DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtmr1a

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_009301334.1	Gene:	mtmr1a / 553750	ZFINID:	ZDB-GENE-050522-518	Length:	699	Species:	Danio rerio

Alignment Length:	805	Identity:	184/805 - (22%)
Similarity:	301/805 - (37%)	Gaps:	225/805 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   912 EAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSP 976
            :.:.||...:..:..|......:|..:       |..|:|....|....|:
Zfish     4 QQQHHPSGSESPVLPPVARKPRNLGVN-------PASRQDSVDSLDSPTGS-------------- 47

  Fly   977 CDPLFCEQVIVRTF--------PIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDP 1033
             ...:|:|:|..|.        |..|:.:|.||.    ..:|..:::....||.........||.
Zfish    48 -HVEWCKQLIAATISSQITSGVPSESIHRESKIG----KKIDTRVSKRPNFRSQDSGEDGCQFDS 107

  Fly  1034 --EVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGA 1096
              |:.....:.||.:...|  |.||......::..|.::.|..:      ....|....||....
Zfish   108 DCELPSHTSQVFRDVRRPA--PMDEVPLVPGETIKTTVKDVMYI------CPFTGAVTGTLTITD 164

  Fly  1097 KKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDD--ELEDGDEFETQNNAMPRLLTTKD------ 1153
            .|..|...:: ....:.|.:.|:....||.|:..  |...|.|...::...||....|:
Zfish   165 YKLYFVSLER-DAPFILDVNLGAISRLETISVQSLGENTSGMEIVCKDMRSPRFAYKKEEQSKLE 228

  Fly  1154 -VERMRERSY---------------------------VQDWKRLGFDAESQRGFRISNANTSYAT 1190
             :|.:.:.::                           |.::||:|...||   :.||..|::|..
Zfish   229 ILETLTKYAFPLSNELSLFAFQYKEQFPEDGWKVYDPVAEYKRMGLPNES---WSISKINSNYEV 290

  Fly  1191 CRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQPNSKSVIGMLKNTTG 1254
            |.:|||::|.|....:..|..:.......|||:.:|.| ...|.::|..||           ..|
Zfish   291 CDTYPALLVTPTSIKEDEIRRVASFRVKHRIPVLSWIHPETQATIVRCSQP-----------MVG 344

  Fly  1255 STTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSR 1319
            .|.....:..||                               :.::|..:            ::
Zfish   345 PTDRRCKEDEHY-------------------------------LQTIMDAN------------AQ 366

  Fly  1320 KHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVD 1384
            .||  |.|.|..:::......|..|..:|...:|                 ||.::|      ::
Zfish   367 SHK--LAIFDARQNTVAHNHKTKDGGYENENFYP-----------------NMELNF------LE 406

  Fly  1385 YPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAV--VDLIDLQE 1447
            .|:|...|.:.:||.....|:     .:.|.:...::.:.||:.|..|  |:|||  .|.::..:
Zfish   407 IPNIHVMRESLRKLKEVVYPT-----IEEQRWHSAIDATHWLEYIRLL--LAGAVRIADKVESSK 464

  Fly  1448 SSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHR-SNLKPSHANTN 1511
            |||::...||.|.||||:|::.|.||.|||:|.||:||:||||::|||:||.| .:...:|||:.
Zfish   465 SSVVVHCSDGWDRTAQLTSLSMLMLDSYYRTLRGFQVLLEKEWISFGHKFAARIGHGDENHANSE 529

  Fly  1512 IAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMED 1576
              .:|.|:||:|.|.|:.||||.|||||:.:|..:..:..||.|.|||::.|.||.:..:
Zfish   530 --RSPLFVQFIDCVWQMMRQFPSAFEFNELFLITILDYLYSCLFGTFLYNSEQERVEKEV----- 587

  Fly  1577 KRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNF 1641
                                                     ||...|::.||..|...   |.|.
Zfish   588 -----------------------------------------NRKTVSLWSYINSQSED---FTNP 608

  Fly  1642 LYSGDKSVTLRPQNNVAALDLWCYY 1666
            .|...::..|.|..::..|:||..|
Zfish   609 FYVDYENHVLYPLASLRHLELWVGY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	23/123 (19%)
		Myotub-related	1161..1565	CDD:284109	118/434 (27%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtmr1a	XP_009301334.1	PH-GRAM_MTMR1	140..239	CDD:270165	19/105 (18%)
mtmr1a	XP_009301334.1	Myotub-related	246..581	CDD:284109	118/425 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840