DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sbf and SBF1

DIOPT Version :9

Sequence 1:NP_477401.2 Gene:Sbf / 41427 FlyBaseID:FBgn0025802 Length:1993 Species:Drosophila melanogaster
Sequence 2:XP_011529011.1 Gene:SBF1 / 6305 HGNCID:10542 Length:1903 Species:Homo sapiens


Alignment Length:2036 Identity:830/2036 - (40%)
Similarity:1163/2036 - (57%) Gaps:243/2036 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 GKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSLSYEKQEPKFFVSVLTDIDANKHYCACLSFHETV 95
            |:|:||||||||.|.||.:|||.||||.||.|..|:..|.|||:|||||::.:||||||:|.|..
Human    34 GQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPA 98

  Fly    96 AITQTRSVDDEDETIGSSRLLGATPSSMDGITTTSTPASITHHSVMYAPKCLVLISRLDCAETFK 160
            ..:|..:...||.|       .......:|..|..:|.:....:.::|||.|||:||||..|.|:
Human    99 EPSQQETTRVEDAT-------EREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHTEVFR 156

  Fly   161 NCLGTIYTVYIENLAYGLETLIGNILGCIQVPPAGGPQVRFSIGAGDKQSLQPPQSSSLPTTGSG 225
            |.||.||.:::|.|...||.:|||:|.| .||.|||.|...|:||||:|.:|.|.:.|||.:...
Human   157 NSLGLIYAIHVEGLNVCLENVIGNLLTC-TVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCS 220

  Fly   226 VHFLFKQLGIKNVLILLCSVMTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLT 290
            |..||:||||.|||.|.|:.:||:|:||||:.|..|.|:||.|:||::|.||:..|:|||||.|.
Human   221 VALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLL 285

  Fly   291 EVLSTPTPFIMGIHSSLQTEITDLLDVIVVDLDGGLVTIPESLTPPVPILPSPLWEQTQDLLSMI 355
            ||||||||||:|::::.|.|..:||||||.|||||.|||||.:  .:|.||.||..||..:|||:
Human   286 EVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTIPECV--HIPPLPEPLQSQTHSVLSMV 348

  Fly   356 LFPNLAQADLAFPTLERPSAIAKTDAQIDKELRAIFMRLFAQLLQGYRSCLTIIRIHPKPVITFH 420
            |.|.|..||||||.   |:....:....||||||:|:|||||||||||.||.::||||:|||.||
Human   349 LDPELELADLAFPP---PTTSTSSLKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFH 410

  Fly   421 KAGFLGARDLIESEFLFRVLDSMFFTTFVNERGPPWRSSDAWDELYSSMNELLKSEAQNRNLVGR 485
            ||.|||.|.|:|.:||.:||:.|.|..||:|||.|:|.:|.:|||.:  :|:.:..|...:    
Human   411 KAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVPYRPTDLFDELVA--HEVARMRADENH---- 469

  Fly   486 TQRFKGYFNFTFPSYFQILTHIQELGRVLYENEGTLAHISYAQKVLRPPEGA-FQRIHQPAFPRI 549
            .||              :|.|:|||...||:||.....:: ..||.||.|.: .:|:.:| |||:
Human   470 PQR--------------VLRHVQELAEQLYKNENPYPAVA-MHKVQRPGESSHLRRVPRP-FPRL 518

  Fly   550 SSEKVELIIQEGIRK-NGVPQRFHVTRNQHRIIPMGPRLPEALDVRPNVQ-NSARRLEVLRICVS 612
            ....|:.|:.:...| .|.|..  |...:...:|.||.:...|:....:. ||||||||:|.|:|
Human   519 DEGTVQWIVDQAAAKMQGAPPA--VKAERRTTVPSGPPMTAILERCSGLHVNSARRLEVVRNCIS 581

  Fly   613 YIFENRITDARKLLPAVMRTLMHRDARLILCREFFGYVHGNKAVLDHQQFELVVRFMNKALQKSS 677
            |:||.::.:|:||||||:|.|..|.||..|.:|...:|..|:||||||||:.|||.||..||..:
Human   582 YVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCT 646

  Fly   678 GIDEYTVAAALLPMSTIFCRKLSTGVVQFAYTEIQDHAIWKNLQFWESTFFQDVQGQIKALYLLH 742
            .:||:.:||||||:.|.||||||.||.||||:.:|:|.:|...||||:.|:.|||..|:||||..
Human   647 SLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEP 711

  Fly   743 RRQNEHQKEANCVLDEVPLEEP--TALEITAEQLRKSPNIEEEKKAELAKSEESTLYSQAIHFAN 805
            .......:|    :.|.|.:|.  :||::.:||.|..|.:..||:.||.:.||||::|||||:||
Human   712 TEDLAPAQE----VGEAPSQEDERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYAN 772

  Fly   806 RMVSLLIPLDVNVDAASKPKPAF-RLE--ENQSVSNSIMGSHSLSEHSDEGFEENNALEIGVTVG 867
            ||..||:|||.:.....:.:... .||  .|..|:||:.||.:.|..::.|||:....::...|.
Human   773 RMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVV 837

  Fly   868 KTISRFIDCVCTEGGVTSEHIRNLHDMVPGVVHMHIESLEPVYLEAKRHPHVQKPKIQTPCLLPG 932
            :.|:||:|.||||.||||:|::.||.|||.:|.||||:||.|..|::|.|.:||||:..|.||||
Human   838 RFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPG 902

  Fly   933 EDLVTDHLRCFLMPDGREDET------QCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFP 991
            |:.|.|.||.:|:|||||:..      ..|:|||||:|||.|||||.|.|.|||..|||:||:||
Human   903 EECVLDGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFP 967

  Fly   992 IASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDE 1056
            :|:|.|||:|||  ...:||.|.:||||||.:|||:|:|||.||..:..|.|||.|.|.|:|.|.
Human   968 VAALTKEKRISV--QTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDI 1030

  Fly  1057 FEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSAD 1121
            ...|||........|..|..||:|..:|:..: :.|::.|||...:|....|:.....:::....
Human  1031 RATFAFTLGSAHTPGRPPRVTKDKGPSLRTLS-RNLVKNAKKTIGRQHVTRKKYNPPSWEHRGQP 1094

  Fly  1122 AQETQSIDDELEDGDEFETQNNAMPRLLT----TKDVERMR-----ERSYVQDWKRLGFDAES-- 1175
            ..|.|  :||:...:|.|      |..||    .|..:||.     ||:..:|::|||....|  
Human  1095 PPEDQ--EDEISVSEELE------PSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSS 1151

  Fly  1176 -----QRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG-ALL 1234
                 ...||||..|..||.|||||.:::.|....|.|:..:.||::..|.|:..||.... |:|
Human  1152 LSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVL 1216

  Fly  1235 IRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLA-LNQYSGMNLSM 1298
            :|.|..:.|.|:|:.|.....:.......:...||:||..|::::||:....: .|..||.:   
Human  1217 LRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFS--- 1278

  Fly  1299 SSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNS-------------- 1349
            |:.||......|..:| .||    |.:..|...:::..||.|:::.:.::|              
Human  1279 SAHMGSHVPSPRARVT-TLS----NPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRD 1338

  Fly  1350 -LAHP-----------FRKMR--LYALGEKSQAKSNMNVDFCA-DFIPVDYPDIRQSRPAFKKLI 1399
             ||.|           .|..|  ||.||:|:|.|...:..... :.:|::..:.||.:.:||||:
Human  1339 ALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVFEARQVKASFKKLL 1403

  Fly  1400 RACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQL 1464
            :||:|.....|....||.:.:|.|:||.||..|:|:|..||:|:| ..|||::.||||.|:|.|:
Human  1404 KACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLD-SGSSVLVGLEDGWDITTQV 1467

  Fly  1465 SSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSH--ANTNIAFAPTFLQFLDVVHQ 1527
            .|:.||..||:||:|:|||:|||||||:|||||:||.    :|  |..:..|.|.||||||.|||
Human  1468 VSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRG----AHTLAGQSSGFTPVFLQFLDCVHQ 1528

  Fly  1528 LQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAME--DKRGSLNAKHMFGAG 1590
            :..||||.|||:.|||:||.||.||.||||||.|.:.||.:.|:...|  ::||.:..:      
Human  1529 VHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCR------ 1587

  Fly  1591 GMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQN 1655
                                            |:::|::|...:||:|:|::|:.:.:..|||.:
Human  1588 --------------------------------SVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYS 1620

  Fly  1656 NVAALDLWCYYTNEELAQGAPYDLEVT------TVDDEIDLSETKGKRMVITAGYDNMEKCNPSA 1714
            ||:.|.:|.:||.|.||:|.|||.|:.      ..::..|....:.:|.|:...||:..:..|.|
Human  1621 NVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDA 1685

  Fly  1715 YVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQ-LE--PVARNTSLGNIFVQTHQHKRSTLEIIM 1776
            ...||.|:::.|||.|...::|...|:.::..| ||  |..|.|. .::.|.|..|.|.:|.:.:
Human  1686 ISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTP-SSLLVSTAPHHRRSLGVYL 1749

  Fly  1777 KGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEKCTEHSMKNCTKY 1841
            :.                                  ||||                     .|..
Human  1750 QE----------------------------------GPVG---------------------STLS 1759

  Fly  1842 KAIDGAVGPPNVNMSQGDTASIASSAATTARTSSHHFYNQFSSNVAENRTHEGHLYKRGALLKGW 1906
            .::|.       :.|.|.|.|.:..|   ||.|:...|:||.:..:|||::||.|||:||.:|.|
Human  1760 LSLDS-------DQSSGSTTSGSRQA---ARRSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPW 1814

  Fly  1907 KQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGAKGVDEKGFFDLKTSKRIY 1971
            |.||||||..||||||||...||..||:|:||||::|....|.....|.||||.|||:||::|:|
Human  1815 KARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRRVY 1879

  Fly  1972 NFYAINANLAQEWIEKLQACL 1992
            ||.|.:...||:|::::|:||
Human  1880 NFCAQDVPSAQQWVDRIQSCL 1900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SbfNP_477401.2 uDENN 1..91 CDD:214824 39/59 (66%)
DENN 142..325 CDD:280329 102/182 (56%)
dDENN 384..452 CDD:129037 45/67 (67%)
SBF2 585..807 CDD:289132 109/224 (49%)
PH-GRAM_MTMR5_MTMR13 933..1047 CDD:275396 67/119 (56%)
Myotub-related 1161..1565 CDD:284109 166/443 (37%)
C1 1791..1838 CDD:237996 4/46 (9%)
PH_Sbf1_hMTMR5 1888..1993 CDD:269941 59/105 (56%)
PH 1891..1992 CDD:278594 54/100 (54%)
SBF1XP_011529011.1 uDENN 36..92 CDD:281455 36/55 (65%)
DENN 139..320 CDD:214823 102/181 (56%)
dDENN 374..442 CDD:129037 45/67 (67%)
SBF2 553..774 CDD:289132 109/224 (49%)
PH-GRAM_MTMR5 903..1021 CDD:275417 67/119 (56%)
Myotub-related 1138..1566 CDD:284109 166/440 (38%)
PH_Sbf1_hMTMR5 1796..1901 CDD:269941 59/105 (56%)
PH 1800..1901 CDD:278594 56/101 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155602
Domainoid 1 1.000 268 1.000 Domainoid score I1872
eggNOG 1 0.900 - - E1_KOG1090
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1430 1.000 Inparanoid score I116
Isobase 1 0.950 - 0 Normalized mean entropy S4814
OMA 1 1.010 - - QHG45747
OrthoDB 1 1.010 - - D11535at33208
OrthoFinder 1 1.000 - - FOG0003022
OrthoInspector 1 1.000 - - otm41955
orthoMCL 1 0.900 - - OOG6_104786
Panther 1 1.100 - - LDO PTHR10807
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8681
SonicParanoid 1 1.000 - - X2012
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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