DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtm

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	179/776 - (23%)
Similarity:	277/776 - (35%)	Gaps:	289/776 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 DGREDETQ-------CLI--PAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKIS 1002
            :|.||:.|       |..  |..|||.:||||:.|:..|....  |..:|...|:..:.:.:||.
  Fly    51 EGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQ--EPPVVVDVPLGVIARVEKIG 113

  Fly  1003 VLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGT 1067
                         |...|..:                                        |||
  Fly   114 -------------GATSRGEN----------------------------------------SYG- 124

  Fly  1068 MLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQT-KRKLVSDYDYGSADAQETQSIDDE 1131
                            ::.|.|.  :|..:   |..|||. .|:.|.:
  Fly   125 ----------------IEIFCKD--MRNLR---FAHKQQNHSRRTVFE----------------- 151

  Fly  1132 LEDGDEFETQNNAMP-----RLLTTKD--VERMRERSYVQDW---------KRLGFDAESQRGFR 1180
                   :.|.||.|     ||.....  ...:........|         :|||...:.   :|
  Fly   152 -------KLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDM---WR 206

  Fly  1181 ISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQPNSKS 1244
            .:..|.|||.|.||||:...|...||..:..:.:.....|:|:.:|.: ...|.:.|..||
  Fly   207 ATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQP---- 267

  Fly  1245 VIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDD 1309
                |...:|...:          .|:.:|:.|                       :..::.||
  Fly   268 ----LVGVSGKRNS----------DDEAYLSFI-----------------------MEANAQSD- 294

  Fly  1310 RQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLYALGEKSQAKSNMNV 1374
              .||...:|...|.:    .||:..||.                         |...|..|:.:
  Fly   295 --KLTIMDARPSANAI----ANKAKGGGY-------------------------ESEDAYKNVEI 328

  Fly  1375 DFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAV 1439
            :|      :|..:|...|.:.:|:..||.|:     .|...:...::.:.||:.|..:  |:|||
  Fly   329 NF------LDIHNIHVMRESLRKVKEACFPT-----TDDSKWQTAIDNTLWLKHIRCI--LAGAV 380

  Fly  1440 --VDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHR-- 1500
              ||.::...:||::...||.|.||||::::.|.|||:||::.||.||:|||||:|||:|..|
  Fly   381 RIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIG 445

  Fly  1501 -SNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCEL 1564
             .:.|.|.|:.    :|.||||:|.|.|:.:||..|||||:.:|..:..|..||||.|||.:.|.
  Fly   446 HGDNKHSDADR----SPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEA 506

  Fly  1565 ERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIE 1629
            ||      ..||      .||                          :..:....|..|:..|:
  Fly   507 ER------VAED------LKH--------------------------KTTSLWTHINSSLDQYL- 532

  Fly  1630 RQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLW-----------------CYYTNEELAQ 1673
                 .|:|.:|.:..:  :.|||..:|.::.||                 |..|.|.|::
  Fly   533 -----NPLFPSFTHGAE--LVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTRELLSK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	22/108 (20%)
		Myotub-related	1161..1565	CDD:284109	117/418 (28%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	34/202 (17%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	119/423 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940