DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr2

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_036011299.1	Gene:	Mtmr2 / 77116	MGIID:	1924366	Length:	718	Species:	Mus musculus

Alignment Length:	928	Identity:	210/928 - (22%)
Similarity:	313/928 - (33%)	Gaps:	372/928 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 PAFRLEENQSVSNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEGGVTSEHIRN 890
            ||.||....|:|:      :.:.||:......:|..|.          .|.:.|.....|..:|
Mouse    83 PAARLPSEDSLSS------ASTSHSENSVHTKSASAIS----------SDSISTSADNFSPDLR- 130

  Fly   891 LHDMVPGVVHMHIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQC 955
                              |..||.:     ..:::.|.|||||::          .|..:|.|.
Mouse   131 ------------------VLREANK-----LAEMEEPALLPGENI----------KDMAKDVTY- 161

  Fly   956 LIPAEGA----LFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKE------------------ 998
            :.|..||    |.:|:||:.||....||.|   |:..:..:.|.:::
Mouse   162 ICPFTGAVRGTLTVTSYRLYFKSMERDPPF---VLDASLGVISRVEKIGGASSRGENSYGLETVC 223

  Fly   999 KKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQ 1063
            |.|..|..||    ..||...||....|:|.||.              :|... |...|||
Mouse   224 KDIRNLRFAH----KPEGRTRRSIFENLMKYAFP--------------VSNGL-PLFAFEY---- 265

  Fly  1064 SYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSI 1128
                          ||.:               .:.|:|.           ||
Mouse   266 --------------KEVF---------------PENGWKL-----------YD------------ 278

  Fly  1129 DDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRS 1193
                             |.|                :::|.|...||   :||:..|..|..|.:
Mouse   279 -----------------PLL----------------EYRRQGIPNES---WRITKINERYELCDT 307

  Fly  1194 YPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG-ALLIRGGQPNSKSVIGMLKNTTGSTT 1257
            |||::|.|....|..:..:.......|||:.:|.|... |.:.|..||    ::|:    :|..:
Mouse   308 YPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQP----MVGV----SGKRS 364

  Fly  1258 NAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHS-SSDDRQPLTPELSRKH 1321
            .         |.:||..|:::                    |:...|. ...|.:|....::
Mouse   365 K---------EDEKYLQAIMD--------------------SNAQSHKIFIFDARPSVNAVA--- 397

  Fly  1322 KNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYP 1386
                     ||:..||.                         |...|..|      |:.:.:|..
Mouse   398 ---------NKAKGGGY-------------------------ESEDAYQN------AELVFLDIH 422

  Fly  1387 DIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSL-------MQLSGA--VVDL 1442
            :|...|.:.:||.....|:              :|::.||..:.|.       :.|:||  :.|.
Mouse   423 NIHVMRESLRKLKEIVYPT--------------IEETHWLSNLESTHWLEHIKLILAGALRIADK 473

  Fly  1443 IDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSH 1507
            ::..::||::...||.|.||||:|:|.|.||.|||::.||.||||||||:|||||    .|:..|
Mouse   474 VESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRF----QLRVGH 534

  Fly  1508 ANTNIAFA---PTFLQFLDVVHQLQR-------QFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDC 1562
            .:.|.|.|   |.||||:|.|.|:.|       |||.|||||:::|..:..|..||.|.|||.:.
Mouse   535 GDKNHADADRSPVFLQFIDCVWQMTRQFVVLNLQFPTAFEFNEYFLITILDHLYSCLFGTFLCNS 599

  Fly  1563 ELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDY 1627
            |.:|....:                                            |...:  |::.|
Mouse   600 EQQRGKENL--------------------------------------------PKKTV--SLWSY 618

  Fly  1628 IERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWC-YYT----------------NEELAQGA 1675
            |..|...   |.|.||....:..|.|..::..|:||. ||.                .|.||:.|
Mouse   619 INSQLED---FTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRA 680

  Fly  1676 PYDLEVTTVDDEIDLSET 1693
            ....:|..:..||....|
Mouse   681 ELQRKVEELQREISNRST 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	31/135 (23%)
		Myotub-related	1161..1565	CDD:284109	119/424 (28%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr2	XP_036011299.1	PH-like	141..255	CDD:418428	36/145 (25%)
Mtmr2	XP_036011299.1	Myotub-related	270..603	CDD:399535	125/489 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840