DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtmr7a

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_001035406.1	Gene:	mtmr7a / 678558	ZFINID:	ZDB-GENE-060421-7754	Length:	655	Species:	Danio rerio

Alignment Length:	672	Identity:	155/672 - (23%)
Similarity:	239/672 - (35%)	Gaps:	250/672 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1159 ERSYVQDWKRLGFDAE-SQRG-----FRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFK 1217
            ||.:  .|..:...|| |:.|     :.::..|..|..|.:|||.:..|...:...|:...:...
Zfish   122 ERQH--SWDFIDLKAEYSRMGLPNKLWHVTPINRDYRVCDTYPADLFVPKSVTLPVIVGSSKFRS 184

  Fly  1218 GQRIP-LPTWRHANGALLIRGGQP----------NSKSVIGMLKNTTGSTTNAHHDVTHYPEQDK 1271
            ..|.| |..:...|.|.:.|..||          :.:.:..::|:..||.
Zfish   185 RGRFPTLSYYCKENHATICRSSQPLSGFSARCLEDEQMLQAIMKSNPGSR--------------- 234

  Fly  1272 YFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQG 1336
             |:.:::|.|||..:|                                           |:::
Zfish   235 -FMYVVDTRPKLNAMA-------------------------------------------NRAA-- 253

  Fly  1337 GKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIR- 1400
            |||...:.|              |.           |:.|  .||.::  :|...|.:.:|||.
Zfish   254 GKGYENEDN--------------YC-----------NIKF--QFIGIE--NIHVMRNSQQKLIEV 289

  Fly  1401 ACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQ----LSGAVVDLIDLQESSVMLSLEDGSDVT 1461
            :.:.|.:..|     |...:|.||||:.|.|:|:    :|.||.|    :..||::...||.|.|
Zfish   290 SALRSPSMGE-----FLLGLENSDWLKHIRSIMEAGIFISKAVAD----EGVSVLVHCSDGWDRT 345

  Fly  1462 AQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVH 1526
            :|:.|:|.:.||||||::.|..||:||:|::|||:|:||.......|.   ..:|...|||:.|.
Zfish   346 SQVCSVASVLLDPYYRTIKGMMVLIEKDWVSFGHKFSHRCGHLDGEAK---EVSPVLDQFLECVW 407

  Fly  1527 QLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGG 1591
            ||..|||.|||:|:.:|..:..|..|..:..|:.:.:.||.|
Zfish   408 QLMDQFPCAFEYNEKFLISIHNHVYSSHYGNFICNSQKERKD----------------------- 449

  Fly  1592 MATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDK---SVTLRP 1653
                          |.||.:.         |||:.|:  ..||.. |.|.|:..|:   ...|||
Zfish   450 --------------LRIREKT---------HSIWPYL--MENKLD-FMNPLFKPDQIQNQGLLRP 488

  Fly  1654 QNNVAALDLWCYYTNEELAQGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNMEKCNPSAYVCL 1718
            .........|....|.       :|.|:.....|:|                           ||
Zfish   489 STAPYCFKYWRRLYNR-------FDRELHPRQSELD---------------------------CL 519

  Fly  1719 LS---EVKQAETERGHLPQK------------WLQ---------VWNSLEVPQLEPVARNTS--- 1756
            ::   |.:|.|.|.....||            ::|         :|:   || |:....||.
Zfish   520 MAVKDETQQLEEEMALYEQKLAVLDKERAKILYMQKGVLESRQALWS---VP-LDVSLANTPQDY 580

  Fly  1757 LG-------NIFVQTHQHKRST 1771
            ||       |:|......|.||
Zfish   581 LGGFIGGAPNVFTSQQGEKEST 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396
		Myotub-related	1161..1565	CDD:284109	106/425 (25%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtmr7a	NP_001035406.1	PH-GRAM_MTMR7	1..103	CDD:270152
mtmr7a	NP_001035406.1	Myotub-related	109..446	CDD:284109	108/427 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840