DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and MTMR9

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_056273.2	Gene:	MTMR9 / 66036	HGNCID:	14596	Length:	549	Species:	Homo sapiens

Alignment Length:	446	Identity:	115/446 - (25%)
Similarity:	180/446 - (40%)	Gaps:	131/446 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1132 LEDG-------DEFETQNNAMPRLLTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYA 1189
            :|||       .|||..::|                  ..:|             |:|..|..:|
Human   120 IEDGWHSFLPEQEFELYSSA------------------TSEW-------------RLSYVNKEFA 153

  Fly  1190 TCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQPNSKSVIGMLKNTT 1253
            .|.|||.|:..|....|.|:..:.....|.|.|:.::.| .||.:::|.|||        |..|.
Human   154 VCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQP--------LTGTN 210

  Fly  1254 GSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELS 1318
            |....         |.:|    |||...:                                   :
Human   211 GRRCK---------EDEK----LINATLR-----------------------------------A 227

  Fly  1319 RKHKNNLDISDGNKSSQ-GGKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIP 1382
            .|....:|....|.:.| ..|||..:..     ||..:..|::...|:
Human   228 GKRGYIIDTRSLNVAQQTRAKGGGFEQE-----AHYPQWRRIHKSIER----------------- 270

  Fly  1383 VDYPDIRQSRPAFKKLIRACM-PSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQ 1446
              |..:::|   ..||:.||. .:||.:.     :...:|.|:||..|..::..:......||.:
Human   271 --YHILQES---LIKLVEACNDQTHNMDR-----WLSKLEASNWLTHIKEILTTACLAAQCIDRE 325

  Fly  1447 ESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTN 1511
            .:|:::...:|:|.|.|::|:||:.|:|..|::.||..|:|:|||..||.|..|. .:.::.||.
Human   326 GASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRC-AQSAYCNTK 389

  Fly  1512 IAF-APTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELER 1566
            ..: ||.||.|||.|.|:.||||.:||||:.:|..|..|:.:.:|.|||.:.|.||
Human   390 QKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESER 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396
		Myotub-related	1161..1565	CDD:284109	106/407 (26%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
MTMR9	NP_056273.2	PH-GRAM_MTMR9	1..97	CDD:275398
MTMR9	NP_056273.2	Myotub-related	127..446	CDD:310891	112/439 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840