DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and clcnkb

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_031755485.1	Gene:	clcnkb / 100487225	XenbaseID:	XB-GENE-6049695	Length:	828	Species:	Xenopus tropicalis

Alignment Length:	1054	Identity:	333/1054 - (31%)
Similarity:	506/1054 - (48%)	Gaps:	275/1054 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 EFAKDEARKLKILEKRRKQEDKQRNKELLGKHS-----------TRAKRVSSWI----------W 161
            |.|::::..|.|:|::.|:.|.:...|:....:           .|.:|..:.|          .
Frog     5 EGAEEKSVTLDIVERKEKRGDSKAESEMTESEAYSYGAADKDPQGRLQRAQNGIARLLRPIGLAL 69

  Fly   162 RHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLI 226
            |..:.||||||:||.||||.||.:||.:|..|:....|.:|:|..|....::||.:||...|.|:
Frog    70 RRLLVRLGEDWIFLFLLGISMATISFGLDVTIAKLQRANLWVYDALDRYRYLQYFSWVLYHVLLM 134

  Fly   227 LFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKEGPF 289
            :.|||....|:||:.||||||:|..||||.|.|:.|.:|.:||:||:|.||  ||.:.|||.|||
Frog   135 ITSAGMAKYISPQAAGSGIPEIKVTLRGVVLAEFFTLRTFIAKLIGVTCTLAAGSTIFLGKVGPF 199

  Fly   290 VHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVR 354
            ||:|:|:|..|.:|:....|..||.||..|||.|..||||..||.|||||||||:|.|.|:||||
Frog   200 VHMATILATQLGRLMVKLVGAKENPSRKYEMLVAGAAVGVACCFVAPVGGVLFSVEATATHFAVR 264

  Fly   355 NYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASY 419
            |||||||||.|.|.:||||||..:..:||..||.||:..|||||..|...:|::|:|||.....|
Frog   265 NYWRGFFAATCAALMFRLLAVINREKETVAILFSTNWRVEFPFDLPEYLSYAILGVVCGCLCCVY 329

  Fly   420 VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAG-ELSTHEQVTQLFS 483
            :::||..:||::::.|::..|:.||.:|..|:|.:::||:||.|.||:|.| .|:..|.:...|:
Frog   330 LFLHRTTLLFLQNHPRISTLLRNNRMVYAAFVAWVLASITFPHGFGQYLGGTRLTMKEHLETFFN 394

  Fly   484 NFTWSRDDLTVEQAAVVT-------------HWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.||..::|::  .|.::             .|.....|....|..:.:..|.:.:.|:|:.:|:
Frog   395 NITWGIEELSL--GANISGQPPNPSYSNNFLQWTHPNMSTLEILTCFVVLKFFMLLFANTMIIPA 457

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|||..|||.|||.||.||..||:|:...|....|.|.|||:.||||:||:||.|:|.|:::
Frog   458 GYFLPVFVYGAGLGRLYGEIMAKIFPNGIVSEGIPIKITPAGYALAGAAAYSGAVTQTLSTALLV 522

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVR 665
            ||::||::|::||:||||:|||::...|.|.:|.|::||||||||.|....:..:.|..|||||.
Frog   523 FELSGQMSHILPVLIAVLIANAISQNYQSSFFDLIVIIKKLPYLPKLAMGQNSAHDICAEDFMVT 587

  Fly   666 DVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQ 730
            |::|:..|..|:.::.:|| :..|:..|.|||.::.:|||...|..|.|::.:.:..|:|::.
Frog   588 DLQYLVKGFRYRDIRSLLK-SSELKQFPFVDSEESKVLLGCFSRKSLAKLLAEQLSTERRIQF-- 649

  Fly   731 KWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAP 795

Frog   650 ----------------------------------------------------------------- 649

  Fly   796 RKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGS 860
               :|.||.           |..|                                :.|..|.|
Frog   650 ---MLDKTG-----------GKFP--------------------------------ITPSGENG- 667

  Fly   861 LSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKAL 925
                                                ||:        .|:.:|: .|.:::|...
Frog   668 ------------------------------------TDE--------KTDLHKI-EECEYSDTTY 687

  Fly   926 SNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSI 990
            |                                     |.|..|..|..:.|
Frog   688 S-------------------------------------AQETVVYESEEKQK------------- 702

  Fly   991 EDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQL 1055
                  |..||......|.||..|   ::::       :||..::.:.:.|:.  :.|||:|::|
Frog   703 ------TRTESRRRRSAKFKSHYL---KMVE-------EWECRQLNEEVPLEL--LTIDPTPYRL 749

  Fly  1056 VERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEK--- 1117
            :|:.::.:.:.||:::|:..||||:||||||||.|.|:::|::.....:|.|..|.::..|:
Frog   750 LEKETLYQCYDLFNLLGLRTAYVTRIGRLVGVVSLSEIKEAVDGTVKGTFTPRARAQEQSEETIR 814

  Fly  1118 -----PAVEKPLLS 1126
                 ||...|.:|
Frog   815 LNPLAPAAPGPNVS 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	228/490 (47%)
		Voltage_CLC	227..615	CDD:279048	186/403 (46%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	32/95 (34%)
clcnkb	XP_031755485.1	ClC_1_like	79..567	CDD:239655	227/489 (46%)
clcnkb	XP_031755485.1	CBS_pair_voltage-gated_CLC_euk_bac	581..790	CDD:341367	77/436 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010