       |
Human   391 --------VFNALNYWLTMF--RIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445

  Fly   458 ISFPL----GTGQF---LAGELSTHEQ-VTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNL 514
            :|:||    ..|::   .|...:|.|: |..||.:...|.:.||                    |
Human   446 MSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLT--------------------L 490

  Fly   515 VIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYA 579
            .::||..|.::.....:.|.:|:|||...|||.:|||.|  :::::..|......     ||.||
Human   491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG--ISLSYLTGAAIWAD-----PGKYA 548

  Fly   580 VVGAAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPY 643
            ::|||| ..|.|..|:|:.||:.|.|..:|:..|:|:.::.|..|..:....:||..|.::.:|:
Human   549 LMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPF 613

  Fly   644 LPDLLPSSSGMYSIFVEDFMVRDVKYIWH----GISYQKLKEVLKLNKTLRSLPLVDSPDN---M 701
            |....|.:|  :|:...:.|...|..:..    |:....|.:....:   ...|:|:..|:   .
Human   614 LHWEAPVTS--HSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNH---NGFPVVEHADDTQPA 673

  Fly   702 ILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPA- 765
            .|.|.:.|.:||.:: ||                   :...|......|:.::|.....:..|. 
Human   674 RLQGLILRSQLIVLL-KH-------------------KVFVERSNLGLVQRRLRLKDFRDAYPRF 718

  Fly   766 PDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGN 830
            |.|.|: .::.||      |..||                 :|..:..|       :|||.....
Human   719 PPIQSI-HVSQDE------RECTM-----------------DLSEFMNP-------SPYTVPQEA 752

  Fly   831 SEFRIRSAFEAI 842
            |..|:...|.|:
Human   753 SLPRVFKLFRAL 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 150/532 (28%)
Voltage_CLC 227..615 CDD:279048 128/436 (29%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964
CLCN7NP_001278.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
ClC_6_like 95..620 CDD:239657 158/574 (28%)
Selectivity filter part_1. /evidence=ECO:0000250 203..207 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 245..249 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 512..516 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 626..790 CDD:341367 35/193 (18%)
CBS repeat 632..740 CDD:341367 26/154 (17%)
CBS repeat 746..789 CDD:341367 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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