DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and clcn2a

DIOPT Version :9

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001315638.1	Gene:	clcn2a / 100150892	ZFINID:	ZDB-GENE-070705-19	Length:	979	Species:	Danio rerio

Alignment Length:	1123	Identity:	458/1123 - (40%)
Similarity:	613/1123 - (54%)	Gaps:	242/1123 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKILEK---RRKQEDKQRNKELLGKHS---TRAKRVSSWIW 161
            |..||||||||::||.:||:||.:|:  |.   ||....:.:..|||....   .:.:..:|...
Zfish    13 YQQTLMYGRYTQELGAYAKEEAARLR--EDGGLRRTTSVRGQAPELLEYEKDPCAKCQVCTSRCK 75

  Fly   162 RHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLI 226
            :..::|:||||:||.|||::|||:|:.||..|:.|..|:.|:||.|.|...:||:|||:.||.||
Zfish    76 KFLISRVGEDWIFLILLGLLMALVSWAMDYTIAFCQQAQKWMYRGLHSNMLLQYLAWVTYPVVLI 140

  Fly   227 LFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVH 291
            .|||||..::|||::||||||||||||||.|||||||||.||||||||..|||||||||||||||
Zfish   141 TFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTFKTFVAKVIGLTCALGSGMPLGKEGPFVH 205

  Fly   292 IASIVAQLLSKLVTSFQGIY--------ENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTT 348
            :||:.|.||||.:..|.|||        :||.||:|||:||||||||.|||||:||||||||||:
Zfish   206 VASLCAALLSKFMALFGGIYMEEPFEGNKNELRNTEMLSAACAVGVGCCFAAPIGGVLFSIEVTS 270

  Fly   349 TYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCG 413
            |:|||||||||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||::|:..|
Zfish   271 TFFAVRNYWRGFFAATFSAFIFRVLAVWNKDEETITALFKTRFRLDFPFDLQELPAFAVLGIASG 335

  Fly   414 LGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQV 478
            .|||.||:::|..|..||..|.:||||.|.|.:||..:.||:|:::||.|.|||:||:|:.||.:
Zfish   336 FGGALYVYLNRIIVESMRKQKTINKFLLKKRLVYPAVVTLLISTLTFPPGFGQFMAGQLTQHESL 400

  Fly   479 TQLFSNFTWSRDDLTVE---QAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIP 540
            ..||.|.||.:..:..|   .:.|...|.....|||..|:::.:..|.:|.:|:|:|||.|.|:|
Zfish   401 VALFDNLTWYKQGVAEEFEYSSHVPQAWKHPQVSVFITLLLFIVMKFWMSAVATTMPVPCGAFMP 465

  Fly   541 VFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTG 605
            ||.|||.|||||||.||..||.|:.....:.||:|||||||||||.||:||||||.|||:||:||
Zfish   466 VFLIGAAFGRLVGESMAAFFPDGIHADSTVYPIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTG 530

  Fly   606 QITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYI 670
            ||:|::||||||::|||||..||||:|||||.|:||||||: |......|:|.|||.|||||:||
Zfish   531 QISHILPVMIAVILANAVAQSLQPSLYDSIIRIQKLPYLPE-LGWGQEKYNIRVEDIMVRDVRYI 594

  Fly   671 WHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKE 735
            ....||:.|:|.| :...|::|.||:|.::||||||::|.:|..::.:.:||.:|:|.
Zfish   595 TLSSSYRDLQEAL-VTGQLKTLALVESKESMILLGSIERSQLQSLLSQQLGRPRRLEY------- 651

  Fly   736 AQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSIL 800
                                               ||:.|.|            :|:
Zfish   652 -----------------------------------LRERAQD------------NGT-------- 661

  Fly   801 KKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAA 865
                            |.|:.||.:........|        |..||         |..|.||..
Zfish   662 ----------------HVPTFTPDSPPKAGRGVR--------FLIST---------EESSYSPTL 693

  Fly   866 SNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGD 930
            :|.                 |:|.:|                        |.|  |..|:||. |
Zfish   694 TNS-----------------QIPLKS------------------------ALK--TVSAISNT-D 714

  Fly   931 SSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDE 995
            |...||::.                  |            |.|.:               |.|:.
Zfish   715 SLNSSPNLS------------------C------------GEPVK---------------ELVES 734

  Fly   996 TTNPESLAESIQKPKSVRLPRERVI----DMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLV 1056
            ...|.:...| ::||.|::|.....    |||..:..:||.:::.:.::..  |..|||:|||||
Zfish   735 NAGPMAPKRS-RRPKRVKIPMADTADVEDDMSTAEIAEWEEQQLDEAVNFN--NCKIDPAPFQLV 796

  Fly  1057 ERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIE---DINSNSFVPPT---RDEDAD 1115
            ||||:.|.|::||::|::|||||..|||||||.|||||||||   .:......||.   ||....
Zfish   797 ERTSLHKTHTIFSLLGLDHAYVTSTGRLVGVVSLKELRKAIEGSVTVTGVKVRPPLASFRDSGNS 861

  Fly  1116 EKPAVEKPLLSTNSSDKAV------------DMTVTSMDSALSNSENCSDIEMEHIK-HTDKGTV 1167
            ...:....|....|..|::            |.|....:.:|.|...|:::..::.. |||
Zfish   862 SSVSEVTELHKLWSRHKSLSLPREINLPDLDDQTEQPSEGSLVNETECTELSSQNSPLHTD---- 922

  Fly  1168 SLTMPPQESKQSPSADKS 1185
                   :..:.|.||.|
Zfish   923 -------DQSELPYADTS 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	291/485 (60%)
		Voltage_CLC	227..615	CDD:279048	237/398 (60%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	45/99 (45%)
clcn2a	NP_001315638.1	ClC_1_like	85..571	CDD:239655	291/485 (60%)
		Voltage_CLC	138..550	CDD:279048	247/411 (60%)
		CBS_pair_EriC_assoc_euk_bac	<788..836	CDD:239964	34/47 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	502	1.000	Domainoid score	I334
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	781	1.000	Inparanoid score	I505
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	1	1.000	-	-		FOG0002718
OrthoInspector	1	1.000	-	-		otm24854
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	O	PTHR45720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4171
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870