DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr1

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_036017901.1	Gene:	Mtmr1 / 53332	MGIID:	1858271	Length:	704	Species:	Mus musculus

Alignment Length:	855	Identity:	201/855 - (23%)
Similarity:	308/855 - (36%)	Gaps:	331/855 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   862 IGVTVGKTISRFIDCVCTEGGVTSEHI------------RNLHDMVPGVVHMHIESLEPVYLEAK 914
            |..|:...||         |.||||::            ||:|           ::.:.:.||.:
Mouse    66 IAATISSQIS---------GSVTSENVSRDYKVFRRPDTRNIH-----------KARQRLELEEE 110

  Fly   915 RHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAE------------------- 960
            .:.:..:.:.....|..|..|.             :.|...|.|.|
Mouse   111 HNGYPSEAEADQVALRDGNKLA-------------QMEEAPLFPGESIKAIVKDVIYICPFMGAV 162

  Fly   961 -GALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSF 1024
             |.|.:|::::.||....||.|     |...|:..:.:.:||..  .:|.|.:.  |:::.....
Mouse   163 SGTLTVTDFKMYFKNVERDPHF-----VLDVPLGVISRVEKIGA--QSHGDNSC--GIEIVCKDM 218

  Fly  1025 QLIKVAFDPEVTPEQIESFRKI-----LSKARHPFDEFE-YFAFQSYGTMLQGVAPLKTKEKYST 1083
            :.:::|:..|   ||    ||:     |:|...|....: .||| :|            |||:..
Mouse   219 RNLRLAYKQE---EQ----RKLGIFENLNKHAFPLSNGQVLFAF-NY------------KEKFPV 263

  Fly  1084 LKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRL 1148
                           .|:|.           ||                             |
Mouse   264 ---------------NGWKV-----------YD-----------------------------P-- 271

  Fly  1149 LTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLG 1213
                          |.::||.|...||   ::||..|::|..|.:||||||.|....|..:..:.
Mouse   272 --------------VSEYKRQGLPNES---WKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVA 319

  Fly  1214 RCFKGQRIPLPTWRHANG-ALLIRGGQ----PNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYF 1273
            ......|:|:.:|.|... |.:.|..|    ||.|                     ...|.:||.
Mouse   320 AFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDK---------------------RCKEDEKYL 363

  Fly  1274 LALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGK 1338
            ..:::...:...|.:                  .|.||.             .::|.||:..||.
Mouse   364 QTIMDANAQSHKLTI------------------FDARQN-------------SVADTNKAKGGGY 397

  Fly  1339 GGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACM 1403
                    :|..|:|                       .|:.|.::..:|...|.:.:||.....
Mouse   398 --------ENESAYP-----------------------NAELIFLEIHNIHVMRESLRKLKEIVY 431

  Fly  1404 PSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAV--VDLIDLQESSVMLSLEDGSDVTAQLSS 1466
            ||     .|...:...|:.:.||:.|..|  |:|||  .|.|:..::||::...||.|.|:||:|
Mouse   432 PS-----IDESHWLSNVDGTHWLEYIRVL--LAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTS 489

  Fly  1467 IAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFA---PTFLQFLDVVHQL 1528
            :|.|.||.|||::.||..|:||||::||||||    |:..|.:.|.|.|   |.||||:|.|.|:
Mouse   490 LAMLMLDSYYRTIKGFEALIEKEWISFGHRFA----LRVGHGDDNHADADRSPIFLQFIDCVWQM 550

  Fly  1529 QRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMA 1593
            .||||.|||||:.:|..:..|..||.|.|||.:||.:|      ..||
Mouse   551 TRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQR------IKED----------------- 592

  Fly  1594 TNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNK--TPIFYNFLYSGDKSVTLRPQNN 1656
                     ||...|              |::.||..|.::  .|.|.|:     ::..|.|..:
Mouse   593 ---------VYTNTI--------------SLWSYINSQLDEFSNPFFVNY-----ENHVLYPVAS 629

  Fly  1657 VAALDLWCYY 1666
            ::.|:||..|
Mouse   630 MSHLELWVNY 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	26/138 (19%)
		Myotub-related	1161..1565	CDD:284109	125/413 (30%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr1	XP_036017901.1	PH-GRAM_MTMR1	146..245	CDD:270165	23/114 (20%)
Mtmr1	XP_036017901.1	Myotub-related	262..588	CDD:399535	130/493 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910