DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and MTMR6

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_001372159.1	Gene:	MTMR6 / 9107	HGNCID:	7453	Length:	659	Species:	Homo sapiens

Alignment Length:	761	Identity:	170/761 - (22%)
Similarity:	282/761 - (37%)	Gaps:	229/761 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   961 GALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQ 1025
            |.|:||...::|                   |.|..||     .::.|......|.|.|.:|...
Human    27 GTLYLTATHLLF-------------------IDSHQKE-----TWILHHHIASVEKLALTTSGCP 67

  Fly  1026 LIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKK 1090
            |:          .|.::||.:     |.....|......|.::||    |..:.||..|..|:
Human    68 LV----------IQCKNFRTV-----HFIVPRERDCHDIYNSLLQ----LSKQAKYEDLYAFS-- 111

  Fly  1091 TLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVE 1155
                      :..||....:|           |..|.||
Human   112 ----------YNPKQNDSERL-----------QGWQLID-------------------------- 129

  Fly  1156 RMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQR 1220
                  ..:::||:|.   ....:::|:||..|..|.:||..:..|...|...|:...:.....|
Human   130 ------LAEEYKRMGV---PNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGR 185

  Fly  1221 IPLPTWRHAN-GALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLT 1284
            .|:.::.|.: .|.:.|..||.|......|                   :|::.|..|:   |..
Human   186 FPVLSYYHQDKEAAICRCSQPLSGFSARCL-------------------EDEHLLQAIS---KAN 228

  Fly  1285 PLALNQY-----SGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKG 1344
            |  :|:|     :.....|.|..  ::..|...:...:|.|.:|:..|.:.|:
Human   229 P--VNRYMYVMDTRPKRRMQSWW--ATQKDIGRIIVRISSKIQNDEKIRESNE------------ 277

  Fly  1345 NPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCAD----FIPVDYPDIRQSRPAFKKLIRACMPS 1405
                       |.||.|:..::..|...|.|..::    |:.::  :|...|.:.:||:..
Human   278 -----------KKRLNAMANRAAGKGYENEDNYSNIRFQFVGIE--NIHVMRSSLQKLLEV---- 325

  Fly  1406 HNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQL 1470
            :.|.......|...:|.|.||:.|.::|..:..:...|.::.:||::...||.|.|:|:.|:..|
Human   326 NGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSL 390

  Fly  1471 CLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNL---KPSHANTNIAFAPTFLQFLDVVHQLQRQF 1532
            .||.|||::.||.||:||:|::|||:|:.|...   .|...      :|.|.|||:.|..|..||
Human   391 LLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEV------SPVFTQFLECVWHLTEQF 449

  Fly  1533 PMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGS 1597
            |.||||::.:|..:..|..||:|..||.:|:.||.:   ..:::|..||
Human   450 PQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREE---LKLKEKTYSL---------------- 495

  Fly  1598 DDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKT-----PIFYNF------LYSGDKSVTL 1651
                  :|..:..|:  ..||.:      |....|..|     .:.:||      .:..|:  ||
Human   496 ------WPFLLEDQK--KYLNPL------YSSESHRFTVLEPNTVSFNFKFWRNMYHQFDR--TL 544

  Fly  1652 RPQNNVAALDLWCYYTNEELAQGAPYDLEVTTVDDEIDLSETKGKR 1697
            .|:.:|..:.:   ..||:..|     ||....|.|..:.:.|.|:
Human   545 HPRQSVFNIIM---NMNEQNKQ-----LEKDIKDLESKIKQRKNKQ 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	18/85 (21%)
		Myotub-related	1161..1565	CDD:284109	107/416 (26%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
MTMR6	NP_001372159.1	PH-GRAM_MTMR6	1..101	CDD:270151	24/116 (21%)
MTMR6	NP_001372159.1	PTP_DSP_cys	130..469	CDD:421693	101/402 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840