DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtmr10

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_005168938.1	Gene:	mtmr10 / 555239	ZFINID:	ZDB-GENE-061103-52	Length:	765	Species:	Danio rerio

Alignment Length:	892	Identity:	198/892 - (22%)
Similarity:	309/892 - (34%)	Gaps:	302/892 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   906 LEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDH---LRCFLMPDGREDETQCLIPAEGALFLTN 967
            |.|:..:.|:.|.:...|::.. |||||.:|.:.   .:|.....|::|       ..|.|..||
Zfish    15 LPPLQTDLKKSPQLPIKKLEAK-LLPGEIVVNEANFVRKCIGADSGQDD-------LWGKLVCTN 71

  Fly   968 YRVIF-----------------KGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTL-- 1013
            ::|.|                 .|....||.|.:.:|....:..  |:|      :...:|.|
Zfish    72 FKVSFISHNSLPQQRFQCTHRLLGEHDIPLACVEQVVTVNDVKG--KQK------ILGSNQKLKF 128

  Fly  1014 --TEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLK 1076
              || |.|....|::|:..|| |..||..:.....::...||.|....|.|:..|
Zfish   129 NPTE-LILYCKDFRIIRFRFD-EAGPESAKKVCLAIAHYSHPADPQLLFGFEYVG---------- 181

  Fly  1077 TKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQ 1141
              ::|                                   :||| .:....:|    .|...:|
Zfish   182 --KRY-----------------------------------HGSA-GERVNGVD----PGGGLQT- 203

  Fly  1142 NNAMPRLLTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSD 1206
                |....:.|.:|..:|:...:|             |:...|..|....|.|...|.||..:|
Zfish   204 ----PLFDCSSDWDREIKRTGASEW-------------RVCTINQGYFISPSLPEFFVVPVSLAD 251

  Fly  1207 AAIMHLGRCFKGQRIPLPTWRHANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDK 1271
            ..:.....||..|||||..|.|..|:.|:|
Zfish   252 QDLKQYACCFYSQRIPLWCWNHPCGSALVR----------------------------------- 281

  Fly  1272 YFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQG 1336
                                      ||::     ||      |:..||.:..:       ||..
Zfish   282 --------------------------MSNI-----SD------PQQQRKVEQRI-------SSAI 302

  Fly  1337 GKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRA 1401
            .|            :||.|....     ||....|:             |:|:..:.|..||.:.
Zfish   303 TK------------SHPLRSDVF-----KSDLDKNL-------------PNIQDIQAALLKLRQI 337

  Fly  1402 CMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSS 1466
            |:  ..:.|...:.:...:|.|.|::.:.:.::.:..||.:::.:..||:|..::..|::..:||
Zfish   338 CV--IESFEESEEKWLSSLESSRWMEYVRTFLRHAVEVVYMLESRHVSVILLEKEDRDLSCVISS 400

  Fly  1467 IAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSN-LKPSHANTNIAFAPTFLQFLDVVHQLQR 1530
            :.||..||:.|||.||:.|::|||:..||||..|.| ||.|....    :|.||.|||.|.||..
Zfish   401 LVQLMCDPHCRSLHGFQALIQKEWVMAGHRFLDRCNHLKKSDKEE----SPLFLLFLDCVWQLWN 461

  Fly  1531 QFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELER--------SDSGIAAMED----------- 1576
            |:|.||||.:.||..|........|.||||:|..:|        |...|...:|
Zfish   462 QYPAAFEFTEVYLTVLGDSMWVPVFSTFLFNCPRQRAEHSRDFASSKSIHLGQDQALRFPPVWDW 526

  Fly  1577 -KRGSLNAKHMFG----AGGMAT-------------------------------NGSDDECSVYP 1605
             ::.||..:.:|.    .|.:||                               ||     |:.|
Zfish   527 SQQFSLKDQTLFNNPLYVGKIATCLQNGTVKTFTHRRSKKNYSSTVRGLPSLMRNG-----SLGP 586

  Fly  1606 LDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSG--DKSVTLRPQNNVAALDLWCYY-- 1666
            .|..::|....| |:...:....|:....:..|....:|.  |....|.||...:.|.:|..|
Zfish   587 NDTLTRRNSLVL-RLRSDLSQVREQPETPSERFVRDFFSRAVDLQGLLLPQLLPSHLSVWKLYFL 650

  Fly  1667 ---TNEELAQGAP----YDLEVTTVDDEIDLSETKGKRMVITAGYDN 1706
               ...::..|.|    :.|.|.|  |||::.:.:.::....||..|
Zfish   651 RWVPEAQIPHGGPVTAFHKLSVLT--DEIEMLQNQLRQYKGAAGTAN 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	31/137 (23%)
		Myotub-related	1161..1565	CDD:284109	102/404 (25%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtmr10	XP_005168938.1	PH-GRAM_MTMR10	20..196	CDD:270154	48/241 (20%)
		PTPc	208..496	CDD:304379	105/415 (25%)
		3-PAP	566..689	CDD:289355	26/130 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840