DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and MTMR10

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_060232.2	Gene:	MTMR10 / 54893	HGNCID:	25999	Length:	777	Species:	Homo sapiens

Alignment Length:	676	Identity:	151/676 - (22%)
Similarity:	252/676 - (37%)	Gaps:	222/676 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   921 KPKIQ--TPCLLPGEDLVTD---HLRCFLMPDGREDETQCLIPAEGAL-FLT---------NYRV 970
            :|||:  .|.|||||.:|.:   ..:|......:.|....||.:...: |:|         :||.
Human    28 EPKIKKLEPVLLPGEIVVNEVNFVRKCIATDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRN 92

  Fly   971 IFKGSPCDPLFC-EQVIVRTFPIASLLKEKKISVLYLAHLDQTL----TEGLQLRSSSFQLIKVA 1030
            :..|....||.| ||::.    :....:::|:     ...:|.|    || |.:....|::::..
Human    93 LLLGEHDVPLTCIEQIVT----VNDHKRKQKV-----LGPNQKLKFNPTE-LIIYCKDFRIVRFR 147

  Fly  1031 FDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKY----STLKGFAKKT 1091
            || |..||..:.....::....|.|....|||:..|            :||    :.:.|.....
Human   148 FD-ESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVG------------KKYHNSANKINGIPSGD 199

  Fly  1092 LLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVER 1156
               |....|            .....|...:|:|..          |||.:
Human   200 ---GGGGGG------------GGNGAGGGSSQKTPL----------FETYS-------------- 225

  Fly  1157 MRERSYVQDWKRLGFDAESQR----GFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFK 1217
                    ||     |.|.:|    |:|:.:.|..|......|..||.|...:|..:......|.
Human   226 --------DW-----DREIKRTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFV 277

  Fly  1218 GQRIPLPTWRHANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPK 1282
            |:|:||..|.|:||:.|:|         :.::|:..              :|.|....:.|.:.|
Human   278 GRRMPLWCWSHSNGSALVR---------MALIKDVL--------------QQRKIDQRICNAITK 319

  Fly  1283 LTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPK 1347
                                .|          |:.|..:|::||.:
Human   320 --------------------SH----------PQRSDVYKSDLDKT------------------- 335

  Fly  1348 NSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACM--PSHNTNE 1410
                                                 .|:|::.:.||.||.:.|:  |...|.|
Human   336 -------------------------------------LPNIQEVQAAFVKLKQLCVNEPFEETEE 363

  Fly  1411 ADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPY 1475
                .:...:|.:.||:.:.:.::.|..:|.:::.:..||:|..|:|.|::..::|:.|:.||||
Human   364 ----KWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPY 424

  Fly  1476 YRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFND 1540
            :|::.||:.|::|||:..|::|..|.|    |...:...:|.||.|||...||..|:|.||||::
Human   425 FRTITGFQSLIQKEWVMAGYQFLDRCN----HLKRSEKESPLFLLFLDATWQLLEQYPAAFEFSE 485

  Fly  1541 FYLRFLAYHSVSCRFRTFLFDCELER 1566
            .||..|...:....|.||||:...:|
Human   486 TYLAVLYDSTRISLFGTFLFNSPHQR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	28/131 (21%)
		Myotub-related	1161..1565	CDD:284109	97/409 (24%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
MTMR10	NP_060232.2	PH-GRAM_MTMR10	21..195	CDD:270154	44/189 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..217		3/35 (9%)
		Myotub-related	226..507	CDD:284109	97/402 (24%)
		3-PAP	578..705	CDD:289355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155599
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840