Protein Alignment Sbf and Sbf2

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: XP_008758019.1
• Gene: Sbf2 / 691042
• RGDID: 1588657
• Length: 1904
• Species: Rattus norvegicus
• Alignment Length: 2107
• Identity: 843/2107 - (40%)
• Similarity: 1215/2107 - (57%)
• Gaps: 321/2107 - (15%)

  Fly     1 MSRLADYFVIVGYDSDKEKTASNVGGQPTCGKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSLSYE 65
            |:||||||::||||.:|.      |.....|||:||||::||.||||.:|||.||||.||.||.|
  Rat     1 MARLADYFIVVGYDHEKP------GPGEGLGKIIQRFPQQDWDDTPFPQGIELFCQPGGWHLSRE 59

  Fly    66 KQEPKFFVSVLTDIDANKHYCACLSFHET-VAITQTRSVDDEDETIGSSRLLGATPSSMDGITTT 129
            :::|.|||.||||||:::|||:||:|:|. :.:..|:..:.|.|.:  |.|:
  Rat    60 RKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEEV--SALI------------- 109

  Fly   130 STPASITHHSVMYAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYGLETLIGNILGCIQVPPA 194
             .||.:      :|||.|||:||||..|.|:.|||.|||||:::|:..||:||.|:..|: ||.|
  Rat   110 -QPAEV------FAPKSLVLVSRLDYPEIFRACLGLIYTVYVDSLSVSLESLIANLCACL-VPAA 166

  Fly   195 GGPQVRFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLGIKNVLILLCSVMTENKILFLSKCYW 259
            ||.|..||:||||:|.:|.|...|||.||:.|..||:||||:|||.|.|:|:||||:||.|..:.
  Rat   167 GGSQKLFSLGAGDRQLIQTPLHDSLPVTGTSVALLFQQLGIQNVLNLFCAVLTENKVLFHSASFQ 231

  Fly   260 HLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQTEITDLLDVIVVDLDG 324
            .|:|:||||.:||:|.:|::.|||||||.|.||||:|||||:|:||..:|::.:|||||:.||||
  Rat   232 RLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSIFKTDVHELLDVIIADLDG 296

  Fly   325 GLVTIPESLTPPVPILPSPLWEQTQDLLSMILFPNLAQADLAFPTLERPSAIAKTDAQIDKELRA 389
            |.:.|||.:  .:..||.||..|||..||:||.|:|..||.|||.   |.........:|||:||
  Rat   297 GTIKIPECI--HLSSLPEPLLHQTQAALSLILHPDLEVADHAFPP---PRTALSHSKMLDKEVRA 356

  Fly   390 IFMRLFAQLLQGYRSCLTIIRIHPKPVITFHKAGFLGARDLIESEFLFRVLDSMFFTTFVNERGP 454
            :|:||||||.|||||||.:||||.:|||.|||..|||.|.|:|::||.:||:.|.|..||:||||
  Rat   357 VFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSERGP 421

  Fly   455 PWRSSDAWDELYSSMNELLKSEAQNRNLVGRTQRFKGYFNFTFPSYFQILTHIQELGRVLYENEG 519
            |:|:.|.:|||.:...|.:|.|..|.                    .:::.||:||...|::||.
  Rat   422 PYRACDLFDELVAFEVERIKVEENNP--------------------LKMIKHIRELAEQLFKNEN 466

  Fly   520 TLAHISYAQKVLRPPEGAFQRIHQPAFPRISSEKVELIIQEGIRK--NGVPQRFHVTRNQHR-II 581
            ...|::: |||.||.||:..|:|...||:|:..:|:.:|||.:.|  |..|    .||.:.: |:
  Rat   467 PNPHMAF-QKVPRPTEGSHLRVHILPFPKINEARVQELIQENLAKNQNATP----ATRTEKKCIV 526

  Fly   582 PMGPRLPEALDVRPNVQNSARRLEVLRICVSYIFENRITDARKLLPAVMRTLMHRDARLILCREF 646
            |.||.:...:|....|.|||:||||:|.|:|:||||:..:..|.|||.:|.|..:.||..|..|.
  Rat   527 PAGPPVVSIMDKVITVFNSAQRLEVVRNCISFIFENKTLETEKTLPAALRALKGKAARQCLTDEL 591

  Fly   647 FGYVHGNKAVLDHQQFELVVRFMNKALQKSSGIDEYTVAAALLPMSTIFCRKLSTGVVQFAYTEI 711
            ..:|..|:|:||||||:.::|.||..||..|.::||.:||||||:::.|.|:|:.||.|||||.:
  Rat   592 GLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRRLAPGVSQFAYTCV 656

  Fly   712 QDHAIWKNLQFWESTFFQDVQGQIKALYLLHRRQNE--HQKEANCVLDEVPLEEPTALEITAEQL 774
            |||.||.|.||||:||:..||.|:::|||..:..|.  |||:..  |.:...:|.||:::.||||
  Rat   657 QDHPIWTNQQFWETTFYSAVQEQVRSLYLSAKEDNHTPHQKQKE--LPDGQYQERTAMDLAAEQL 719

  Fly   775 RKSPNIEEEKKAELAKSEESTLYSQAIHFANRMVSLLIPLDVNVD---AASKPKPAFRLEENQSV 836
            |..|.:.:..:.||.:.||||::||||||||.||:||:|||.:.:   .||.|.. :....|..|
  Rat   720 RLWPTLSKATQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRASAPGD-WESGSNSIV 783

  Fly   837 SNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEGGVTSEHIRNLHDMVPGVVHM 901
            :|||.||.:.|..::.|||::...::..:|.:.|:||||.||||.|||.:|||:||.|:||:|.|
  Rat   784 TNSIAGSVAESFDTESGFEDSENNDVANSVVRFIARFIDKVCTESGVTQDHIRSLHCMIPGIVAM 848

  Fly   902 HIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDET------QCLIPAE 960
            |||:||.|:.|::|.|.:|||||..|.|||||::|.:.||..|.|||||:.|      ..|:|||
  Rat   849 HIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAE 913

  Fly   961 GALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQ 1025
            ||||||.||::|:|:|.|.|..||.:||:|||||:.|||||::  ...|.|.:.||||:.|:|||
  Rat   914 GALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITM--QNQLQQNMQEGLQITSASFQ 976

  Fly  1026 LIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKK 1090
            |||||||.||:||.::.|:|.|.|.|:|...|..|||.:..|..|.:.| |.|||.::.:.|: |
  Rat   977 LIKVAFDEEVSPEVVDIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILP-KQKEKNTSFRTFS-K 1039

  Fly  1091 TLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQ----SIDDELEDGDEFETQNNAMPRLLTT 1151
            |:::||||||   |....|:.:.....|:...:...    :.:|::...|:.|...:...:....
  Rat  1040 TIVKGAKKAG---KMTIGRQYLLKKRTGTIVEERANRPGWNEEDDISVSDDCELPTSTTLKASEK 1101

  Fly  1152 KDVERMRERSYVQDWKRLG---FDAESQRG----FRISNANTSYATCRSYPAIIVAPVQCSDAAI 1209
            ..:|::.|::..:|::|||   ....|.|.    ||::.:|..|:.|||||.::|.|....|:::
  Rat  1102 STMEQLVEKACFRDYQRLGLGTISGSSSRSKPEYFRVTASNRLYSLCRSYPGLLVIPQAVQDSSL 1166

  Fly  1210 MHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPNSKSVIGMLK--NTTGSTTNAHHDVTHYPEQDK 1271
            ..:.||::..|:|:..|::: :|.||:|.|..:.|.|:|:.|  |:..:.:.:..:.:...||:|
  Rat  1167 PRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAVSTSSLESSSSIEQEK 1231

  Fly  1272 YFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQ--PLTPELSRKHK-----------N 1323
            |..||      ||.:.::|         .|.|:|:...|.  .|:|...|:..           .
  Rat  1232 YLQAL------LTAVIVHQ---------KLRGNSTLTVRPTLALSPGTERRSSRMSTVLKQVVPG 1281

  Fly  1324 NLDISDGNKSSQGGKGGTMK----GNPKNSLAHPF------------------------------ 1354
            :||::..|..::|..|...|    .|.|:|...|.
  Rat  1282 HLDVNPSNSFARGVHGYRDKCFTQSNSKSSAKEPVHNQGVWASLRSSTRLISSPTSLIDVGARLA 1346

  Fly  1355 --------------------RKMRLYALGEKSQAKSNMNVDFC--ADFIPVDYPDIRQSRPAFKK 1397
                                |:..||..|||||.:|: .|:|.  .:|:||::.:|||.:.:|||
  Rat  1347 GKDHSASFSNSTYLQNQLSKRQAALYIFGEKSQLRSS-KVEFAFNCEFVPVEFHEIRQVKASFKK 1410

  Fly  1398 LIRACMPSHNTNEADGQ-SFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVT 1461
            |:|||:||  |...|.: :|.|.:|.|:|..|:..:|||:..|.:::: ..|||.:.||:|.|:|
  Rat  1411 LMRACIPS--TIPTDSEVTFLKALEDSEWFPQLHRIMQLAVVVSEVLE-NGSSVWVCLEEGWDIT 1472

  Fly  1462 AQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVH 1526
            .|::|:.||..||:||:::|||:|||||||:|||:|:.||:|..:...:  .|||.||||||.||
  Rat  1473 TQVTSLVQLLSDPFYRTIEGFRMLVEKEWLSFGHKFSQRSSLALNSQGS--GFAPIFLQFLDCVH 1535

  Fly  1527 QLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGG 1591
            |:..|:|..||||.:||:|||:|.||.||:|||.|.:.||.:.|  .:.|.:|..:||.
  Rat  1536 QVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHG--TLFDDKGDKHAKK------ 1592

  Fly  1592 MATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNN 1656
                                         |..|::.|::.|.::|:|:|:|||..:...|:|..|
  Rat  1593 -----------------------------GVCIWECIDKMHKRSPVFFNYLYSPVEIEALKPNVN 1628

  Fly  1657 VAALDLWCYYTNEELAQGAPYDLEVTTVD----DEIDLSETKG---KRMVITAGYDNMEKCNPSA 1714
            |::|..|.|||.|.|:.|..||..:.|..    :|.|::...|   :|..:...||::....|.|
  Rat  1629 VSSLKKWDYYTEETLSAGPSYDWMMLTPKHFPYEESDVAGGAGPQSQRKTVWPCYDDVTCSQPDA 1693

  Fly  1715 YVCLLSEVKQAETERGHLPQKWLQVWNSL-----EVPQLEPVARNTS----LGNIFVQTHQHKRS 1770
            ...|.||:::.|.:....|:||.|:|..:     |.|:.:...|::|    :.:..|.::| ||.
  Rat  1694 LTRLFSEIEKLEHKLNQTPEKWHQLWEKITMDLKEEPRTDHSLRHSSRSPGIASTNVPSYQ-KRP 1757

  Fly  1771 TLEIIMKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEKCTEHSM 1835
            .|..:               ||......:|.|
  Rat  1758 ALHAL---------------HRSPTEDQSTTT--------------------------------- 1774

  Fly  1836 KNCTKYKAIDGAVGPPNVNMSQGDTASIASSAATTARTSSHHFYNQFSSNVAENRTHEGHLYKRG 1900
                         .|.|         .:...|||        .|:|::|...|||:.||.|||||
  Rat  1775 -------------APSN---------GVEHRAAT--------LYSQYTSKNDENRSFEGTLYKRG 1809

  Fly  1901 ALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGAKGVDEKGFFDLK 1965
            |||||||.||||||..||||||||:.|||:.||.|:||||:.|..|.|:....|...:|.|||||
  Rat  1810 ALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVVPAGPSMGAPKYTSDKAFFDLK 1874

  Fly  1966 TSKRIYNFYAINANLAQEWIEKLQACL 1992
            ||||:|||.|.:...||:|::::|:|:
  Rat  1875 TSKRVYNFCAQDGQSAQQWMDRIQSCI 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824	53/89 (60%)
		DENN	142..325	CDD:460461	106/182 (58%)
		dDENN	384..452	CDD:129037	43/67 (64%)
		SBF2	584..807	CDD:463536	107/224 (48%)
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	65/119 (55%)
		PTP-MTMR5-like	1179..1531	CDD:350382	136/424 (32%)
		C1_Sbf-like	1790..1840	CDD:410377	4/49 (8%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	64/105 (61%)
Sbf2	XP_008758019.1	uDENN	1..86	CDD:214824	53/90 (59%)
		DENN	115..297	CDD:460461	106/182 (58%)
		dDENN	351..419	CDD:129037	43/67 (64%)
		SBF2	529..752	CDD:463536	107/224 (48%)
		PH-GRAM_MTMR13	880..998	CDD:275416	65/119 (55%)
		PTP_DSP_cys	1136..1540	CDD:475123	136/424 (32%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941	64/105 (61%)