DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and clcn2

DIOPT Version :9

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:XP_002935192.2 Gene:clcn2 / 100488889 XenbaseID:XB-GENE-494657 Length:882 Species:Xenopus tropicalis


Alignment Length:1089 Identity:444/1089 - (40%)
Similarity:608/1089 - (55%) Gaps:226/1089 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKR-----VSSWIWR 162
            |..||||||||:|||.|||:||.:::...:..:...|.:..||.....:|..:     |.|  .|
 Frog    13 YEQTLMYGRYTQDLGVFAKEEAARIRQEREVHRPATKPQTVELREYDESRCAKCKICCVHS--QR 75

  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL 227
            ..::|:||||:||.|||::|||:|:.||..|:||..|..|:|..|.:..|:||:|||:.||.||.
 Frog    76 LVLSRVGEDWIFLILLGLLMALVSWAMDFTIAICLQAHKWMYGGLDNNVFLQYLAWVTYPVVLIT 140

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            |||||..::|||::||||||||||||||.||||||.||.:|||||||..||||:||||||||||:
 Frog   141 FSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGLPLGKEGPFVHV 205

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            ||:.|.|||||::.|.|||||||||.||||||||||||.|||||:||||||||||:|:|||||||
 Frog   206 ASMCAALLSKLMSLFGGIYENESRNIEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW 270

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ||||||...|.:||:||||.::.:|:.|||.|:|..:||||.|||..||:||:..|.|||.:|::
 Frog   271 RGFFAATFSAFIFRVLAVWIKDEETITALFKTSFRLDFPFDLQELPAFAVIGIASGFGGALFVYL 335

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTW 487
            :|:.|.|||..|.:|:||.|.|.|:|..:.|||::::||.|.|||:||:|:..|.:..||.|:||
 Frog   336 NRKIVEFMRKQKTINRFLMKKRLLFPALVTLLVATLTFPPGFGQFMAGQLTQKETLVTLFDNYTW 400

  Fly   488 SRDDLTVEQA--AVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGR 550
            ::..::.:.|  .:.:.|.....:||..||::.|..|.:|.:|:|||||.|.|:|||.|||.|||
 Frog   401 AQQGISEDFAYRGISSVWKHPKANVFVTLVVFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGR 465

  Fly   551 LVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMI 615
            ||||.||..||.|:...|....|:|||||||||||.||:||||||.|||:||:||||:|::||||
 Frog   466 LVGESMAAWFPDGIHTDGSTYRIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTGQISHILPVMI 530

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLK 680
            ||::|||||..||||:|||||.||||||||:|.......|::.|||.|:|::.::.....|:.|:
 Frog   531 AVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGHQEKYNVRVEDIMLRNIPFVTLNSKYRDLQ 595

  Fly   681 EVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEK 745
            |:| .|..|:.|.||::.::||||||:.|.:|:.::...:..::|::         |.|..|...
 Frog   596 ELL-TNCHLKCLALVETAESMILLGSIDRSQLLSLLRFQLSSKRRLQ---------QLRERESSG 650

  Fly   746 KKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKT 810
            |||     .....||::.......|          ||  :.||.    .|.|..||.|.|     
 Frog   651 KKQ-----TENSVRFQITTEESTFS----------PP--QGETR----KPLKPALKHTLS----- 689

  Fly   811 YAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRT 875
               .:..||:.....::|         |.::||    ..:|.              :..:||.:.
 Frog   690 ---SLTESPADDSDNSVT---------ALKSIF----CAKDF--------------SEPLEVVKD 724

  Fly   876 PSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKF 940
            |::|  |||                                                        
 Frog   725 PASP--SKK-------------------------------------------------------- 731

  Fly   941 KANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAES 1005
                                               .|.::|..:.||..::::|..|..:.|   
 Frog   732 -----------------------------------NKSRLKHRHRLGEDLDEIDTMTQSQIL--- 758

  Fly  1006 IQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSM 1070
                                   :||..::.:||:|.  |..|||:|||||||||:.|.|::||:
 Frog   759 -----------------------EWEEIQLEEPINLN--NCKIDPAPFQLVERTSLHKAHTVFSL 798

  Fly  1071 VGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSDKAVD 1135
            :|::|||||.||||:|:|.|:|||||||.             ....|.|..:|.|::..     |
 Frog   799 LGMDHAYVTSIGRLIGMVTLRELRKAIEG-------------SVTVKGAKLRPPLASFR-----D 845

  Fly  1136 MTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184
            ...:|.|:..:|.....:....|:.            |:||..|.|.||
 Frog   846 SVTSSSDTETTNVNKLWERSRRHLL------------PRESSPSDSDDK 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 293/476 (62%)
Voltage_CLC 227..615 CDD:279048 238/389 (61%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964 39/95 (41%)
clcn2XP_002935192.2 ClC_1_like 84..561 CDD:239655 293/476 (62%)
CBS_pair_voltage-gated_CLC_euk_bac <774..824 CDD:341367 32/49 (65%)
CBS repeat 781..823 CDD:341367 27/41 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 504 1.000 Domainoid score I340
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3213
Inparanoid 1 1.050 769 1.000 Inparanoid score I535
OMA 1 1.010 - - QHG52624
OrthoDB 1 1.010 - - D1131873at2759
OrthoFinder 1 1.000 - - FOG0002718
OrthoInspector 1 1.000 - - otm49410
Panther 1 1.100 - - LDO PTHR45720
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4171
SonicParanoid 1 1.000 - - X544
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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