Protein Alignment Sbf and Mtmr1

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: XP_036017901.1
• Gene: Mtmr1 / 53332
• MGIID: 1858271
• Length: 704
• Species: Mus musculus
• Alignment Length: 855
• Identity: 201/855 - (23%)
• Similarity: 308/855 - (36%)
• Gaps: 331/855 - (38%)

  Fly   862 IGVTVGKTISRFIDCVCTEGGVTSEHI------------RNLHDMVPGVVHMHIESLEPVYLEAK 914
            |..|:...||         |.||||::            ||:|           ::.:.:.||.:
Mouse    66 IAATISSQIS---------GSVTSENVSRDYKVFRRPDTRNIH-----------KARQRLELEEE 110

  Fly   915 RHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAE------------------- 960
            .:.:..:.:.....|..|..|.             :.|...|.|.|
Mouse   111 HNGYPSEAEADQVALRDGNKLA-------------QMEEAPLFPGESIKAIVKDVIYICPFMGAV 162

  Fly   961 -GALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSF 1024
             |.|.:|::::.||....||.|     |...|:..:.:.:||..  .:|.|.:.  |:::.....
Mouse   163 SGTLTVTDFKMYFKNVERDPHF-----VLDVPLGVISRVEKIGA--QSHGDNSC--GIEIVCKDM 218

  Fly  1025 QLIKVAFDPEVTPEQIESFRKI-----LSKARHPFDEFE-YFAFQSYGTMLQGVAPLKTKEKYST 1083
            :.:::|:..|   ||    ||:     |:|...|....: .||| :|            |||:..
Mouse   219 RNLRLAYKQE---EQ----RKLGIFENLNKHAFPLSNGQVLFAF-NY------------KEKFPV 263

  Fly  1084 LKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRL 1148
                           .|:|.           ||                             |
Mouse   264 ---------------NGWKV-----------YD-----------------------------P-- 271

  Fly  1149 LTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLG 1213
                          |.::||.|...||   ::||..|::|..|.:||||||.|....|..:..:.
Mouse   272 --------------VSEYKRQGLPNES---WKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVA 319

  Fly  1214 RCFKGQRIPLPTWRHANG-ALLIRGGQ----PNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYF 1273
            ......|:|:.:|.|... |.:.|..|    ||.|                     ...|.:||.
Mouse   320 AFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDK---------------------RCKEDEKYL 363

  Fly  1274 LALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGK 1338
            ..:::...:...|.:                  .|.||.             .::|.||:..||.
Mouse   364 QTIMDANAQSHKLTI------------------FDARQN-------------SVADTNKAKGGGY 397

  Fly  1339 GGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACM 1403
                    :|..|:|                       .|:.|.::..:|...|.:.:||.....
Mouse   398 --------ENESAYP-----------------------NAELIFLEIHNIHVMRESLRKLKEIVY 431

  Fly  1404 PSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAV--VDLIDLQESSVMLSLEDGSDVTAQLSS 1466
            ||     .|...:...|:.:.||:.|..|  |:|||  .|.|:..::||::...||.|.|:||:|
Mouse   432 PS-----IDESHWLSNVDGTHWLEYIRVL--LAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTS 489

  Fly  1467 IAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFA---PTFLQFLDVVHQL 1528
            :|.|.||.|||::.||..|:||||::||||||    |:..|.:.|.|.|   |.||||:|.|.|:
Mouse   490 LAMLMLDSYYRTIKGFEALIEKEWISFGHRFA----LRVGHGDDNHADADRSPIFLQFIDCVWQM 550

  Fly  1529 QRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMA 1593
            .||||.|||||:.:|..:..|..||.|.|||.:||.:|      ..||
Mouse   551 TRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQR------IKED----------------- 592

  Fly  1594 TNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNK--TPIFYNFLYSGDKSVTLRPQNN 1656
                     ||...|              |::.||..|.::  .|.|.|:     ::..|.|..:
Mouse   593 ---------VYTNTI--------------SLWSYINSQLDEFSNPFFVNY-----ENHVLYPVAS 629

  Fly  1657 VAALDLWCYY 1666
            ::.|:||..|
Mouse   630 MSHLELWVNY 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:460461
		dDENN	384..452	CDD:129037
		SBF2	584..807	CDD:463536
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	26/138 (19%)
		PTP-MTMR5-like	1179..1531	CDD:350382	100/361 (28%)
		C1_Sbf-like	1790..1840	CDD:410377
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
Mtmr1	XP_036017901.1	PH-GRAM_MTMR1	146..245	CDD:270165	23/114 (20%)
		Myotub-related	262..588	CDD:461958	130/493 (26%)