DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and CLCN5

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_016884746.1	Gene:	CLCN5 / 1184	HGNCID:	2023	Length:	820	Species:	Homo sapiens

Alignment Length:	687	Identity:	207/687 - (30%)
Similarity:	314/687 - (45%)	Gaps:	153/687 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD------- 190
            |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|
Human    98 REKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMT 157

  Fly   191 ---KGI----------SICTNARIWLYRDLTSQP----------------------FVQYIAWVS 220
               :||          ..|.|:....:.:....|                      :..|:.|..
Human   158 DLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWAL 222

  Fly   221 LPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGK 285
            |   ....:...|.:.||.:.||||||:||||.|..::.||...|||.|.|.|...:.||:.|||
Human   223 L---FAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGK 284

  Fly   286 EGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTY 350
            |||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:||||||:|..:.|
Human   285 EGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYY 346

  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415
            |.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|.|:|:..||.
Human   347 FPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPFILLGIFGGLW 406

  Fly   416 GASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQFLAGE 471
            ||          ||:|:|     ||....|.|    ||....|:|::|    :||   .::.  .
Human   407 GA----------LFIRTNIAWCRKRKTTQLGK----YPVIEVLVVTAITAILAFP---NEYT--R 452

  Fly   472 LSTHEQVTQLFSN---------------FTWSR-DDLTVEQAAVVTH---WMTSYTSVFGNLVIY 517
            :||.|.:::||::               |..|: .:|....|.|..:   |..:.|.:.  .::.
Human   453 MSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLIL--KIVI 515

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP----IMP 575
            |:|||.:.|       |||:|||...:||..|||:|   |.:|........:....|.    |.|
Human   516 TIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITP 573

  Fly   576 GGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILI 638
            |.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..|||:.|.:
Human   574 GLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRL 638

  Fly   639 KKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKT 688
            ...|:|.            |::.  .:..:.::..:|.| |.||             |.:....|
Human   639 NGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV-------------ETIISETT 690

  Fly   689 LRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725
            ....|:|.|.::..|:|.|.|.:||..||.  .|:|:
Human   691 YSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	176/565 (31%)
		Voltage_CLC	227..615	CDD:279048	151/423 (36%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964
CLCN5	XP_016884746.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810