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Protein Alignment Sbf and MTMR3

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_066576.1	Gene:	MTMR3 / 8897	HGNCID:	7451	Length:	1198	Species:	Homo sapiens

Alignment Length:	893	Identity:	230/893 - (25%)
Similarity:	332/893 - (37%)	Gaps:	295/893 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   924 IQTPCLLPGEDLVTDHLRCFLMPDGREDE-------------TQCLIPAEGALF-LTNYRVIFKG 974
            ||...:.|.:.|:            ||||             |:.:..||.|:. |:|||:..|
Human    12 IQANQIFPRKQLI------------REDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIK- 63

  Fly   975 SPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEV---- 1035
                                 .||.      |.::...|.|.::.| ..|||.....|.:|
Human    64 ---------------------FKES------LVNVPLQLIESVECR-DIFQLHLTCKDCKVIRCQ 100

  Fly  1036 --TPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKK 1098
              |.||.:.:.|.|:.|..|                    |.|.::.:|
Human   101 FSTFEQCQEWLKRLNNAIRP--------------------PAKIEDLFS---------------- 129

  Fly  1099 AGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYV 1163
                            :.| .|...|..:.:.| :.||......:...|.  ..:||||
Human   130 ----------------FAY-HAWCMEVYASEKE-QHGDLCRPGEHVTSRF--KNEVERM------ 168

  Fly  1164 QDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH 1228
                  |||..:  .:||||.|..|..|.|||..::.|...:|..:..:......:|||...:||
Human   169 ------GFDMNN--AWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRH 225

  Fly  1229 -ANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYS 1292
             :|||::.|.|||         :.:.....||  |..|          |:.::.|.. .:.::.|
Human   226 QSNGAVIARCGQP---------EVSWWGWRNA--DDEH----------LVQSVAKAC-ASDSRSS 268

  Fly  1293 GMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGN-KSSQGGKGGTMKGNPKNSLAHPFRK 1356
            |..||                |...||...|..|:||.. .||.....|.      .|||...:|
Human   269 GSKLS----------------TRNTSRDFPNGGDLSDVEFDSSLSNASGA------ESLAIQPQK 311

  Fly  1357 M-----RLYALGEKSQAKSNMNVDFCADFIP------VDYPDIRQSRPAFKKLIRACMPSHNTNE 1410
            :     |.||....::||.....  |.::.|      :...:|...|.:|:.|...|     |..
Human   312 LLILDARSYAAAVANRAKGGGCE--CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLC-----TQM 369

  Fly  1411 ADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPY 1475
            .|..::...:|.:.||..:|.|::.:..||..:|..:..|::...||.|.|.|:.::|:|.||||
Human   370 PDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPY 434

  Fly  1476 YRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFND 1540
            ||:::||:||||.|||.|||:||.|.....:..:.| ...|.|||:||.|||||||||.:||||:
Human   435 YRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLN-ERCPVFLQWLDCVHQLQRQFPCSFEFNE 498

  Fly  1541 FYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYP 1605
            .:|..|..|:.||.|.|||.:...||.:               ||.          .:..|||:.
Human   499 AFLVKLVQHTYSCLFGTFLCNNAKERGE---------------KHT----------QERTCSVWS 538

  Fly  1606 LDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLW------C 1664
            |                      .|..||.  |.|.|||......|.|..:|..|.||      |
Human   539 L----------------------LRAGNKA--FKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPC 579

  Fly  1665 YYTNEELAQG-APYDLEVTTVDDEIDLSETKGKRMVITAGYDNM------------EKC-NPSAY 1715
            ......:... |||....|:.||. .||     |:..|..|||:            .:| :||
Human   580 PSPTTPVDDSCAPYPAPGTSPDDP-PLS-----RLPKTRSYDNLTTACDNTVPLASRRCSDPS-- 636

  Fly  1716 VCLLSEVKQAETERGHLPQKWLQVWNSLEVPQL-----EPVARNTSLG 1758
                            |.:||.:...|||:..|     :|::.: |||
Human   637 ----------------LNEKWQEHRRSLELSSLAGPGEDPLSAD-SLG 667

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.