DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtmr3

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_021333893.1	Gene:	mtmr3 / 393838	ZFINID:	ZDB-GENE-091204-465	Length:	1186	Species:	Danio rerio

Alignment Length:	879	Identity:	218/879 - (24%)
Similarity:	334/879 - (37%)	Gaps:	266/879 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   903 IESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAEGALF-LT 966
            :|.::...:..::.|.:::..:|.|                 .|:...:.|:.:..||.|:. ::
Zfish     9 LECIQANQIFPRKPPVLEEEDLQVP-----------------FPELHGEFTEYVGRAEDAVIAMS 56

  Fly   967 NYR--VIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKV 1029
            :||  :.||.|..:...||                 :||      ...|.|.::.| ..|||...
Zfish    57 SYRLHIKFKESVVNNCSCE-----------------VSV------PLQLIECVECR-DMFQLHIT 97

  Fly  1030 AFDPEV------TPEQIESFRKILSKARHP---FDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLK 1085
            ..|.::      |.||.:.:.|.|:.|..|   .:|...|||.::      ...|.|.||.
Zfish    98 CKDCKIVRCQFSTFEQCQEWLKRLTAAVRPPSRIEELFSFAFHAW------CVDLYTGEKE---- 152

  Fly  1086 GFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLT 1150
                                                           :.||.....::.|.|.
Zfish   153 -----------------------------------------------QHGDLCRPGDHVMSRF-- 168

  Fly  1151 TKDVERMRERSYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRC 1215
            ..:||||            |||  :|..:|:|..|..|..|.|||.:::.|...:|..:.::...
Zfish   169 HNEVERM------------GFD--TQNAWRVSEINNKYKLCSSYPQLLLVPAWITDKELENVAAF 219

  Fly  1216 FKGQRIPLPTWRH-ANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINT 1279
            ...:|||...:|| :.||::.|.|||         :.:.....||  |..|          |:.:
Zfish   220 RSWKRIPAVVYRHQSTGAVIARCGQP---------EVSWWGWRNA--DDEH----------LVQS 263

  Fly  1280 MPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKG 1344
            :.:          ...:..||..|.|:.        .|||::.|..|:||.:..|     .....
Zfish   264 IAR----------ACAVDSSSCKGVSNG--------SLSREYTNGADLSDVDFES-----SMTNS 305

  Fly  1345 NPKNSLAHPFRKM-----RLYALGEKSQAKSNMNVDFCADFIP------VDYPDIRQSRPAFKKL 1398
            :...:||...||:     |.||....::||.....  |.::.|      :...:|...|.:|:.|
Zfish   306 SEVETLAIQPRKLLILDARSYAAAVANRAKGGGCE--CPEYYPNCEVVFMGMANIHSIRKSFQSL 368

  Fly  1399 IRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQ 1463
            ...|     |...|..::...:|.:.|||.:|.|::.|..|.:.:|.....|::...||.|.|.|
Zfish   369 RFLC-----TQMPDPANWLSALESTKWLQHLSLLLKASLLVSNAVDRDHRPVLVHCSDGWDRTPQ 428

  Fly  1464 LSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQL 1528
            :.::|:|.||||||:::||:||||.|||.|||:||.|.....:..:.| ...|.|||:||.||||
Zfish   429 IVALAKLLLDPYYRTIEGFQVLVETEWLDFGHKFADRCGHGENAEDLN-ERCPVFLQWLDCVHQL 492

  Fly  1529 QRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMA 1593
            |||||.:||||:.:|..|..|:.||.|.|||.:...||.|..|
Zfish   493 QRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNSGKEREDRRI---------------------- 535

  Fly  1594 TNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVA 1658
               .:..|||:.|...:.|:                        |.|.|||......|.|..:|.
Zfish   536 ---QERTCSVWSLLRAANRS------------------------FGNMLYSSHSETVLHPVCHVR 573

  Fly  1659 ALDLW-CYY------TNEELAQGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNMEKCNPSAYV 1716
            .|.|| ..|      |.......|||.......:|     :..|:|.. |..:||:    |||
Zfish   574 NLMLWTAVYLPSSSPTTPSDDSCAPYPAPGANPED-----QPLGRRPK-TRSFDNL----PSA-- 626

  Fly  1717 C-----LLSEVKQAETERGHLPQKWLQVWNSLEV 1745
            |     |.|..:.::..   |.:||.....|||:
Zfish   627 CEVGNPLTSNRRSSDPS---LNEKWQDHRRSLEL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	25/122 (20%)
		Myotub-related	1161..1565	CDD:284109	127/415 (31%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtmr3	XP_021333893.1	PH-like	24..143	CDD:327399	34/165 (21%)
		Myotub-related	167..531	CDD:310891	133/431 (31%)
		FYVE_MTMR3	1094..1163	CDD:277271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840