DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and YMR1

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_012644.1	Gene:	YMR1 / 853574	SGDID:	S000003871	Length:	688	Species:	Saccharomyces cerevisiae

Alignment Length:	495	Identity:	114/495 - (23%)
Similarity:	186/495 - (37%)	Gaps:	176/495 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1163 VQDWKRLGFDAESQR-GFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTW 1226
            :::::|.|.|::.:. .:|:|..|..|..|.:||:.:..|...||..:.|..:....:|||:.|:
Yeast   162 IKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTY 226

  Fly  1227 RH-ANGALLIRGGQP-----NSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTP 1285
            .| |....::|..||     |.:|:                       ||:          ||..
Yeast   227 HHKATDCNILRSSQPLPGLINQRSI-----------------------QDE----------KLVW 258

  Fly  1286 LALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPK-NS 1349
            .:.|.:.                                      ||..:..|...:...|: |:
Yeast   259 ESFNSFC--------------------------------------NKDIRRTKHVIVDARPRTNA 285

  Fly  1350 LAHPFRKMRLYALGEKSQAKSNMNVDFCAD-----------------FIPVDYPDIRQSRPAFKK 1397
            ||.       .|||..::...|.|. |.||                 |:.:|...|..:..|:
Yeast   286 LAQ-------MALGGGTENMDNYNF-FLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAY-- 340

  Fly  1398 LIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTA 1462
            :........:.|....|:..:..:.|:||:..:.:::....::..|....|:|::...||.|.|:
Yeast   341 MTEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTS 405

  Fly  1463 QLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAF------------- 1514
            |:.|:.::||||:||:.:||.:||||:|.:|||||..||    .|.|::|.|
Yeast   406 QVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERS----GHLNSDIRFHDNTMHSNFNDVD 466

  Fly  1515 -----------------------------------------------------APTFLQFLDVVH 1526
                                                                 :|.|.||||.|:
Yeast   467 TNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVY 531

  Fly  1527 QLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELER 1566
            ||..|.|..||||:.:||.|.||..||::.|||.:.|.|:
Yeast   532 QLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396
		Myotub-related	1161..1565	CDD:284109	113/492 (23%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
YMR1	NP_012644.1	PH-like	1..>44	CDD:418428
YMR1	NP_012644.1	Myotub-related	152..570	CDD:399535	113/492 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010