Protein Alignment ClC-a and clcn2

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_002935192.2
• Gene: clcn2 / 100488889
• XenbaseID: XB-GENE-494657
• Length: 882
• Species: Xenopus tropicalis
• Alignment Length: 1089
• Identity: 444/1089 - (40%)
• Similarity: 608/1089 - (55%)
• Gaps: 226/1089 - (20%)

  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKR-----VSSWIWR 162
            |..||||||||:|||.|||:||.:::...:..:...|.:..||.....:|..:     |.|  .|
 Frog    13 YEQTLMYGRYTQDLGVFAKEEAARIRQEREVHRPATKPQTVELREYDESRCAKCKICCVHS--QR 75

  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL 227
            ..::|:||||:||.|||::|||:|:.||..|:||..|..|:|..|.:..|:||:|||:.||.||.
 Frog    76 LVLSRVGEDWIFLILLGLLMALVSWAMDFTIAICLQAHKWMYGGLDNNVFLQYLAWVTYPVVLIT 140

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            |||||..::|||::||||||||||||||.||||||.||.:|||||||..||||:||||||||||:
 Frog   141 FSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGLPLGKEGPFVHV 205

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            ||:.|.|||||::.|.|||||||||.||||||||||||.|||||:||||||||||:|:|||||||
 Frog   206 ASMCAALLSKLMSLFGGIYENESRNIEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW 270

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ||||||...|.:||:||||.::.:|:.|||.|:|..:||||.|||..||:||:..|.|||.:|::
 Frog   271 RGFFAATFSAFIFRVLAVWIKDEETITALFKTSFRLDFPFDLQELPAFAVIGIASGFGGALFVYL 335

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTW 487
            :|:.|.|||..|.:|:||.|.|.|:|..:.|||::::||.|.|||:||:|:..|.:..||.|:||
 Frog   336 NRKIVEFMRKQKTINRFLMKKRLLFPALVTLLVATLTFPPGFGQFMAGQLTQKETLVTLFDNYTW 400

  Fly   488 SRDDLTVEQA--AVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGR 550
            ::..::.:.|  .:.:.|.....:||..||::.|..|.:|.:|:|||||.|.|:|||.|||.|||
 Frog   401 AQQGISEDFAYRGISSVWKHPKANVFVTLVVFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGR 465

  Fly   551 LVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMI 615
            ||||.||..||.|:...|....|:|||||||||||.||:||||||.|||:||:||||:|::||||
 Frog   466 LVGESMAAWFPDGIHTDGSTYRIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTGQISHILPVMI 530

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLK 680
            ||::|||||..||||:|||||.||||||||:|.......|::.|||.|:|::.::.....|:.|:
 Frog   531 AVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGHQEKYNVRVEDIMLRNIPFVTLNSKYRDLQ 595

  Fly   681 EVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEK 745
            |:| .|..|:.|.||::.::||||||:.|.:|:.::...:..::|::         |.|..|...
 Frog   596 ELL-TNCHLKCLALVETAESMILLGSIDRSQLLSLLRFQLSSKRRLQ---------QLRERESSG 650

  Fly   746 KKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKT 810
            |||     .....||::.......|          ||  :.||.    .|.|..||.|.|
 Frog   651 KKQ-----TENSVRFQITTEESTFS----------PP--QGETR----KPLKPALKHTLS----- 689

  Fly   811 YAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRT 875
               .:..||:.....::|         |.::||    ..:|.              :..:||.:.
 Frog   690 ---SLTESPADDSDNSVT---------ALKSIF----CAKDF--------------SEPLEVVKD 724

  Fly   876 PSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKF 940
            |::|  |||
 Frog   725 PASP--SKK-------------------------------------------------------- 731

  Fly   941 KANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAES 1005
                                               .|.::|..:.||..::::|..|..:.|
 Frog   732 -----------------------------------NKSRLKHRHRLGEDLDEIDTMTQSQIL--- 758

  Fly  1006 IQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSM 1070
                                   :||..::.:||:|.  |..|||:|||||||||:.|.|::||:
 Frog   759 -----------------------EWEEIQLEEPINLN--NCKIDPAPFQLVERTSLHKAHTVFSL 798

  Fly  1071 VGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSDKAVD 1135
            :|::|||||.||||:|:|.|:|||||||.             ....|.|..:|.|::..     |
 Frog   799 LGMDHAYVTSIGRLIGMVTLRELRKAIEG-------------SVTVKGAKLRPPLASFR-----D 845

  Fly  1136 MTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184
            ...:|.|:..:|.....:....|:.            |:||..|.|.||
 Frog   846 SVTSSSDTETTNVNKLWERSRRHLL------------PRESSPSDSDDK 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	293/476 (62%)
		CBS_pair_SF	659..>718	CDD:449531	22/58 (38%)
		CBS repeat	664..715	CDD:341358	18/50 (36%)
		CBS_pair_SF	<1032..1096	CDD:449531	36/63 (57%)
		CBS repeat	1053..1095	CDD:341358	27/41 (66%)
clcn2	XP_002935192.2	ClC_1_like	84..561	CDD:239655	293/476 (62%)
		COG3448	<550..637	CDD:442671	34/87 (39%)
		CBS_pair_SF	<774..824	CDD:449531	32/49 (65%)
		CBS repeat	781..823	CDD:341367	27/41 (66%)