Protein Alignment Sbf and MTM1

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: XP_047298088.1
• Gene: MTM1 / 4534
• HGNCID: 7448
• Length: 625
• Species: Homo sapiens
• Alignment Length: 967
• Identity: 212/967 - (21%)
• Similarity: 336/967 - (34%)
• Gaps: 376/967 - (38%)

  Fly   829 RLEENQSVSNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEGGVTSEHIRNLHD 893
            |:....|.|.|...||||         ||.::       |..||        .||.    |:|.:
Human     4 RVSRMASASTSKYNSHSL---------ENESI-------KRTSR--------DGVN----RDLTE 40

  Fly   894 MVPGVVHMHIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMP-DGREDETQCLI 957
            .||                                .||||.|:||....::.| :|
Human    41 AVP--------------------------------RLPGETLITDKEVIYICPFNG--------- 64

  Fly   958 PAEGALFLTNYRVI------------FKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLD 1010
            |.:|.:::||||:.            |:...|  ||.:..::...|:..:.:.:|:.
Human    65 PIKGRVYITNYRLYLRSLETLSSHWRFEVDTC--LFQDSSLILDVPLGVISRIEKMG-------- 119

  Fly  1011 QTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHP-FDEFEYFAFQSYGTMLQGVAP 1074
                 |...|..:      ::..::|.:.:.:.|..|.:..|. .|.||...  .|...|....|
Human   120 -----GATSRGEN------SYGLDITCKDMRNLRFALKQEGHSRRDMFEILT--RYAFPLAHSLP 171

  Fly  1075 LKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFE 1139
            |           ||                                      .:::|..:.|.:.
Human   172 L-----------FA--------------------------------------FLNEEKFNVDGWT 187

  Fly  1140 TQNNAMPRLLTTKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQC 1204
            ..|.                   |::::|.|.   ....:||:..|..|..|.:|||::|.|.:.
Human   188 VYNP-------------------VEEYRRQGL---PNHHWRITFINKCYELCDTYPALLVVPYRA 230

  Fly  1205 SDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPE 1268
            ||..:..:.......|||:.:|.| .|..:::|..||    ::||    :|....         :
Human   231 SDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQP----LVGM----SGKRNK---------D 278

  Fly  1269 QDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKS 1333
            .:||...:..|..:::.|.:.                   |.:|....::            ||:
Human   279 DEKYLDVIRETNKQISKLTIY-------------------DARPSVNAVA------------NKA 312

  Fly  1334 SQGGKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKL 1398
            :.||.                         |...|..|..:.|      :|..:|...|.:.||:
Human   313 TGGGY-------------------------ESDDAYHNAELFF------LDIHNIHVMRESLKKV 346

  Fly  1399 IRACMPSHNTNEADGQSFAKMVEQSDWLQQISSL-------MQLSGA--VVDLIDLQESSVMLSL 1454
            .....|:              ||:|.||..:.|.       :.|:||  |.|.:...:|||::..
Human   347 KDIVYPN--------------VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHC 397

  Fly  1455 EDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFA---P 1516
            .||.|.||||:|:|.|.||.:|||::||.:||:|||::|||:||.|.    .|.:.|...|   |
Human   398 SDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRI----GHGDKNHTDADRSP 458

  Fly  1517 TFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSL 1581
            .||||:|.|.|:.:|||.|||||:.:|..:..|..||||.||||:||..|....:.
Human   459 IFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVT--------- 514

  Fly  1582 NAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGD 1646
                              |.:|                   |::..|.....|   |.|..|:.:
Human   515 ------------------ERTV-------------------SLWSLINSNKEK---FKNPFYTKE 539

  Fly  1647 KSVTLRPQNNVAALDLWC-YYT--NEELAQGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNME 1708
            .:..|.|..::..|:||. ||.  |..:.|..|..:|              .:.|.:.|..|.
Human   540 INRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVE--------------QRYMELLALRDE-- 588

  Fly  1709 KCNPSAYVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQLEPVARNTSLGNIFVQTH 1765
                  |:..|.|::.|.:.:             |..|...|.:.:..:.:  ||||
Human   589 ------YIKRLEELQLANSAK-------------LSDPPTSPSSPSQMMPH--VQTH 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:460461
		dDENN	384..452	CDD:129037
		SBF2	584..807	CDD:463536
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	22/126 (17%)
		PTP-MTMR5-like	1179..1531	CDD:350382	97/364 (27%)
		C1_Sbf-like	1790..1840	CDD:410377
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
MTM1	XP_047298088.1	PH-like	51..165	CDD:473070	26/145 (18%)
		Myotub-related	184..511	CDD:461958	123/445 (28%)