DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr11

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_001178025.1	Gene:	Mtmr11 / 689613	RGDID:	1589965	Length:	700	Species:	Rattus norvegicus

Alignment Length:	898	Identity:	178/898 - (19%)
Similarity:	285/898 - (31%)	Gaps:	346/898 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   928 CL----LPGEDLVTDHLRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSPC-------DPLF 981
            ||    ||||.::.       ...||.......:|  |.|..||:||.|:  ||       .||.
  Rat    45 CLASGCLPGEHILA-------WAPGRRKGPGLELP--GTLICTNFRVTFQ--PCGWQRNQDTPLS 98

  Fly   982 CEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLR---------SSSFQLIKVAFDP-EVT 1036
            .|.    .|.:.::.:.:.:|.|...   |.|..|.||:         ...|:|:::.|:. .:.
  Rat    99 SEY----DFALINIGRLEAVSGLSRV---QLLRPGSQLKFIPEEVLIHGRDFRLLRIGFEAGGLA 156

  Fly  1037 PEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGF 1101
            |:                      |||....::|..|.....::|..:      ||.:..|.:|
  Rat   157 PQ----------------------AFQVTMAIIQARAQSSQVQQYRGI------TLSKAGKVSG- 192

  Fly  1102 KQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDW 1166
                                                  ::...:|.|.|.:|.|..|::
  Rat   193 --------------------------------------SRKPPIPLLETLEDWETERKK------ 213

  Fly  1167 KRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG 1231
                   :..||:|:|..|..:....|.......|.:..|:.:......|...|.|..:|.|..|
  Rat   214 -------QGARGWRVSMVNERFDVATSLSGYFWVPNRILDSEVRRAFAHFHQGRGPRLSWHHPGG 271

  Fly  1232 ALLIR------GGQPNSKSVIG---MLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLA 1287
            :.|:|      ...||.:.:..   ||:       ..|.||           .|::||.::..||
  Rat   272 SDLLRCAGFYIASDPNKEDIRAVELMLQ-------AGHSDV-----------VLVDTMDEMPSLA 318

  Fly  1288 LNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAH 1352
                                                  |:                     .|||
  Rat   319 --------------------------------------DV---------------------QLAH 324

  Fly  1353 PFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFA 1417
                ::|.||                                       |:|..:..|   ..:.
  Rat   325 ----LKLRAL---------------------------------------CLPDSSVAE---DKWL 343

  Fly  1418 KMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGF 1482
            ..:|.:.||..:.|.::.:..:..|:..:..||:|......|....|||:.||.|.|..|:|.||
  Rat   344 SALEGTRWLDYVRSCLRKASDISVLVTSRVRSVVLQERGDRDFNGLLSSLVQLLLAPEARTLFGF 408

  Fly  1483 RVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLA 1547
            :.||::||:|.||.|..|  |..:.|:..   ||....|||...||.:|||..|||::|:|  ||
  Rat   409 QSLVQREWVAAGHPFLTR--LGETGASEE---APVLPLFLDCAWQLLQQFPAEFEFSEFFL--LA 466

  Fly  1548 YH--------------------SVSCRFRTF----------------------LFDCELERS--- 1567
            .|                    ..|.:|.::                      ::|.:|..|
  Rat   467 LHDSIRVPDTLTFLRNTPWERGKKSGQFNSYTQVYTPEYSQPLAGSPANLHLSVWDWDLRYSKEQ 531

  Fly  1568 ---------------DSGIAAMEDK---RGSLNAKHMFGAGGMATNGS----DDECSVYPLDIRS 1610
                           |||:...:..   .||.::..:|..|.:.....    .|..|:  |.:.|
  Rat   532 ISQFLNPGYDPEHCPDSGLPRQQPSLMVPGSPSSMWLFSRGALTPLNQLCPWQDSTSL--LTVSS 594

  Fly  1611 QRAPAPLNRIGHSIFDY---IERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLW--CYYTNEE 1670
            ...|.|. |...|:.|.   :.......|:....|..|    .|.||     :..|  ||.....
  Rat   595 HWLPRPA-RSSESLADQEWGLPSHWGACPLPPGLLLPG----YLGPQ-----IRFWKRCYLRGRP 649

  Fly  1671 LAQGAPYDLEVTTVDDEID-LSETKGKRMVITAGYDNMEKCNPSAYVCLLSEV 1722
            ..|.....|.::.:.||:. |.|...|.....:..|:.:|.:|:.   :||::
  Rat   650 EVQIGSSALTISGLQDELSHLQELLRKWTPRISPEDHSKKRDPNT---ILSQI 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	28/130 (22%)
		Myotub-related	1161..1565	CDD:284109	90/454 (20%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr11	NP_001178025.1	PH-like	51..165	CDD:302622	34/153 (22%)
		PTPc	195..469	CDD:304379	92/416 (22%)
		3-PAP	553..683	CDD:289355	29/141 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840