Protein Alignment Sbf and SBF1

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: NP_001397723.1
• Gene: SBF1 / 6305
• HGNCID: 10542
• Length: 1894
• Species: Homo sapiens
• Alignment Length: 2066
• Identity: 841/2066 - (40%)
• Similarity: 1178/2066 - (57%)
• Gaps: 249/2066 - (12%)

  Fly     1 MSRLADYFVIVGYDSDKEKTASNVGGQPTCGKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSLSYE 65
            |:|||||||:|.:......:..   ||   |:|:||||||||.|.||.:|||.||||.||.|..|
Human     1 MARLADYFVLVAFGPHPRGSGE---GQ---GQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPE 59

  Fly    66 KQEPKFFVSVLTDIDANKHYCACLSFHETVAITQTRSVDDEDETIGSSRLLGATPSSMDGITTTS 130
            :..|.|||:|||||::.:||||||:|.|....:|..:...||.|       .......:|..|..
Human    60 RNPPTFFVAVLTDINSERHYCACLTFWEPAEPSQQETTRVEDAT-------EREEEGDEGGQTHL 117

  Fly   131 TPASITHHSVMYAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYGLETLIGNILGCIQVPPAG 195
            :|.:....:.::|||.|||:||||..|.|:|.||.||.:::|.|...||.:|||:|.| .||.||
Human   118 SPTAPAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTC-TVPLAG 181

  Fly   196 GPQVRFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLGIKNVLILLCSVMTENKILFLSKCYWH 260
            |.|...|:||||:|.:|.|.:.|||.:...|..||:||||.|||.|.|:.:||:|:||||:.|..
Human   182 GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQR 246

  Fly   261 LTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQTEITDLLDVIVVDLDGG 325
            |.|:||.|:||::|.||:..|:|||||.|.||||||||||:|::::.|.|..:||||||.|||||
Human   247 LADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGG 311

  Fly   326 LVTIPESLTPPVPILPSPLWEQTQDLLSMILFPNLAQADLAFPTLERPSAIAKTDAQIDKELRAI 390
            .|||||.:  .:|.||.||..||..:|||:|.|.|..||||||.   |:....:....||||||:
Human   312 TVTIPECV--HIPPLPEPLQSQTHSVLSMVLDPELELADLAFPP---PTTSTSSLKMQDKELRAV 371

  Fly   391 FMRLFAQLLQGYRSCLTIIRIHPKPVITFHKAGFLGARDLIESEFLFRVLDSMFFTTFVNERGPP 455
            |:|||||||||||.||.::||||:|||.||||.|||.|.|:|.:||.:||:.|.|..||:|||.|
Human   372 FLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVP 436

  Fly   456 WRSSDAWDELYSSMNELLKSEAQNRNLVGRTQRFKGYFNFTFPSYFQILTHIQELGRVLYENEGT 520
            :|.:|.:|||.:  :|:.:..|...:    .||              :|.|:|||...||:||..
Human   437 YRPTDLFDELVA--HEVARMRADENH----PQR--------------VLRHVQELAEQLYKNENP 481

  Fly   521 LAHISYAQKVLRPPEGA-FQRIHQPAFPRISSEKVELIIQEGIRK-NGVPQRFHVTRNQHRIIPM 583
            ...:: ..||.||.|.: .:|:.:| |||:....|:.|:.:...| .|.|..  |...:...:|.
Human   482 YPAVA-MHKVQRPGESSHLRRVPRP-FPRLDEGTVQWIVDQAAAKMQGAPPA--VKAERRTTVPS 542

  Fly   584 GPRLPEALDVRPNVQ-NSARRLEVLRICVSYIFENRITDARKLLPAVMRTLMHRDARLILCREFF 647
            ||.:...|:....:. ||||||||:|.|:||:||.::.:|:||||||:|.|..|.||..|.:|..
Human   543 GPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELH 607

  Fly   648 GYVHGNKAVLDHQQFELVVRFMNKALQKSSGIDEYTVAAALLPMSTIFCRKLSTGVVQFAYTEIQ 712
            .:|..|:||||||||:.|||.||..||..:.:||:.:||||||:.|.||||||.||.||||:.:|
Human   608 LHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQ 672

  Fly   713 DHAIWKNLQFWESTFFQDVQGQIKALYLLHRRQNEHQKEANCVLDEVPLEEP--TALEITAEQLR 775
            :|.:|...||||:.|:.|||..|:||||.........:|    :.|.|.:|.  :||::.:||.|
Human   673 EHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQE----VGEAPSQEDERSALDVASEQRR 733

  Fly   776 KSPNIEEEKKAELAKSEESTLYSQAIHFANRMVSLLIPLDVNVDAASKPKPAF-RLE--ENQSVS 837
            ..|.:..||:.||.:.||||::|||||:||||..||:|||.:.....:.:... .||  .|..|:
Human   734 LWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVT 798

  Fly   838 NSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEGGVTSEHIRNLHDMVPGVVHMH 902
            ||:.||.:.|..::.|||:....::...|.:.|:||:|.||||.||||:|::.||.|||.:|.||
Human   799 NSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMH 863

  Fly   903 IESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDET------QCLIPAEG 961
            ||:||.|..|::|.|.:||||:..|.|||||:.|.|.||.:|:|||||:..      ..|:||||
Human   864 IETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGAGGSAGGPALLPAEG 928

  Fly   962 ALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQL 1026
            |:|||.|||||.|.|.|||..|||:||:||:|:|.|||:|||  ...:||.|.:||||||.:|||
Human   929 AVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISV--QTPVDQLLQDGLQLRSCTFQL 991

  Fly  1027 IKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKT 1091
            :|:|||.||..:..|.|||.|.|.|:|.|....|||........|..|..||:|..:|:..: :.
Human   992 LKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLS-RN 1055

  Fly  1092 LLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLT----TK 1152
            |::.|||...:|....|:.....:::......|.|  :||:...:|.|      |..||    .|
Human  1056 LVKNAKKTIGRQHVTRKKYNPPSWEHRGQPPPEDQ--EDEISVSEELE------PSTLTPSSALK 1112

  Fly  1153 DVERMR-----ERSYVQDWKRLGFDAES-------QRGFRISNANTSYATCRSYPAIIVAPVQCS 1205
            ..:||.     ||:..:|::|||....|       ...||||..|..||.|||||.:::.|....
Human  1113 PSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQ 1177

  Fly  1206 DAAIMHLGRCFKGQRIPLPTWRHANG-ALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQ 1269
            |.|:..:.||::..|.|:..||.... |:|:|.|..:.|.|:|:.|.....:.......:...||
Human  1178 DNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQ 1242

  Fly  1270 DKYFLALINTMPKLTPLA-LNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKS 1333
            :||..|::::||:....: .|..||.:   |:.||......|..:| .||    |.:..|...::
Human  1243 EKYLQAVVSSMPRYADASGRNTLSGFS---SAHMGSHVPSPRARVT-TLS----NPMAASASRRT 1299

  Fly  1334 SQGGKGGTMKGNPKNS---------------LAHP-----------FRKMR--LYALGEKSQAKS 1370
            :..||.|:::.:.::|               ||.|           .|..|  ||.||:|:|.|.
Human  1300 APRGKWGSVRTSGRSSGLGTDVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKG 1364

  Fly  1371 NMNVDFCA-DFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQ 1434
            ..:..... :.:|::..:.||.:.:||||::||:|.....|....||.:.:|.|:||.||..|:|
Human  1365 VRSDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQ 1429

  Fly  1435 LSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAH 1499
            :|..||:|:| ..|||::.||||.|:|.|:.|:.||..||:||:|:|||:|||||||:|||||:|
Human  1430 VSVLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSH 1493

  Fly  1500 RSNLKPSH--ANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDC 1562
            |.    :|  |..:..|.|.||||||.|||:..||||.|||:.|||:||.||.||.||||||.|.
Human  1494 RG----AHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDS 1554

  Fly  1563 ELERSDSGIAAME--DKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIF 1625
            :.||.:.|:...|  ::||.:..:                                      |::
Human  1555 DYERIELGLLYEEKGERRGQVPCR--------------------------------------SVW 1581

  Fly  1626 DYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWCYYTNEELAQGAPYDLEVT------TV 1684
            :|::|...:||:|:|::|:.:.:..|||.:||:.|.:|.:||.|.||:|.|||.|:.      ..
Human  1582 EYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPE 1646

  Fly  1685 DDEIDLSETKGKRMVITAGYDNMEKCNPSAYVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQ-L 1748
            ::..|....:.:|.|:...||:..:..|.|...||.|:::.|||.|...::|...|:.::..| |
Human  1647 EERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRL 1711

  Fly  1749 E--PVARNTSLGNIFVQTHQHKRSTLEIIMKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLL 1811
            |  |..|.|. .::.|.|..|.|.:|.:.::.
Human  1712 EGRPDGRGTP-SSLLVSTAPHHRRSLGVYLQE--------------------------------- 1742

  Fly  1812 WGPVGYRCMDCGNSYHEKCTEHSMKNCTKYKAIDGAVGPPNVNMSQGDTASIASSAATTARTSSH 1876
             ||||                     .|...::|.       :.|.|.|.|.:..|   ||.|:.
Human  1743 -GPVG---------------------STLSLSLDS-------DQSSGSTTSGSRQA---ARRSTS 1775

  Fly  1877 HFYNQFSSNVAENRTHEGHLYKRGALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQ 1941
            ..|:||.:..:|||::||.|||:||.:|.||.||||||..||||||||...||..||:|:||||:
Human  1776 TLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVE 1840

  Fly  1942 SVTAAQPAQIGAKGVDEKGFFDLKTSKRIYNFYAINANLAQEWIEKLQACL 1992
            :|....|.....|.||||.|||:||::|:|||.|.:...||:|::::|:||
Human  1841 AVAPGTPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCL 1891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824	50/89 (56%)
		DENN	142..325	CDD:460461	102/182 (56%)
		dDENN	384..452	CDD:129037	45/67 (67%)
		SBF2	584..807	CDD:463536	110/225 (49%)
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	67/119 (56%)
		PTP-MTMR5-like	1179..1531	CDD:350382	138/384 (36%)
		C1_Sbf-like	1790..1840	CDD:410377	4/49 (8%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	59/105 (56%)
SBF1	NP_001397723.1	uDENN	1..86	CDD:214824	50/90 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..123		7/38 (18%)
		DENN	130..311	CDD:214823	102/181 (56%)
		dDENN	365..433	CDD:129037	45/67 (67%)
		SBF2	543..765	CDD:463536	110/225 (49%)
		PH-like	894..1012	CDD:473070	67/119 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1116		12/56 (21%)
		PTP_DSP_cys	1151..1523	CDD:475123	138/384 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1632..1657		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1783		12/43 (28%)
		PH_Sbf1_hMTMR5	1787..1892	CDD:269941	59/105 (56%)