Protein Alignment Sbf and Sbf1

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: XP_006521601.1
• Gene: Sbf1 / 77980
• MGIID: 1925230
• Length: 1901
• Species: Mus musculus
• Alignment Length: 2092
• Identity: 852/2092 - (40%)
• Similarity: 1184/2092 - (56%)
• Gaps: 294/2092 - (14%)

  Fly     1 MSRLADYFVIVGYDSDKEKTASNVGGQPTCGKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSLSYE 65
            |:|||||||:|.:......:..   ||   |:|:||||||||.|.||.:|||.||||.||.|..|
Mouse     1 MARLADYFVLVAFGPHPRGSGE---GQ---GQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPE 59

  Fly    66 KQEPKFFVSVLTDIDANKHYCACLSFHETVAITQ----TRSVDDEDETI---GSSRLLGATPSSM 123
            :..|.|||:|||||::.:||||||:|.|.|..||    |.:..:::|..   |.:||....|:.
Mouse    60 RNPPTFFVAVLTDINSERHYCACLTFWEPVESTQEVVCTDNATEKEEEADGGGQARLSSTAPAQ- 123

  Fly   124 DGITTTSTPASITHHSVMYAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYGLETLIGNILGC 188
                    |..      ::|||.|||:||||.||.|:|.||.||.:::|.|...||.:|||:|.|
Mouse   124 --------PGQ------LFAPKTLVLVSRLDHAEVFRNSLGLIYAIHVEGLNVSLENVIGNLLTC 174

  Fly   189 IQVPPAGGPQV--------RFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLGIKNVLILLCSV 245
             .||.|||.|:        ..|:||||:|.:|.|...|||.:...|..||:||||.|||.|.|:.
Mouse   175 -TVPLAGGSQLDSVEEGARTISLGAGDRQVIQTPLVDSLPVSRCSVALLFRQLGITNVLSLFCAA 238

  Fly   246 MTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQTE 310
            :||:|:||||:.|..|.|:||.|:||::|.||:..|:|||||.|.||||||||||:|::::.|.|
Mouse   239 LTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAE 303

  Fly   311 ITDLLDVIVVDLDGGLVTIPESLTPPVPILPSPLWEQTQDLLSMILFPNLAQADLAFPTLERPSA 375
            ..:||||||.|||||.||:||.:  .:|.||.||..||.::|||:|.|.|..||||||.   |:.
Mouse   304 TQELLDVIVADLDGGTVTVPECV--HIPPLPEPLQSQTHNVLSMVLDPELELADLAFPP---PTT 363

  Fly   376 IAKTDAQIDKELRAIFMRLFAQLLQGYRSCLTIIRIHPKPVITFHKAGFLGARDLIESEFLFRVL 440
            .|.:....||||||:|:|||||||||||.||.|:||||:|||.||||.|||.|.|:|.:||.:||
Mouse   364 SASSLKMQDKELRAVFLRLFAQLLQGYRWCLHIVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL 428

  Fly   441 DSMFFTTFVNERGPPWRSSDAWDELYSSMNELLKSEAQNRNLVGRTQRFKGYFNFTFPSYFQILT 505
            :.|.|..||:|||.|:|::|.:|||.:  :|:.:..|..                :.|  .::|.
Mouse   429 EGMAFAGFVSERGVPYRATDLFDELVA--HEVARMRADE----------------SHP--HRVLR 473

  Fly   506 HIQELGRVLYENEGTLAHISYAQKVLRPPEGA-FQRIHQPAFPRISSEKVELIIQEGIRK-NGVP 568
            |:|||...||:||.....:: ..||.||.|.: .:|.|:| |||:....::.|:.:...| .|.|
Mouse   474 HVQELAEQLYKNENPYPAVA-MHKVQRPGEASHLRRTHRP-FPRLDEGTIQWIVDQAAAKMQGAP 536

  Fly   569 QRFHVTRNQHRIIPMGPRLPEALD--VRPNVQNSARRLEVLRICVSYIFENRITDARKLLPAVMR 631
            ..  |...:...:|.||.:...|:  ..|:: ||||||||:|.|:||:||.::.:|:||||||:|
Mouse   537 PA--VKAERRSTVPSGPPMTAILERCSGPHI-NSARRLEVVRNCISYVFEGKMLEAKKLLPAVLR 598

  Fly   632 TLMHRDARLILCREFFGYVHGNKAVLDHQQFELVVRFMNKALQKSSGIDEYTVAAALLPMSTIFC 696
            .|..|.||..|..|...:|..|:||||||||:.|||.||..||..:.:||:.:|:||||:.|.||
Mouse   599 ALKGRAARRCLAHELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIASALLPLVTAFC 663

  Fly   697 RKLSTGVVQFAYTEIQDHAIWKNLQFWESTFFQDVQGQIKALYL-------LHRRQNEHQKEANC 754
            ||||.||.||||:.:|:|.:|...||||:.|:.|||..|:||||       ..:...|.|.:.
Mouse   664 RKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPSDGVSPTQETGEAQSQD-- 726

  Fly   755 VLDEVPLEEPTALEITAEQLRKSPNIEEEKKAELAKSEESTLYSQAIHFANRMVSLLIPLDVNVD 819
                   :|.:||::.:||.|..|.:..||:.||.:.||||::|||||:||||..||:|||.:..
Mouse   727 -------DERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKS 784

  Fly   820 AASKPKPAF-RLE--ENQSVSNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEG 881
            ...:.:... .||  .|..|:||:.||.:.|..::.|||:....::...|.:.|:||:|.||||.
Mouse   785 RLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTES 849

  Fly   882 GVTSEHIRNLHDMVPGVVHMHIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMP 946
            ||||:|::.||.|||.:|.||||:||.|:.|:||.|.:||||:..|.|||||:.|.|.||.:|:|
Mouse   850 GVTSDHLKGLHVMVPDIVQMHIETLEAVHRESKRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLP 914

  Fly   947 DGREDET------QCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLY 1005
            ||||:..      ..|:|||||:|||.|||||.|.|.|||..|||:||:||:|:|.|||:|||
Mouse   915 DGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISV-- 977

  Fly  1006 LAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQ 1070
            ...:||.|.:||||||.:|||:|:|||.||..:..|.|||.|.|.|:|.|....|||........
Mouse   978 QTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTP 1042

  Fly  1071 GVAPLKTKEK---YSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDEL 1132
            |..|..||:|   :.||    .:.|::.|||...:|....|:.....:::......|.|  :||:
Mouse  1043 GRPPRVTKDKGPSFRTL----SRNLMKNAKKTIGRQYVTRKKYNPPGWEHRGQPPPEDQ--EDEI 1101

  Fly  1133 EDGDEFETQNNAMPRLLT----TKDVERMR-----ERSYVQDWKRLGFDAES-------QRGFRI 1181
            ...:|.|      |..||    .|..:||.     ||:..:|::|||....|       ...|||
Mouse  1102 SVSEELE------PSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRI 1160

  Fly  1182 SNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG-ALLIRGGQPNSKSV 1245
            |..|..||.|||||.:::.|....|.|:..:.||::..|.|:..||.... |:|:|.|..:.|.|
Mouse  1161 SPVNRMYAICRSYPGLLIVPQSIQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGV 1225

  Fly  1246 IGMLK-NTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMN----LSMSSLMGHS 1305
            :|:.| ..|.|...|..|.:.. ||:||..|::::||:..     ..||.|    .|.:.:.||.
Mouse  1226 VGLFKAQNTPSPGQAQADSSSL-EQEKYLQAVVSSMPRYA-----DSSGRNTLSSFSSAHMGGHV 1284

  Fly  1306 SSDDRQ------PLTPELSR----KHKNNLDISDGNKSSQGGK-GGTMKGN------------PK 1347
            .|...:      ||....||    :.|.:...:.|..|..|.. |..:.|.            |.
Mouse  1285 PSPRARVTTLSNPLAASASRWTASRGKWSSVRASGRSSGLGSDVGSRLAGRDLLSTPHTNGAPPD 1349

  Fly  1348 NSLAHPFRKMRLYALGEKSQAKSNMNVDFCA--DFIPVDYPDIRQSRPAFKKLIRACMPSHNTNE 1410
            :....| ::..||.:|:|:|.| .:..|...  :.:|::..:.||.:.:||||::||:|.....|
Mouse  1350 SGFLRP-QRAALYIIGDKAQLK-GVRPDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPATE 1412

  Fly  1411 ADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPY 1475
            ....||.:.:|.|:||.||..|:|:|..||:|:| ..|||::|||||.|:|.|:.|:.||..||:
Mouse  1413 PSPASFLRSLEDSEWLIQIHKLLQISVLVVELLD-SGSSVLVSLEDGWDITTQVVSLVQLLSDPF 1476

  Fly  1476 YRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSH--ANTNIAFAPTFLQFLDVVHQLQRQFPMAFEF 1538
            ||:|:|||:|||||||:|||||:||.    :|  |..:..|.|.||||||.|||:..||||.|||
Mouse  1477 YRTLEGFRLLVEKEWLSFGHRFSHRG----AHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEF 1537

  Fly  1539 NDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAME--DKRGSLNAKHMFGAGGMATNGSDDEC 1601
            :.|||:||.||..|.||||||.|.:.||.:.|:...|  ::||.|..|
Mouse  1538 SQFYLKFLGYHHTSRRFRTFLLDSDYERIELGLLYEEKGERRGQLACK----------------- 1585

  Fly  1602 SVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWCYY 1666
                                 |:::|::|...:||:|||:.|:.:.:..|||.:||:.|.:|.:|
Mouse  1586 ---------------------SVWEYVDRLSKRTPMFYNYTYAPEDTEVLRPYSNVSNLKVWDFY 1629

  Fly  1667 TNEELAQGAPYDLEVT------TVDDEIDLSETKGKRMVITAGYDNMEKCNPSAYVCLLSEVKQA 1725
            |.|.||:|.|||.|:.      ..::..|....:.:|.|:...||:..:..|.|...||.|:::.
Mouse  1630 TEETLAEGPPYDWELAQGPPEPPEEERPDGGAPQSRRRVVWPCYDSRPRVQPDAISRLLEELQRL 1694

  Fly  1726 ETERGHLPQKWLQVWNSLEVPQ-LEPVARNTSLG---NIFVQTHQHKRSTLEIIMKGRLAGYQDK 1786
            |||.|...::|...|:.::..| ||  :|....|   ::.|....|.|.:|.:.::.
Mouse  1695 ETELGRPSERWKDTWDRVKAAQRLE--SRQDGRGTPSSLLVSAVPHHRRSLGVYLQE-------- 1749

  Fly  1787 YFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEKCTEHSMKNCTKYKAIDGAVGPP 1851
                                      ||||                     .|...::|.
Mouse  1750 --------------------------GPVG---------------------STLSLSLDS----- 1762

  Fly  1852 NVNMSQGDTASIASSAATTARTSSHHFYNQFSSNVAENRTHEGHLYKRGALLKGWKQRWFVLDSI 1916
              :.|.|.|   .||:...||.|:...|:||.:..:|||::||.|||:||.:|.||.||||||..
Mouse  1763 --DQSSGST---TSSSRQAARRSTSTLYSQFQTAESENRSYEGILYKKGAFMKPWKARWFVLDKT 1822

  Fly  1917 KHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGA-KGVDEKGFFDLKTSKRIYNFYAINANL 1980
            ||||||||...||..||:|:||||::|....|. ||| |.||||.|||:||::|:|||.|.:...
Mouse  1823 KHQLRYYDHRMDTECKGVIDLAEVEAVAPGTPT-IGAPKTVDEKAFFDVKTTRRVYNFCAQDVPS 1886

  Fly  1981 AQEWIEKLQACL 1992
            ||:|::::|:||
Mouse  1887 AQQWVDRIQSCL 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824	50/89 (56%)
		DENN	142..325	CDD:460461	103/190 (54%)
		dDENN	384..452	CDD:129037	46/67 (69%)
		SBF2	584..807	CDD:463536	109/231 (47%)
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	67/119 (56%)
		PTP-MTMR5-like	1179..1531	CDD:350382	141/384 (37%)
		C1_Sbf-like	1790..1840	CDD:410377	4/49 (8%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	62/106 (58%)
Sbf1	XP_006521601.1	uDENN	1..86	CDD:214824	50/90 (56%)
		DENN	129..318	CDD:214823	103/189 (54%)
		dDENN	372..440	CDD:129037	46/67 (69%)
		SBF2	550..772	CDD:463536	109/231 (47%)
		PH-like	901..1019	CDD:473070	67/119 (56%)
		PTP_DSP_cys	1158..1530	CDD:475123	141/384 (37%)
		PH_Sbf1_hMTMR5	1794..1899	CDD:269941	62/106 (58%)